il11
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  • Official Full Name
  • interleukin 11
  • Background
  • The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
  • Synonyms
  • IL11; interleukin 11; AGIF; IL-11; interleukin-11; oprelvekin; adipogenesis inhibitory factor;
Cat.#:IL11-2016HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11 Protein, Met-tagged
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Cat.#:IL11-123HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11 protein
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Cat.#:IL11-29630THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11
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Cat.#:IL11-464HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11, None tagged
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Cat.#:IL11-503HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL11 protein, His-tagged
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Cat.#:IL11-842HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11 protein, His & T7-tagged
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Cat.#:IL11-953HTag:
Source (Host):Pichia PastorisSpecies:Human
Product nameRecombinant Human IL11 Protein
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Cat.#:Il11-842MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il11 Protein
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Cat.#:Il11-843MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il11 protein, His-tagged
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Cat.#:IL11-325HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11
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Cat.#:IL11-416HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-11
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Cat.#:IL11-551HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 11
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Cat.#:Il11-586MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse interleukin 11
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Cat.#:IL11-19HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Interleukin-11
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Cat.#:IL11-218HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Interleukin 11
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Cat.#:Il11-161MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Interleukin 11
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Cat.#:IL11-5249HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL11 293 Cell Lysate
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Cat.#:IL11-101HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human IL11 Protein
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Cat.#:IL11-4326HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL11 protein
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Cat.#:IL11-124HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-11 (rDNA derived) Reference standard
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Cat.#:IL11-P012HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL11 therapeutic protein
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Involved Pathway

IL11 involved in several pathways and played different roles in them. We selected most pathways IL11 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
Ifnlr1; GDF5; ACVR2A; LEPR; CCL4L2; CSF2; CXCL5; CCR5; CXCL1; IL-15RA
Hematopoietic cell lineage
FCGR1; IL1B; CD1E; IL11; ITGA5; CD14; ITGA6; CD1d1; Flt3l; CD24
Integrated Pancreatic Cancer Pathway
TFF1; DAXX; MYT1; BRF1; RB1CC1; AGA; MST1; PPP1R13L; FKBP3; RAPGEF3
Interleukin-11 Signaling Pathway
BGLAP; IL11
Jak-STAT signaling pathway
JAK2A; AKT1; IFNE; PTPN2B; IL20RA; IFNAR1; STAT2; CRLF2; BCL2A; STAT1B
Rheumatoid arthritis
ATP6V1B1; HLA-DRB5; ATP6V1A; ATP6V1H; HLA-DOA; ATP6V0E1; ITGAL; CXCL5; Ccl12; ATP6V1E1

Protein Function

IL11 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-11 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11 itself. We selected most functions IL11 had, and list some proteins which have the same functions with IL11. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL7; IL18; IL9; INHBA; BMP2; IL36G; SLURP1; IFNG; BMP4; PRL7D1
Function growth factor activity
Related Protein BMP6; FGF1A; FGF8A; VEGFAB; TGFB2; HBEGFB; FGF10; GDNF; MIA; IL6
Function interleukin-11 receptor binding
Related Protein IL11
Function protein binding
Related Protein ZNF187; RNF2; RAB11FIP3; FRMD7; GTF3C6; SPAST; KRT33B; EIF4A3; COPS5; DKK1

Interacting Protein

IL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11.
MAGEA11; MAGEA11

IL11 Related Articles

Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
Dams-Kozlowska, H; Gryska, K; et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC BIOTECHNOLOGY 12:-(2012).

IL11 Related Gene Family

IL