Mouse Anti-CFH Monoclonal Antibody
Cat.No. : | DMABT-H19244 |
Product Overview : | Mouse Anti-CFH Monoclonal Antibody |
- Specification
- Gene Information
- Related Products
Antigen Description : | Factor H, a 155 kD soluble glycoprotein, is a member of the regulators of complement activation family and is a complement control protein. It circulates in human plasma at a concentration of 500-800 mg/ml that provides critical negative regulation to the alternative pathway of complement cascade. Factor H is secreted by Kupffer cells, hepatocytes, vascular endothelial cells, and platelets. Overactive factor H may result in reduced complement activity on pathogenic cells, increasing susceptibility to microbial infections. Underactive factor H may result in increased complement activity on healthy host cells, resulting in autoimmune diseases. |
Target : | CFH |
Immunogen : | Human Complement Factor H |
Host : | Mouse |
Isotype : | IgG1, kappa |
species : | Human |
Conjugation : | N/A |
Applications : | ELISA,WB |
Preparation : | The antibody was purified by affinity chromatography. |
Usage recommendation : | Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 2-8 μg/ml is recommended. To obtain a linear standard curve, serial dilutions of Factor H recombinant protein ranging from 78 to 5000 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application. |
Concentration : | 0.5 mg/ml |
Storage : | The antibody solution should be stored undiluted at 4 °C. |
Size : | 50 μg;500 μg |
Gene Name : | CFH complement factor H [ Homo sapiens ] |
Official Symbol : | CFH |
Synonyms : | CFH; complement factor H; H factor2(complement) , HF, HF1, HF2; age related maculopathy susceptibility 1; ARMS1; beta 1H; FHL1; H factor 2 (complement); HUS; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; H factor2(complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1; FH; HF; HF1; HF2; AHUS1; AMBP1; ARMD4; CFHL3; MGC88246; |
Gene ID : | 3075 |
mRNA Refseq : | NM_000186 |
Protein Refseq : | NP_000177 |
MIM : | 134370 |
UniProt ID : | P08603 |
Chromosome Location : | 1q32 |
Pathway : | Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Regulation of Complement cascade, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
CFH-1168H | Recombinant Human CFH Protein, GST-Tagged | +Inquiry |
Cfh-1612M | Recombinant Mouse Cfh Protein, His (Fc)-Avi-tagged | +Inquiry |
Cfh-761M | Recombinant Mouse Cfh Protein, His-tagged | +Inquiry |
CFH-762H | Recombinant Human CFH Protein, His-tagged | +Inquiry |
CFH-763H | Recombinant Human CFH Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
CFH-23H | Active Native Human Complement factor H | +Inquiry |
CFH-115H | Active Native Human Factor H | +Inquiry |
◆ Lysates | ||
CFH-2409HCL | Recombinant Human CFH cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in CFH increase the risk of aHUS, affecting complement regulation and leading to kidney damage.
CFH controls the complement system, preventing its overactivation and protecting against immune damage.
CFH modulates the immune response to bacterial infections, balancing defense mechanisms.
CFH deficiency is linked to AMD, due to impaired regulation of the complement pathway in the retina.
CFH shields host cells from complement-mediated injury, maintaining tissue integrity.
CFH regulates inflammation and maintains immune balance, crucial for preventing excessive immune responses.
Changes in CFH function can impact kidney health, potentially leading to renal diseases due to altered complement activity.
Customer Reviews (3)
Write a reviewExceptional protein expression optimization support, highly appreciated assistance.
Precise protein quantification, ensures data accuracy in our research.
Timely antibody validation, an invaluable asset for our laboratory.
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