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Native Human Complement factor H

Cat.No.: CFH-23H
Product Overview: Native Human Complement factor H was purified from normal human serum.
Description: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source: Human serum
Species: Human
Bio-activity: >90% versus normal human serum standard
Molecular Mass: 155,000 Da (single chain)
Purity: >95% by SDS-PAGE
Storage: -70°C or below. Avoid freeze/thaw.
Concentration: 1.0 mg/mL
Storage Buffer: 10 mM sodium phosphate, 145 mM NaCl, pH 7.3
Preservative: None, 0.22 µm filtered
Gene Name: CFH complement factor H [ Homo sapiens (human) ]
Official Symbol: CFH
Synonyms: complement factor H; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; CFH; complement factor H; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1
Gene ID: 3075
mRNA Refseq: NM_000186
Protein Refseq: NP_000177
MIM: 134370
UniProt ID: P08603
Chromosome Location: 1q32
Pathway: Complement and coagulation cascades; Immune System; Staphylococcus aureus infection
Function: heparan sulfate proteoglycan binding; heparin binding; protein binding

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