| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
Flag&His |
| Protein Length : |
100-233;34-179 a.a. |
| Description : |
NKG2-A contains C-type lectin domain and belongs to the killer cell lectin-like receptor (KLR) family. KLR family is a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94, also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of NK cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I Human Leukocyte Antigen (HLA)-E molecules by NK cells and some cytotoxic T-cells. CD94 can form disulfide-bonded heterodimer with NKG2A on the surface of NK cells. The CD94/NKG2A complex interacts with HLA-E on target cells and inhibit the cytotoxic activity of NK cells to prevent cell lysis. |
| Form : |
Lyophilized frum a 0.2 um filtered solution of PBS, pH7.4. |
| Molecular Mass : |
Predicted Molecular Weight: 18.7KDa&20.1KDa |
| AA Sequence : |
R100-L233; S34-I179 |
| Endotoxin : |
Less than 0.1 EU/ug. |
| Purity : |
>95% |
| Storage : |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Reconstitution : |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Quality Statement : |
Purity: >95% by SDS-PAGE gel and coomassie blue staining. |
| Shipping : |
The product is shipped at ambient temperature. |
