"CTSL2" Related Products

Recombinant Human Cathepsin L2, His-tagged

Cat. No. : CTSL2-681H
Product Overview : Recombinant human procathepsin V produced ininsect cellsis fused to a His-tag. 37kDa (SDS-PAGE).
Description : Recombinant glycosylated procathepsin V cloned from human cDNA and purified as full-length proenzyme. Can be activated in one step. Cathepsin V, a member of the papain family of cysteine proteases, has 78% identity to cathepsin L, but unlike cathepsin L is not widely expressed, being localized to thymus, testis, corneal epithelium, and macrophages. It is a strong elastase, also cleaving proteins such as the invariant chain (Ii), plasminogen, and kininogen. It is implicated in disease states such as cancer, angiogenesis, atherosclerosis, and myasthenia gravis.
Source/Host : insect cells.
Application : Study enzyme kinetics, cleave target substrates and screen for inhibitors.
Concentration : 0.5mg/ml.
Purity : ≥90%.
Specific Activity : 436 U/μg protein. One unit will hydrolyze one pmole Z-Leu-Arg-AMC substrate (Prod. No. BML-P229, 25 μM) per minute at 25°C, in 25mM NaOAc pH 5.5, 100mM NaCl, 1.0mM DTT.
Formulation : Liquid. In 25mM TRIS-HCl, pH 8.0, containing 100mM sodium chloride, 0.05% Tween-20 and 10% glycerol.
Long Term Storage : -80°C.
Use/Stability : Avoid extended periods unfrozen. This enzyme is stable for 6 months when stored as received under the above conditions.
Handling : After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Gene Name : CTSL2 cathepsin L2 [ Homo sapiens ]
Synonyms : CTSL2; cathepsin L2; CTSU; CTSV; CATL2; MGC125957; EC3.4.22.43; Cathepsin L2; Cathepsin V; Cathepsin U; UNQ268/PRO305
Gene ID : 1515
mRNA Refseq : NM_001333
Protein Refseq : NP_001324
MIM : 603308
UniProt ID : O60911
Chromosome Location : 9q22.2
Pathway : Lysosome
Function : cysteine-type endopeptidase activity; peptidase activity; protein binding

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