Recombinant Human MERTK, Gly & Pro tagged
Cat.No. : | MERTK-472H |
Product Overview : | Recombinant Human MERTK (Q12866) (Glu578-Tyr872), fused with two additional amino acids (Gly & Pro) at the N-terminus, was produced in Baculovirus-Insect cells. |
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Source : | Baculovirus-Insect cells |
Species : | Human |
Tag : | Gly & Pro |
Predicted N Terminal : | Gly |
Form : | Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.3mM DTT, 10% glycerol, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : | The secreted recombinant human MERTK consists of 297 amino acids and predicts a molecular mass of 34.1 KDa. The apparent molecular mass of the protein is approximately 29 KDa in SDS-PAGE under reducing conditions due to glycosylation. |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >85 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Protein length : | Glu578-Tyr872 |
Gene Name : | MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ] |
Official Symbol : | MERTK |
Gene ID : | 10461 |
mRNA Refseq : | NM_006343 |
Protein Refseq : | NP_006334 |
MIM : | 604705 |
UniProt ID : | Q12866 |
Chromosome Location : | 2q14.1 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewFast shipping and excellent service. This product is a lab essential.
Highly recommend for quality and prompt delivery.
Exceptional product, outstanding customer service!
Q&As (5)
Ask a questionMERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.
The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.
MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.
MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.
Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.
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