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Active Recombinant Mouse Cfh Protein, His-tagged

Cat.No. : Cfh-626M
Product Overview : Recombinant Mouse Cfh (Accession # NP_034018) Ser875-Val1252, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
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  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Ser875
Form : Lyophilized from a 0.2 µm filtered solution in Tris and NaCl.
Bio-activity : Measured by the ability of the immobilized protein to induce the adhesion of human neutrophils. DiScipio, R.G. et al. (1998) J. Immunol. 160:4057.The ED50 for this effect is typically 3 - 18 µg/mL in the presence of 50 ng/mL of rhTNF-alpha.
Molecular Mass : Recombinant Mouse Cfh, His-tagged has a calculated MW of 43.2 kDa. In SDS-PAGE migrates as 64 kDa, reducing conditions.
Protein length : Ser875-Val1252
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 10 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : Cfh complement component factor h [ Mus musculus ]
Official Symbol : Cfh
Synonyms : CFH; complement component factor h; complement factor H; protein beta-1-H; complement factor H related protein 3A4/5G4; NOM; Sas1; Mud-1; Sas-1;
Gene ID : 12628
mRNA Refseq : NM_009888
Protein Refseq : NP_034018
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of CFH mutations on the risk of developing atypical hemolytic uremic syndrome (aHUS)? 02/13/2022

Mutations in CFH increase the risk of aHUS, affecting complement regulation and leading to kidney damage.

How does CFH (Complement Factor H) regulate the complement system and prevent overactivation? 06/07/2021

CFH controls the complement system, preventing its overactivation and protecting against immune damage.

How does CFH influence the immune response to bacterial infections? 01/07/2020

CFH modulates the immune response to bacterial infections, balancing defense mechanisms.

How does CFH deficiency contribute to the development of age-related macular degeneration (AMD)? 09/09/2019

CFH deficiency is linked to AMD, due to impaired regulation of the complement pathway in the retina.

What role does CFH play in protecting host cells from complement-mediated damage? 04/03/2019

CFH shields host cells from complement-mediated injury, maintaining tissue integrity.

What are the mechanisms by which CFH modulates inflammation and immune homeostasis? 01/23/2019

CFH regulates inflammation and maintains immune balance, crucial for preventing excessive immune responses.

How do alterations in CFH expression or function affect renal function and the development of kidney diseases? 01/18/2018

Changes in CFH function can impact kidney health, potentially leading to renal diseases due to altered complement activity.

Customer Reviews (3)

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Reviews
11/16/2020

    Exceptional protein expression optimization support, highly appreciated assistance.

    07/31/2020

      Precise protein quantification, ensures data accuracy in our research.

      03/10/2018

        Timely antibody validation, an invaluable asset for our laboratory.

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