IGF1R

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IGF1R

Official Full Name insulin-like growth factor 1 receptor
Background This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Synonyms IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
    • Species :
    • Chicken
    • Cynomolgus
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • NSO
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • His
    • Flag
    • GST
    • T7
    • His-Avi
    • Myc/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Igf1r-1223M Recombinant Mouse Igf1r Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human IGF1R-169H Recombinant Human IGF1R protein, His-Avi-tagged HEK293 His-Avi
    Cynomolgus IGF1R-391H Recombinant Cynomolgus IGF1R protein, His-tagged HEK293 His
    Mouse IGF1R-392M Recombinant Mouse IGF1R protein, His-tagged HEK293 His
    Rat IGF1R-393R Recombinant Rat IGF1R protein, His-tagged HEK293 His
    Human IGF1R-595H Recombinant Human IGF1R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CAB11558MH Mouse Anti-Human Insulin-like Growth Factor 1 Receptor Monoclonal Antibody Mouse N/A
    Human IGF1R-134H Recombinant Human IGF1R protein, DDK-tagged Insect Cell DDK
    Human IGF1R-1391H Recombinant Human IGF1R Protein, DDK-tagged Insect Cell DDK
    Human IGF1R-1392H Recombinant Human IGF1R Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IGF1R-1631H Recombinant Human Insulin-Like Growth Factor 1 Receptor NSO N/A
    Human IGF1R-1769H Recombinant Human IGF1R protein, His & T7-tagged E.coli His/T7
    Human IGF1R-180H Recombinant Human IGF1R protein, His-tagged HEK293 His
    Human IGF1R-214H Recombinant Human IGF1R protein, DDK/His-tagged HEK293 DDK/His
    Human IGF1R-240H Recombinant Human IGF1R Mammalian Cell His
    Human IGF1R-2654H Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His S.frugiperda His/GST
    Human IGF1R-29114TH Recombinant Human IGF1R E.coli N/A
    Human IGF1R-29115TH Recombinant Human IGF1R, His-tagged His
    Human IGF1R-29118TH Recombinant Human IGF1R N/A
    Human IGF1R-2928HCL Recombinant Human IGF1R cell lysate Human Cell N/A
    Human IGF1R-29H Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged Human Cell His
    Human IGF1R-3148H Recombinant Human IGF1R, His tagged Human Cell His
    Human IGF1R-330H Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged, Active Sf9 Insect Cell GST
    Human IGF1R-50H Recombinant Human IGF1R, His & GST tagged Insect Cell His/GST
    Human IGF1R-51H Recombinant Human IGF1R protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human IGF1R-663H Recombinant Human Insulin-Like Growth Factor 1 Receptor Human N/A
    Mouse IGF1R-22M Recombinant Mouse IGF1R Protein, His-tagged CHO His
    Rat IGF1R-3004R Recombinant Rat IGF1R Protein Mammalian Cell His
    Rat Igf1r-30R Recombinant Rat Igf1r protein, His-tagged E.coli His
    Rhesus Macaque IGF1R-2216R Recombinant Rhesus monkey IGF1R Protein, His-tagged Mammalian Cell His
    Chicken IGF1R-6589C Recombinant Chicken IGF1R Mammalian Cell His
    Kit-1600 IGF1R Functional Assay Kit N/A
    Kit-1601 HEK 293 IGF1R Bioassay Kit N/A

    IGF1R involved in several pathways and played different roles in them. We selected most pathways IGF1R participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PDGFD; AKT1; RIN1; RASGRP3; STK4; FGFR3; PLA2G2F; RASAL3; GNB1; GNG12
    Rap signaling pathway VASP; GRIN1; VEGFC; PLCG1; PRKD3; BCAR1; SIPA1L2; MAP2K6; PLCB1; RAP1A
    HIF- signaling pathway IFNGR2; RPS6; NFKB1; GAPDH; INS1; MAP2K2; PIK3R3; HK1; Trf; PIK3R1
    FoxO signaling pathway PIK3R5; PRKAG3; NLK1; USP7; NLK2; ARAF; FOXG1; G6PCA.1; GADD45BA; CDKN2D
    Oocyte meiosis CALM2B; RPS6KA1; ESPL1; REC8; CPEB3; SMC3; MAPK12; CPEB2; CPEB4; IGF1
    Endocytosis F2R; PARD6GA; RAB7; DNAJC6; SPG21; IL2RGA; RLN1; VPS35; CCR5; DNM2
    PIK-Akt signaling pathway FN1; PPP2R5B; GYS1; VEGFA; CREB3L3; IL7R; IGF1R; PHLPP2; PDGFD; PRKCA
    AMPK signaling pathway AKT1S1; PIK3R1; PPP2R5D; AKT1; FBP2; ACACA; PPP2CA; IGF1; CPT1A; IRS2
    Focal adhesion COL1A1B; RAF1; COL4A2; ITGB5; ITGA11A; BAD; Itga10&Itgb1; PTK2; STYK1; ITGA9
    Adherens junction MET; WASF3; PTPRF; FARP2; SMAD3A; CTNNB1; LEF1; PTPRFB; ACTB1; SNAI2
    Signaling pathways regulating pluripotency of stem cells FGFR1; REST; ZIC3; INHBC; PIK3R3; PIK3CD; WNT11; INHBA; KLF4; MAPK13
    Long-term depression HRAS; GNAI1; IGF1R; PRKCA; GUCY1A3; CRH; PRKG2; GRIA1; GNA13; GNAO1
    Ovarian steroidogenesis STAR; FSHR; LDLR; FSHB; HSD3B1; INS; IGF1; IGF1R; HSD3B6; PLA2G4F
    Progesterone-mediated oocyte maturation CDC25C; CDC16; MAPK12A; CCNA2; PRKACAA; RAF1A; CCNB3; ANAPC2; PIK3CB; CPEB1A
    Pathways in cancer KRAS; RASSF1; DAPK1; MAPK10; TRAF4; STAT5A; FZD7; PRKCG; FASLG; MSH3
    Transcriptional misregulation in cancer MAF; JMJD1C; MAX; HIST2H3C1; PAX3; PBX3; SIX4; CD40; MPO; RUNX1T1
    Proteoglycans in cancer PIK3CB; Fzd4; PRKACB; WNT5B; WNT4; HPSE2; GPC1; TGFB2; RAC1; MSN
    Glioma PDGFRA; SHC2; PLCG1; RAF1; KRAS; PRKCB; PIK3R3; NRAS; IGF1; PIK3R2
    Prostate cancer MDM2; PIK3R3; FGFR1; FGFR2; SOS1; ERBB2; CPN1; PIK3R1; PDGFRA; INS1
    Melanoma PIK3R2; FGF21; PIK3R5; PDGFD; PIK3CG; FGF17; TP53; PDGFRB; FGF20; FGF8

    IGF1R has several biochemical functions, for example, ATP binding, G-protein alpha-subunit binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1R itself. We selected most functions IGF1R had, and list some proteins which have the same functions with IGF1R. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding FGFR4; CHD6; TOP2A; TOR1; NLK1; ATP1A3A; CLCN4-2; PTK7; DDX23; DNAJA3A
    G-protein alpha-subunit binding RIC8B; AGTR1A; F2RL1; LPAR1; LPAR3; RGS4; NUCB1; DRD1; IGF1R; OPRM1
    identical protein binding PRC1; ASMT; ATL1; CLDN23; CEP72; TRIM8; BNIP3; FBP1; CLDNG; MCPH1
    insulin binding HSPD1; IDE; PIK3R1; IGF1R; INSR; C2CD2L
    insulin receptor binding DOK3; FRS2A; DOK4; PIK3R1; SNX4; DOK6; PTPN11; LMBRD1; FRS2; SNX2
    insulin receptor substrate binding PIK3R1; IGF1RA; PIK3CB; INSRB; INSRR; IGF1R; PRKCZ; JAK2; GRB2; PTPN11
    insulin-like growth factor I binding IGFBP6; IGFBP4; IGFBP5A; IGFBP1A; IGFBP3; IGFBP6A; IGFBP5B; IGFBP2B; IGFBP2; IGFBP5
    insulin-like growth factor binding IGFBP3; KAZALD1; IGFBP2A; KAZALD2; IGFALS; WISP1B; IGFBP2B; IGFBP6B; WISP3; WISP1
    insulin-like growth factor-activated receptor activity IGF1R; IGF2R
    phosphatidylinositol 3-kinase binding IGF1RB; IGF1R; ATP1A1; CALM3; PDGFRB; TYRO3; CORO1A; FLT3; IRS1; CALM2
    protein binding PSIP1; RECQL; NOC2L; ACAT2; ATM; HM13; CFI; DHPS; SYF2; LIMD1
    protein tyrosine kinase activity MAP2K6; TNK1; LTK; PTK7; SHC1; JAK3; PDGFRB; EPHB4B; INSRA; DYRK1B

    IGF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1R.

    YWHAB; PIK3R1; PTPN1; ARHGEF12

    Huang, CT; Chang, MC; et al. Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. CANCER LETTERS 359:117-126(2015).
    Wang, YX; Zhu, LY; et al. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17 beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1382-E1391(2015).

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