kdr
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  • Official Full Name
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Background
  • Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
  • Synonyms
  • KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor;
Cat.#:KDR-1122CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus KDR Protein (Met1-Glu764), His-tagged
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Cat.#:KDR-1697HATag:FC/His
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-His-tagged, APC labeled
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Cat.#:KDR-1697HPTag:FC/His
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-His-tagged, R-PE labeled
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Cat.#:Kdr-1786MATag:FC/His
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Kdr protein, Fc-His-tagged, APC labeled
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Cat.#:Kdr-1786MPTag:FC/His
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Kdr protein, Fc-His-tagged, R-PE labeled
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Cat.#:KDR-236HATag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-236HPTag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-31716THATag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-31716THPTag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-5442HATag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-5442HPTag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-632HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR Protein, His-Avi-tagged, Biotinylated
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Cat.#:KDR-643HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-643HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-645HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-645HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR protein, Fc-tagged, R-PE labeled
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Cat.#:Kdr-7413MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kdr protein, Fc-tagged, APC labeled
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Cat.#:Kdr-7413MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kdr protein, Fc-tagged, R-PE labeled
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Cat.#:Kdr-8115MATag:mFc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kdr protein, mFc-tagged, APC labeled
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Cat.#:Kdr-8115MPTag:mFc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kdr protein, mFc-tagged, R-PE labeled
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Cat.#:KDR-83HATag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR 7 Domains protein, Fc-tagged, APC labeled
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Cat.#:KDR-83HPTag:Fc
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human KDR 7 Domains protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-8718RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat KDR protein, Fc-tagged, APC labeled
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Cat.#:KDR-8718RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat KDR protein, Fc-tagged, R-PE labeled
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Cat.#:KDR-5442HTag:Fc
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), Fc-tagged
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Cat.#:KDR-5443HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), His-tagged
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Cat.#:KDR-5446HTag:GST
Source (Host):Baculovirus infected Sf9 CellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), GST-tagged
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Cat.#:KDR-5447HTag:N/A
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase)
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Cat.#:KDR-317HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase), His-tagged
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Cat.#:KDR-1263RCLTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR HEK293 cell lysate
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Cat.#:KDR-1619RCLTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR HEK293 cell lysate
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Cat.#:KDR-1697HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human KDR, Fc-His
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Cat.#:KDR-236HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human KDR, Fc Chimera
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Cat.#:KDR-240HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR, C13&N15-labeled
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Cat.#:KDR-31715THTag:His
Source (Host):Species:Human
Product nameRecombinant Human KDR, His-tagged
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Cat.#:KDR-31716THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human KDR, Fc-tagged
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Cat.#:KDR-31717THTag:
Source (Host):Species:Human
Product nameRecombinant Human KDR
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Cat.#:KDR-340HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor, GST-tagged, Active
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Cat.#:KDR-387HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human KDR
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Cat.#:KDR-511HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human KDR protein, His-tagged
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Cat.#:KDR-58HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human KDR protein, Flag-tagged, Biotinylated
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Cat.#:KDR-61HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KDR
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Cat.#:KDR-630HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human KDR, His-tagged, Biotinylated
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Cat.#:KDR-631HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human KDR, Fc-tagged, Biotinylated
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Cat.#:KDR-643HTag:Fc
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human KDR, Fc tagged
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Cat.#:KDR-645HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR protein, Fc-tagged
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Cat.#:KDR-6865HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KDR protein, His-tagged
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Cat.#:KDR-6966HTag:His
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human KDR, His tagged
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Cat.#:KDR-6967HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR Protein, His & Avi-tagged, Biotinylated
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Cat.#:KDR-6968HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR Protein, Strep-tagged
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Cat.#:KDR-7515HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KDR, His & GST tagged
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Cat.#:KDR-83HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor, 7 Domains,Fc-tagged
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Cat.#:KDR-84HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Kinase Insert Domain Receptor, 7 Domains
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Cat.#:KDR-958HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human KDR Protein, DDK-tagged
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Cat.#:KDR-959HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human KDR Protein, DDK-tagged
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Cat.#:Kdr-1786MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Kinase Insert Domain Protein Receptor, Fc-His
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Cat.#:Kdr-6866MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Kdr protein, His-tagged
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Cat.#:Kdr-7413MTag:Fc
Source (Host):Human CellsSpecies:Mouse
Product nameRecombinant Mouse Kdr, Fc tagged
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Cat.#:Kdr-8115MTag:mFc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kdr protein, mFc-tagged
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Cat.#:KDR-947MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse KDR Protein, His-tagged
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Cat.#:KDR-1080RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat KDR Protein, His-tagged
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Cat.#:KDR-3239RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KDR Protein
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Cat.#:Kdr-6868RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Kdr protein, His & T7-tagged
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Cat.#:KDR-8718RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Kdr, Fc tagged
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Cat.#:KDR-8719RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Kdr, His-tagged
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Cat.#:KDR-8116RTag:His
Source (Host):HEK293Species:Rhesus macaque
Product nameRecombinant Rhesus macaque KDR protein, His-tagged
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Cat.#:KDR-1187CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KDR
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Cat.#:KDR-3055ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KDR
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Cat.#:KDR-6867PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig KDR protein, His & GST-tagged
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Cat.#:KDR-1421HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human KDR (Active), GST-tagged
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Cat.#:KDR-1769HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KDR cell lysate
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Cat.#:KDR-417HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KDR cell lysate
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Cat.#:KDR-1520MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse KDR cell lysate
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Cat.#:Kit-1609Tag:
Source (Host):Species:
Product nameKDR Activity Assay Kit
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Involved Pathway

Kdr involved in several pathways and played different roles in them. We selected most pathways Kdr participated on our site, such as Axon guidance, Cytokine-cytokine receptor interaction, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kdr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
RHOAE; CNTN6; NCK1; SEMA3G; TRPC4; DUSP5; EGF; LRRC4; UNC5D; UNC5C
Cytokine-cytokine receptor interaction
GM-CSF; CCL13; CCR9A; TNFSF18; FASLG; TGFB2; Il23a; Il12b; CCL4; BMPR1AA; FLT3
Developmental Biology
SIAH2; KLB; CAP1; EFNA1B; IL17RD; INSM1B; PITPNA; ITGB1B.1; KCNQ2; RASGRP4
EPH-Ephrin signaling
EFNA2; ARPC5; EFNB3B; ARPC1A; EFNA1; CFL1; MYL12B; EFNA1A; ARPC1B; EFNA3B
EPHA-mediated growth cone collapse
KDR; EPHA4A; EFNA4; EFNA1; EFNA2; SHB; EPHA10; MYL9; EFNA1A; EFNA3
Endocytosis
NEDD4L; RAB11FIP5; CYTH4; ARF3; ARPC5A; ARRB1; CHMP6; SPG20A; BIN1B; RAB11FIP1
Focal adhesion
RAC2; VEGFB; MAPK9; ITGB8; PIP5K1C; MYLPF; CCND2; ACTN2; PIK3CB; MYL12.2
Id Signaling Pathway
TCF3B; ACVRL1; TCF12; MSC; IFI16; KDR; MYOG; MYOD1; PAX2; ELK3

Protein Function

Kdr has several biochemical functions, for example, ATP binding, growth factor binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kdr itself. We selected most functions Kdr had, and list some proteins which have the same functions with Kdr. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF11; IP6K3; MKNK2; GTF2F2B; HSPH1; NME6; BMPR1A; MAP2K6; OAS1; DDX31
Function growth factor binding
Related Protein NRP2; ERBB3; SDCBP; ACVR1C; TEK; REG3B; ACVR2A; RPL37; NRP1; LTBP2
Function integrin binding
Related Protein ICAM3; PTPN2; ITGB6; EMP2; Tcam1; P4HB; DMP1; ILK; FAP; S1PR3
Function protein binding
Related Protein FANCD2; BTF3; ZCCHC11; UNC13B; SHARPIN; RB1; SH3RF1; NDC80; PVRL4; FAM195B
Function protein tyrosine kinase activity
Related Protein KIAA1804; EPHA4B; FGR; FGFR2; PTK2; RET; LCK; MAP2K7; SRC; SRMS
Function vascular endothelial growth factor binding
Related Protein KDR; PDGFRA; NRP1; PDGFRB
Function vascular endothelial growth factor-activated receptor activity
Related Protein PDGFRA; NRP2; KDR; NRP1B; NRP2A; NRP2B; NRP1A; FLT3; NRP1; FLT4

Kdr Related Articles

Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
Verma, VK; Kamaraju, SR; et al. Fluorescent magnetic iron oxide nanoparticles for cardiac precursor cell selection from stromal vascular fraction and optimization for magnetic resonance imaging. INTERNATIONAL JOURNAL OF NANOMEDICINE 10:711-726(2015).