Native Human SRC

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Native Human SRC

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Cat.No. : SRC-29697TH
Product Overview : Fusion protein, corresponding to amino acids 84-145 of Human Src and proprietary protein, approximately 33kDa.
Description : This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source : E. coli
Form : Lyophilised:Reconstitute within H2O bid.
Purity : Immunogen affinity purified
Storage buffer : Preservative: NoneConstituents: 50mM Potassium phosphate, 20mM Sodium chloride, pH 6.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.
Gene Name : SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
Official Symbol : SRC
Synonyms : SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src;
Gene ID : 6714
mRNA Refseq : NM_005417
Protein Refseq : NP_005408
MIM : 190090
Uniprot ID : P12931
Chromosome Location : 20q12-q13
Pathway : ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem;
Function : ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; heme binding;

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