TIGIT
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Official Full Name
T cell immunoreceptor with Ig and ITIM domains
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Overview
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. -
Synonyms
TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Canine
- Cynomolgus
- Cynomolgus / Rhesus macaque
- Cynomolgus monkey
- Cynomolgus Monkey
- Cynomolgus/Rhesus macaque
- Human
- Mouse
- Mus musculus (Mouse)
- Rabbit
- Rat
- CHO
- CHO Cells
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human cells
- Mammalian cells
- C
- 6His
- Avi
- Fc
- hFc
- His
- mFc
- DDK|His
- DYKDDDDK
- Fc Chimera
- Flag
- GST
- His (Fc)
- His(C
- ter)
- His\Avi
- His|Avi
- His|T7
- SUMO
- HlgG1 Fc
- human|IgG1|Fc
- IgG2a Fc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- TIGIT Related Articles
- TIGIT Related Research Area
TIGIT involved in several pathways and played different roles in them. We selected most pathways TIGIT participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with TIGIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | MAG;PVR;ICAM3;HLA-DRB3;CLDN6;NCAM1;CDH1;CLDN22;PVRL3B |
TIGIT has several biochemical functions, for example, cell adhesion molecule binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIGIT itself. We selected most functions TIGIT had, and list some proteins which have the same functions with TIGIT. You can find most of the proteins on our site.
Function | Related Protein |
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cell adhesion molecule binding | ITGB1;DSG2;MSN;CRTAM;CXADR;CADM1;CADM2A;PVRL2L;PVR |
protein binding | GSK3A;MAP2K4;ZFP488;CSNK2A2;ITGB3;ATXN3;FES;CDR2;SNRNP70 |
protein homodimerization activity | SDCBP;S100A11;TNNC1;IZUMO1;HNF1A;LMLN;MAP3K5;DDX1;SPATA24 |
receptor activity | KLRB1F;CD244;CALCR;NLGN3A;TEK;CXCR3;VAC14;PLAUR;THBD |
receptor binding | PICK1;CXCL10;LRRC4B;TNFSF18;NRG1;RSPO2;FGF12A;SRI;NRG4 |
TIGIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIGIT here. Most of them are supplied by our site. Hope this information will be useful for your research of TIGIT.
CD226; PVR; PVRL2; PVRL4; PVRL3
- Q&As
- Reviews
Q&As (5)
Ask a questionTIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.
TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.
TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.
TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.
As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.
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