Recombinant Full Length Human CD40 Protein, N-GST-tagged

• Cat.No.: CD40-13HFL
• Product Overview: Recombinant Full Length Human CD40 Protein, fused to GST-tag at N-terminus, was expressed in Wheat Germ (in vitro).

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Source: Wheat Germ
• Species: Human
• Tag: N-GST
• Protein length: 1-277 aa
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 56.1 kDa
• AA Sequence: MVRLPLQCVLWGCLLTAVHPEPPTA CREKQYLINSQCCSLCQPGQKLVSD CTEFTETECLPCGESEFLDTWNRET HCHQHKYCDPNLGLRVQQKGTSETD TICTCEEGWHCTSEACESCVLHRSC SPGFGVKQIATGVSDTICEPCPVGF FSNVSSAFEKCHPWTSCETKDLVVQ QAGTNKTDVVCGPQDRLRALVVIPI IFGILFAILLVLVFIKKVAKKPTNK APHPKQEPQEINFPDDLPGSNTAAP VQETLHGCQPVTQEDGKESRISVQE RQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CD40 CD40 molecule [ Homo sapiens (human) ]
• Official Symbol: CD40
• Synonyms: CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5
• Gene ID: 958
• mRNA Refseq: NM_001250.6
• Protein Refseq: NP_001241.1
• MIM: 109535
• UniProt ID: P25942