Native Human Alpha-2-macroglobulin Protein
Cat.No. : | A2M-01H |
Product Overview : | Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, purified from Human plasma. |
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Description : | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
Source : | Human Plasma |
Species : | Human |
Protein length : | Full Length |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O. |
Molecular Mass : | 725 kDa |
Purity : | Greater than 96.0 % |
Note : | For Research Use Only. Not for use in diagnostic procedures. |
Storage : | Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8 centigrade. Do not freeze! |
Storage Buffer : | Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0. |
Gene Name : | A2M alpha-2-macroglobulin [ Homo sapiens (human) ] |
Official Symbol : | A2M |
Synonyms : | A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2MD; S863-7; DKFZp779B086; |
Gene ID : | 2 |
mRNA Refseq : | NM_000014 |
Protein Refseq : | NP_000005 |
MIM : | 103950 |
UniProt ID : | P01023 |
Products Types
◆ Native Protein | ||
A2m-8030M | Native Mouse A2m | +Inquiry |
A2m-367M | Native Mouse Alpha-2-Macroglobulin | +Inquiry |
A2m-695R | Native Rat Alpha-2-Macroglobulin | +Inquiry |
◆ Lysates | ||
A2M-593HCL | Recombinant Human A2M cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIt can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.
Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.
The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.
Q&As (6)
Ask a questionIt play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.
Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.
The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.
Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.
A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.
A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.
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