ca9
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  • Official Full Name
  • carbonic anhydrase IX
  • Background
  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas.
  • Synonyms
  • CA9; carbonic anhydrase IX; MN; CAIX; carbonic anhydrase 9; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonic dehydratase; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; MN/CA9
Cat.#:CA9-1544CATag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CA9 protein, Fc-tagged, APC labeled
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Cat.#:CA9-1544CPTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CA9 protein, Fc-tagged, R-PE labeled
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Cat.#:CA9-890HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9 protein, Fc-tagged, APC labeled
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Cat.#:CA9-890HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9 protein, Fc-tagged, R-PE labeled
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Cat.#:CA9-0250HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CA9 Protein, GST-Tagged
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Cat.#:CA9-2272HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9 Protein, MYC/DDK-tagged
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Cat.#:CA9-1544CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CA9 Protein, Fc-tagged
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Cat.#:CA9-10627HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA9 protein, GST-tagged
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Cat.#:CA9-256HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9, His tagged
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Cat.#:CA9-27269THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CA9
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Cat.#:CA9-7844HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA9 protein, His-tagged
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Cat.#:CA9-890HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9, Fc tagged
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Cat.#:Car9-914MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Car9, His tagged
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Cat.#:CA9-1039CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CA9 Protein, His-tagged
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Cat.#:CA9-3065HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA9 cell lysate
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Cat.#:CA9-2189MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CA9 cell lysate
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Cat.#:CA9-1447CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CA9 cell lysate
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Involved Pathway

CA9 involved in several pathways and played different roles in them. We selected most pathways CA9 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nitrogen metabolism
CA6; CA4B; CAR3; CA1; GLUL; CA7; GLULB; CAR6; Car8; GLUD1B

Protein Function

CA9 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA9 itself. We selected most functions CA9 had, and list some proteins which have the same functions with CA9. You can find most of the proteins on our site.
Function
Related Protein
Function carbonate dehydratase activity
Related Protein Car8; CAR6; CA12; CAR15; CA15A; CA4; CA15C; Car14; CA8; CA14
Function zinc ion binding
Related Protein TRIM43C; NANOS2; KDM5B; SCEL; ADAMTSL1; CTCF; CA15B; RORAB; USP33; TCEA2

CA9 Related Articles

Kato, Y; Hagiwara, M; et al. TNF-alpha augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1. BMC MICROBIOLOGY 14:-(2014).
Fujihara, R; Usui, M; et al. Tumor necrosis factor-alpha enhances RANKL expression in gingival epithelial cells via protein kinase A signaling. JOURNAL OF PERIODONTAL RESEARCH 49:508-517(2014).