Native Human glu-Plasminogen
Cat.No. : | PLG-54H |
Product Overview : | Native glu-plasminogen is prepared from fresh frozen human plasma by a modification of the procedure of Castellino, utilizing gel filtration and affinity chromatography. |
- Specification
- Gene Information
- Related Products
Description : | Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 μM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These five triple-looped, three disulfide bridged, kringle regions are homologous to the kringle domains in t-PA, u-PA and prothrombin. Plasminogen contains one high affinity (Kd=9x10-6M) and four low affinity (Kd=5x10-3M) lysine binding sites. The high affinity binding site resides within the first kringle region of plasminogen. The interaction of plasminogen with fibrin and α2-antiplasmin is mediated by these lysine binding sites. Native glu-plasminogen (Mr=88,000) is readily converted to Lys-77-plasminogen (Mr=83,000) by plasmin hydrolysis of the Lys76-Lys77 peptide bond. Elastase catalyzed cleavage of the Val441-Val442 peptide bond of glu-plasminogen yields a functionally active zymogen termed Val-442 plasminogen or mini-plasminogen. The conversion of plasminogen to plasmin occurs by a variety of mechanisms, but all result in hydrolysis of the Arg560-Val561 peptide bond of plasminogen, yielding two chains which remain covalently associated by a disulfide bond. |
Species : | Human |
Form : | 50% (vol/vol) glycerol/H2O |
Molecular Mass : | 88,000 |
Purity : | >95% by SDS-PAGENOT tissue/cell culture grade. Not tested for endotoxin. |
Storage : | The plasminogen is supplied in 50% (vol/vol) glycerol/H2O for storage at -20°C . |
Gene Name : | PLG plasminogen [ Homo sapiens ] |
Official Symbol : | PLG |
Synonyms : | PLG; plasminogen; plasmin; DKFZp779M0222; |
Gene ID : | 5340 |
mRNA Refseq : | NM_001168338 |
Protein Refseq : | NP_001161810 |
MIM : | 173350 |
UniProt ID : | P00747 |
Chromosome Location : | 6q26 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; |
Function : | apolipoprotein binding; cell surface binding; peptidase activity; protein binding; protein domain specific binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
PLG-6846M | Recombinant Mouse PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
PLG-4182R | Recombinant Rat PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
Plg-2673C | Recombinant Chicken Plg Protein, His-tagged | +Inquiry |
PLG-3290R | Recombinant Rhesus Macaque PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
PLG-134H | Recombinant Human PLG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
Plg-291M | Active Native Mouse glu-Plasminogen | +Inquiry |
PLG-27925TH | Native Human PLG | +Inquiry |
PLG-252H | Active Native Human Plasminogen | +Inquiry |
◆ Lysates | ||
PLG-3109HCL | Recombinant Human PLG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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