Recombinant Human KLRC1&KLRD1 Heterodimer Protein, His/FLAG-tagged

• Cat.No.: KLRC1&KLRD1-160H
• Product Overview: Recombinant Human NKG2A & CD94 Heterodimer Protein is produced by human 293 cells. The target gene encoding Arg100-Leu233 & Ser34-Ile179 is expressed with 8His & Flag tag at the Nterminus.

Specification

• Description: NKG2-A contains C-type lectin domain and belongs to the killer cell lectin-like receptor (KLR) family. KLR family is a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94, also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of NK cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I Human Leukocyte Antigen (HLA)-E molecules by NK cells and some cytotoxic T-cells. CD94 can form disulfide-bonded heterodimer with NKG2A on the surface of NK cells. The CD94/NKG2A complex interacts with HLA-E on target cells and inhibit the cytotoxic activity of NK cells to prevent cell lysis.
• Source: HEK293
• Species: Human
• Tag: His/FLAG
• Form: Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4.
• Molecular Mass: Predicted Molecular Weight: 18.7KDa&20.1KDa
• AA Sequence: R100-L233; S34-I179
• Endotoxin: Less than 0.1 EU/ug.
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Quality Statement: Purity: >95% by SDS-PAGE gel and coomassie blue staining.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: KLRC1 killer cell lectin like receptor C1 [ Homo sapiens (human) ]&KLRD1 killer cell lectin like receptor D1 [ Homo sapiens (human) ]
• Official Symbol: KLRC1&KLRD1
• Synonyms: KLRC1&CD94 Heterodimer; CD159A&KLRD1 Heterodimer
• Gene ID: 3821&3824
• mRNA Refseq: NM_002259.5&NM_001114396.3
• Protein Refseq: NP_002250.2&NP_001107868.2
• MIM: 161555&602894
• UniProt ID: P26715&Q13241