CD33 Protein, CD33 CD33 molecule


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Official Full Name CD33 CD33 molecule
Background CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC
Synonyms CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3
    • Species :
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • GST
    • Avi
    • HIgG
    • LIgG2b Fc
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus CD33-1081C Recombinant Cynomolgus CD33 Protein (Met1-Gly248), His-tagged, Biotinylated HEK293 His
    Human CD33-176HA Recombinant Human CD33 protein, Fc-tagged, APC labeled NS0 Fc
    Human CD33-176HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human CD33-342H Recombinant Human CD33 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc
    Human CD33-459HA Recombinant Human CD33 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD33-459HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD33-551H Recombinant Human CD33 Protein (Met1-His259) HEK293 N/A
    Mouse Cd33-6889MA Recombinant Mouse Cd33 protein, Fc-tagged, APC labeled HEK293 Fc
    Mouse Cd33-6889MP Recombinant Mouse Cd33 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD33-833HA Recombinant Human CD33 protein, Fc/His-tagged, APC labeled HEK293 Fc/His
    Human CD33-833HP Recombinant Human CD33 protein, Fc/His-tagged, R-PE labeled HEK293 Fc/His
    Mouse CD33-835M Recombinant Mouse CD33 Protein (Met1-Glu240) HEK293 N/A
    Human CD33-0790H Recombinant Human CD33 Protein Wheat Germ N/A
    Human CD33-0791H Recombinant Human CD33 Protein, GST-Tagged Wheat Germ GST
    Human CD33-10946H Recombinant Human CD33, GST-tagged E.coli GST
    Human CD33-176H Recombinant Human CD33, Fc Chimera NS0 Fc Chimera
    Human CD33-234H Recombinant Human CD33, His tagged Human Cell Fc
    Human CD33-240H Recombinant Human CD33 Protein, hIgG-His-tagged Insect Cell His/HIgG
    Human CD33-267H Recombinant Human CD33 protein, His-tagged HEK293 His
    Human CD33-268H Recombinant Human CD33 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD33-3097H Recombinant Human CD33 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD33-313H Recombinant Human CD33, Fc tagged Human Cell N/A
    Human CD33-459H Recombinant Human CD33 Molecule, Fc Chimera HEK293 Fc
    Human CD33-487H Recombinant Human CD33 molecule, His-tagged E.coli His
    Human CD33-5088H Recombinant Human CD33, His-tagged E.coli His
    Human CD33-675H Recombinant Human CD33, Fc-tagged, Biotinylated Human Cell Fc
    Human CD33-7815H Recombinant Human CD33 protein, His-tagged HEK293 His
    Human CD33-833H Recombinant Human CD33 Protein, Fc/His-tagged HEK293 Fc/His
    Human CD33-978HCL Recombinant Human CD33 cell lysate Human Cell N/A
    Mouse CD33-1808MCL Recombinant Mouse CD33 cell lysate Human Cell N/A
    Mouse Cd33-5169M Recombinant Mouse Cd33, His tagged Human Cell His
    Mouse Cd33-586M Recombinant Mouse Cd33 protein, His-tagged E.coli His
    Mouse Cd33-6889M Recombinant Mouse CD33 Antigen, Fc-tagged Human Cell Fc
    Cynomolgus Monkey CD33-181C Recombinant Cynomolgus CD33, His-tagged Human Cell His

    CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage Fcer2a; CD36; GM2002; HLA-DRB3; ITGB3; FCGR1; HLA-DRB5; ITGA4; IL6R; CD1D

    CD33 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding MRC2; MGAT2; KLRA8; CLEC4D; NCAN; LGALS7B; NOMO1; GALNTL1; OLR1; ASGR1
    protein binding EDA; FAM131B; INPP5D; FMR1; PTGES3; MBP; C1orf50; FNTA; UBOX5; ZNF263
    receptor activity VMN1R41; GRIN2BB; ANTXR2; GFRA4A; NLGN1; SLC1A5; ITGB1B; THBD; ADCYAP1R1; KRT1

    CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.

    PTPN6; PTPN11; KRT31; KRT40; HERC3

    Loke, J; Khan, JN; et al. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. ANNALS OF HEMATOLOGY 94:361-373(2015).
    Xu, LM; Zhang, Y; et al. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. INTERNATIONAL IMMUNOPHARMACOLOGY 24:463-473(2015).

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