Native Human Alpha-2-macroglobulin Protein

Cat.No. : A2M-01H
Product Overview : Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, purified from Human plasma.
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Description : The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Source : Human Plasma
Species : Human
Protein length : Full Length
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O.
Molecular Mass : 725 kDa
Purity : Greater than 96.0 %
Note : For Research Use Only. Not for use in diagnostic procedures.
Storage : Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8 centigrade. Do not freeze!
Storage Buffer : Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0.
Gene Name : A2M alpha-2-macroglobulin [ Homo sapiens (human) ]
Official Symbol : A2M
Synonyms : A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2MD; S863-7; DKFZp779B086;
Gene ID : 2
mRNA Refseq : NM_000014
Protein Refseq : NP_000005
MIM : 103950
UniProt ID : P01023

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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04/19/2022

    It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.

    05/23/2020

      Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.

      03/09/2020

        The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.

        Q&As (6)

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        What role does A2M protein play in the immune system? 12/18/2022

        It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

        What is the relationship between A2M protein and lung disease? 09/29/2022

        Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

        In which organs or tissues are A2M proteins expressed high? 08/12/2021

        The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

        How does A2M protein remove harmful proteins from the body? 10/14/2020

        Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

        Can A2M protein be used as a potential therapeutic target for cardiovascular disease? 06/13/2020

        A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

        In which neurological diseases are A2M proteins studied? 10/30/2019

        A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.

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