"IRAK1" Related Products


Recombinant Human IRAK1, His-tagged

Cat. No. : IRAK1-1542H
Product Overview : Recombinant Human IRAK1 was expressed inE.Coliusing an N-terminal His tag. MW= 15kDa.
Description : Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response.
Source : E.Coli.
Sequence : 618-712.
Purity : ~95%.
Specific Activity : n/aH.
Applications : E, WB, MS.
Buffer : 100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% glycerol.
Storage : Store at -70?C. As with any protein, exposing IRAK1 recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
SDS-PAGE : SDS-PAGE analysis of recombinant IRAK fragment on Coomassie Blue-stained 12% SDS-PAGE gel.
Gene Name : IRAK1 interleukin-1 receptor-associated kinase 1 [ Homo sapiens ]
Synonyms : IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; EC; interleukin-1 receptor-associated kinase 1; Pelle homolog
Gene ID : 3654
mRNA Refseq : NM_001025242
Protein Refseq : NP_001020413
MIM : 300283
UniProt ID : P51617
Chromosome Location : Xq28
Pathway : Apoptosis; Neurotrophin signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system; Signalling by NGF
Function : ATP binding; NF-kappaB-inducing kinase activity; interleukin-1 receptor binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; transcription activator activity; transferase activity

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