igf1r
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  • Official Full Name
  • insulin-like growth factor 1 receptor
  • Background
  • This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
  • Synonyms
  • IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
Cat.#:IGF1R-1391HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IGF1R Protein, DDK-tagged
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Cat.#:IGF1R-1392HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1R Protein, MYC/DDK-tagged
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Cat.#:IGF1R-22MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IGF1R Protein, His-tagged
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Cat.#:IGF1R-391HTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus IGF1R protein, His-tagged
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Cat.#:IGF1R-392MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IGF1R protein, His-tagged
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Cat.#:IGF1R-393RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IGF1R protein, His-tagged
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Cat.#:IGF1R-134HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IGF1R protein, DDK-tagged
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Cat.#:IGF1R-1631HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1 Receptor
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Cat.#:IGF1R-1769HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1R protein, His & T7-tagged
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Cat.#:IGF1R-180HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1R, His-tagged
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Cat.#:IGF1R-214HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1R protein, DDK/His-tagged
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Cat.#:IGF1R-240HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IGF1R
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Cat.#:IGF1R-2654HTag:His|GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 1 Receptor, GST-His
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Cat.#:IGF1R-29114THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1R
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Cat.#:IGF1R-29115THTag:His
Source (Host):Species:Human
Product nameRecombinant Human IGF1R, His-tagged
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Cat.#:IGF1R-29118THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IGF1R
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Cat.#:IGF1R-29HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged
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Cat.#:IGF1R-3148HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1R, His tagged
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Cat.#:IGF1R-330HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged, Active
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Cat.#:IGF1R-50HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IGF1R, His & GST tagged
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Cat.#:IGF1R-51HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IGF1R protein, Flag-tagged, Biotinylated
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Cat.#:IGF1R-3004RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IGF1R Protein
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Cat.#:Igf1r-30RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igf1r protein, His-tagged
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Cat.#:IGF1R-2216RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IGF1R Protein, His-tagged
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Cat.#:IGF1R-6589CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF1R
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Cat.#:IGF1R-663HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1 Receptor
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Cat.#:IGF1R-2928HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1R cell lysate
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Cat.#:Kit-1600Tag:N/A
Source (Host):Species:
Product nameIGF1R Functional Assay Kit
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Cat.#:Kit-1601Tag:N/A
Source (Host):Species:
Product nameHEK 293 IGF1R Bioassay Kit
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Involved Pathway

IGF1R involved in several pathways and played different roles in them. We selected most pathways IGF1R participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FGF16; PLA2G12B; GNG8; PRKACG; HTR7; PIK3R5; GAB2; FGF20; RAC2; PDGFA
Rap signaling pathway
ARAP3; RALB; FGF1; FGFR3; FGF13; GNAI2; PIK3CA; TLN1; PLCE1; ID1
HIF- signaling pathway
MTOR; HK1; MKNK2; CAMK2B; PRKCG; MAP2K1; PIK3R3; PGK1; PDHA1; CAMK2A
FoxO signaling pathway
PIK3R3; CDKN2D; RAG2; MAPK12; CDKN1BA; GADD45AB; TGFBR2; NLK; AGAP2; PRMT1
Oocyte meiosis
SPDYB; PLCZ1; ANAPC11; SPDYA; SGOL1; CALM1B; PPP2R5A; PPP2R5EB; CALM2B; PRKACAB
Endocytosis
NEDD4L; ADRB3A; AMPH; EHD1; HLA-G; VPS4B; RHOAB; SNX1B; ARPC5B; CHMP4B
PIK-Akt signaling pathway
MDM2; PHLPP2; FGF1; PHLPP1; GNG5; GNG7; LAMC2; FGF18; IL7; ITGB6
AMPK signaling pathway
CFTR; ADRa1A; ADIPOR2; CPT1C; PIK3CD; ADIPOQ; INS; HMGCR; PFKM; RAB8A
Focal adhesion
PIK3CB; THBS4A; PPP1R12B; COL5A2; MAPK8; EGFRA; PXNA; PRKCG; KDR; ERBB2
Adherens junction
BAIAP2; YES1; WASF3; WASF3B; CTNNA1; PVRL4; CREBBP; CDC42; RAC3; TGFBR1B
Signaling pathways regulating pluripotency of stem cells
HAND1; ZIC3; WNT5B; PIK3CG; Fzd4; SMAD4; STAT3; WNT8B; FGFR3; WNT10B
Long-term depression
PRKCG; GUCY1A3; PLA2G4F; KRAS; RAF1; PRKCA; ITPR3; GNAZ; NRAS; HRAS
Ovarian steroidogenesis
Adcy4; CYP2J6; HSD17B2; INS; INSR; LHCGR; HSD17B1; PLA2G4D; LDLR; HSD3B4
Progesterone-mediated oocyte maturation
MOS; INS2; PRKACA; CPEB1A; MAD2L2; RPS6KA1; MAPK12B; PLK1; GNAI3; PRKACAB
Pathways in cancer
LAMB1; BMP2; ARHGEF1; Flt3l; FZD5; PLCB4; ARHGEF12; FGF16; ARNT; FGFR3
Transcriptional misregulation in cancer
HIST1H3A; PAX3; ETV4; HMGA2; REL; RXRA; NUPR1; RUNX2; HIST3H3; ZBTB16
Proteoglycans in cancer
HRAS; LUM; PLCG2; CAMK2A; CD44; SDC2; GPC3; PLAUR; KRAS; SDC1
Glioma
PIK3CB; NRAS; CAMK2G; MAP2K1; PLCG2; RAF1; MAPK1; CAMK2D; BRAF; CAMK2A
Prostate cancer
PDGFB; PIK3CG; HSP90B1; PIK3R3; CREB3L3; CASP9; MAPK1; SMARCD1; GSK3B; BCL2
Melanoma
FGF12; FGF21; RB1; FGF13; RAF1; FGF11; FGF22; FGF4; PIK3CD; Fgf15

Protein Function

IGF1R has several biochemical functions, for example, ATP binding, G-protein alpha-subunit binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1R itself. We selected most functions IGF1R had, and list some proteins which have the same functions with IGF1R. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIP4K2A; AK3; PANK1; ACTA2; TTLL3; MAPK7; TTL; UBE2N; SLK; CDK12
Function G-protein alpha-subunit binding
Related Protein RGS19; LPAR1; RGS14; PPP5C; RIC8B; HTR2B; ARHGEF11; RGS4; CRHR1; AGTR1A
Function identical protein binding
Related Protein MLL1; SDCBP; HACL1; PLIN5; SUN2; PLDN; AGER; RBM10; INS; SAFB2
Function insulin binding
Related Protein INSR; HSPD1; PIK3R1; IGF1R; C2CD2L; IDE
Function insulin receptor binding
Related Protein GRB10; DOK7; SLC2A2; IGF1R; PIK3R1; IRS1; IGF2; SNX2; SHC1; FRS2B
Function insulin receptor substrate binding
Related Protein INSRB; PRKCZ; INSRA; JAK2; PIK3R1; IGF1R; INSRR; PTPN11; INSR; IGF1RB
Function insulin-like growth factor I binding
Related Protein IGFBP5A; IGFBP2A; IGF1R; IGFBP1A; IGFBP3; IGFBP1B; IGFBP6; IGFBP2; IGFBP4; IGFBP5
Function insulin-like growth factor binding
Related Protein WISP1; NOV; IGFBP7; IGFBP6B; IGFBP6A; IGFBP1B; WISP1A; IGF2R; Igfbpl1; HTRA4
Function insulin-like growth factor-activated receptor activity
Related Protein IGF2R; IGF1R
Function phosphatidylinositol 3-kinase binding
Related Protein IRS2; ATP1A1; INSRB; INSR; CALM2; CALM1; JAK2; FLT3; FYN; PIK3R1
Function protein binding
Related Protein RBBP7; PRPF4B; BARD1; PCSK2; DRD1A; NXF2; ADAMTSL5; SPARC; CLIC2; FHL1
Function protein tyrosine kinase activity
Related Protein EPHA7; KITA; SYK; EK1; ERBB3A; WEE1; DYRK3; DYRK2; MAP2K1; NEK1

Interacting Protein

IGF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1R.
YWHAB; PIK3R1; PTPN1; ARHGEF12

IGF1R Related Articles

Huang, CT; Chang, MC; et al. Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. CANCER LETTERS 359:117-126(2015).
Wang, YX; Zhu, LY; et al. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17 beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1382-E1391(2015).

IGF1R Related Gene Family

Cytokines