Recombinant Mouse Csf3 protein
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|Product Overview :||Recombinant Mouse Csf3 protein (Met1-Ser390) was fused to His-tag at the C-terminus and expressed in HEK293 cells.|
|Description :||Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also revealed that G-CSF activates multiple signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been demonstrated to improve cardiac function and perfusion in myocardial infarction. And it was initially evaluated as a stem cell mobilizer and erythropoietin as a cytoprotective agent. G-CSF prevents left ventricular remodeling after myocardial infarction by decreasing cardiomyocyte death and by increasing the number of blood vessels, suggesting the importance of direct actions of G-CSF on the myocardium rather than through mobilization and differentiation of stem cells. Accordingly, recombinant human (rh)G-CSF has been extensively used in clinical haematology and oncology to enable bone marrow transplantation or to treat chemotherapy-associated neutropenia. In preclinical study, G-CSF improved cardiac function and perfusion by angiomyogenesis and protection of cardiomyocytes in myocardial infarction.|
|Predicted N Terminal :||Val31|
Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
|Molecular Mass :||The recombinant mouse CSF3 consists of 178 amino acids and predicts a molecular mass of 19 kDa.|
|Protein length :||178|
|Endotoxin :||<1.0 EU per μg of the protein as determined by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE. >95% as determined by SEC-HPLC.|
|Stability :||Samples are stable for up to twelve months from date of receipt at -20 centigrade to -80 centigrade.|
|Storage :||Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
|SDS-PAGE of Csf3-275M :||
98.9% as determined by SDS-PAGE.
|SEC-HPLC of Csf3-275M :||
99.7% as determined by SEC-HPLC.
|Gene Name :||Csf3|
|Official Symbol :||Csf3|
|Synonyms :||Csfg; G-CSF; MGI-IG|
|Gene ID :||12985|
|mRNA Refseq :||NM_009971.1|
|Protein Refseq :||NP_034101.1|
|UniProt ID :||P09920|
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