Recombinant Human MUC1 Protein, His-Avi-tagged, Biotinylated

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Recombinant Human MUC1 Protein, His-Avi-tagged, Biotinylated

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Cat.No. : MUC1-619H
Product Overview : Biotinylated Human Mucin-1 (890-1158), His,Avitag is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).
Description : Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
Source : HEK293
Species : Human
Tag : His-Avi
Predicted N Terminal : Ser 890 (partial α chain) & Ser 1098 (partial β chain)
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Molecular Mass : This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.3 kDa (partial α chain) and 10.2 kDa (partial β chain). The protein migrates as 45-70 kDa (partial α chain) and 7 kDa and 14-15 kDa (partial β chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ser 890 - Gly 1158
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE :

Gene Name : MUC1 mucin 1, cell surface associated [ Homo sapiens ]
Official Symbol : MUC1
Synonyms : Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM; CA 15-3; Episialin
Gene ID : 4582
mRNA Refseq : NM_001018016
Protein Refseq : NP_001018016
MIM : 158340
UniProt ID : P15941

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