Native Bovine BGLAP

• Cat.No.: BGLAP-8519B
• Product Overview: Native Bovine BGLAP is purified from Osteocalcin is prepared from bovine bone generally as described by Price et al. This involves demineralization in EDTA, size exclusion and ion exchange chromatography.

Specification

• Description: Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone. Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29. The secondary structure is highly calcium dependent and contains 14% α-helix, 20% β-sheet and 67% random form in the presence of calcium, and 1% α-helix, 20% β-sheet and 79% random form in the absence of calcium.
• Source: Bovine
• Species: Bovine
• Form: 50% glycerol/H2O (v/v)
• Molecular Mass: 5,800
• Purity: >95% by SDS-PAGE
• Storage: -80℃ aqueous; -20℃ glycerol

Gene Information

• Gene Name: BGLAP bone gamma-carboxyglutamate (gla) protein [ Bos taurus ]
• Official Symbol: BGLAP
• Synonyms: BGLAP; BOS_2768; BGP; bone Gla protein; gamma-carboxyglutamic acid-containing protein; osteocalcin
• Gene ID: 281646
• mRNA Refseq: NM_174249.2
• Protein Refseq: NP_776674.1
• UniProt ID: P02820
• Function: calcium ion binding