Recombinant Rat IL25 Protein
|Product Overview :||Rat IL25 recombinant protein expressed in Escherichia coli.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq|
|Source :||E. coli|
|Bio-activity :||The activity is determined by the dose-dependent induction of human IL-8 production from human PBMCs. The expected ED50 for this effect is 25-37.5 ng/mL.|
|Molecular Mass :||35.5 kDa|
|AA Sequence :||MCSHLPRCCPSKQQEFPEEWLKWNP APVSPPEPLRHTHHPESCRASKDGP LNSRAISPWSYELDRDLNRVPQDLY HARCLCPHCVSLQTGSHMDPMGNSV PLYHNQTVFYRRPCHGEQGAHGRYC LERRLYRVSLACVCVRPRMMA|
|Endotoxin :||< 0.1 EU/μg|
|Applications :||Functional Study
|Storage :||Store at -20 centigrade on dry atmosphere. After reconstitution with sterilized 20 mM HCl, store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||No additive|
|Gene Name :||Il25 interleukin 25 [ Rattus norvegicus ]|
|Official Symbol :||IL25|
|Synonyms :||IL25; interleukin 25; interleukin-25; RGD1561632;|
|Gene ID :||501996|
|mRNA Refseq :||NM_001192007|
|Protein Refseq :||NP_001178936|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.
There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.
In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.
IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.
Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.
Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.
Customer Reviews (3)Write a review
Efficacy of the protein can be evaluated by observing its pharmacokinetics, pharmacodynamics and toxicity in mice or rats. -
Animal models were used to evaluate the efficacy and side effects of the remade proteins. -
Storage is stable, and the environmental requirements are not harsh. -
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