| Species : |
O'nyong-nyong virus |
| Source : |
E.coli |
| Tag : |
His |
| Protein Length : |
338-691 a.a. |
| Description : |
Spike glycoprotein E2: Plays a role in viral attachment to target host cell, by binding to the cell receptor. Synthesized as a p62 precursor which is processed by furin at the cell membrane just before virion budding, giving rise to E2-E1 heterodimer. The p62-E1 heterodimer is stable, whereas E2-E1 is unstable and dissociate at low pH. p62 is processed at the last step, presumably to avoid E1 fusion activation before its final export to cell surface. E2 C-terminus contains a transitory transmembrane that would be disrupted by palmitoylation, resulting in reorientation of the C-terminal tail from lumenal to cytoplasmic side. This step is critical since E2 C-terminus is involved in budding by interacting with capsid proteins. This release of E2 C-terminus in cytoplasm occurs lately in protein export, and precludes premature assembly of particles at the endoplasmic reticulum membrane. |
| Purity : |
>95% , based on SDS PAGE |
| Applications : |
WB standard, antibody ELISA, immunogen, etc. |
| Notes : |
For research use only, not for use in diagnostic procedures. |
| Stability : |
Stable for 6 months at -20 centigrade from the date of shipment. Nonhazardous. |
| Storage Buffer : |
Each vial contains 100 µg of protein in PBS with 8M Urea. |
