cxcl13
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 13
  • Background
  • C-X-C motif chemokine 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) and B cell-attracting chemokine 1 (BCA-1), is a 109 amino acid secreted protein that belongs to the intercrine alpha (chemokine CxC) family. It functions as a chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. CXCL13 does not induce calcium release in B-lymphocytes. It binds to BLR1/CXCR5. The highest level of CXCL13 is found in the liver, followed by spleen, lymph node, appendix and stomach. Low level of CXC13 is found in salivary gland, mammary gland, and fetal spleen.
  • Synonyms
  • ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); B-lymphocyte chemoattractant; C-X-C motif chemokine 13; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13
Cat.#:CXCL13-2161HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL13 Protein, GST-tagged
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Cat.#:CXCL13-1322RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque CXCL13 Protein
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Cat.#:CXCL13-024HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL13 Protein
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Cat.#:CXCL13-123HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged
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Cat.#:CXCL13-124HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 13, MIgG2a Fc-tagged
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Cat.#:CXCL13-2437HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human CXCL13, His-tagged
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Cat.#:CXCL13-26649THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL13
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Cat.#:CXCL13-4101MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCL13 Protein
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Cat.#:Cxcl13-7160MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl13 protein, His & GST-tagged
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Cat.#:Cxcl13-83MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C Motif) Ligand 13
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Cat.#:Cxcl13-49RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl13 protein, His/GST-tagged
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Cat.#:Cxcl13-7161RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl13 protein, His & GST-tagged
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Cat.#:Cxcl13-79RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl13 Protein, His-GST-tagged
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Cat.#:CXCL13-1169CTag:His
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CXCL13 Protein, His-tagged
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Cat.#:CXCL13-432CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CXCL13 Protein, His-tagged
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Cat.#:CXCL13-1108RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCL13 Protein, His-tagged
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Cat.#:CXCL13-299CTag:FC/His
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CXCL13, His tagged
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Cat.#:CXCL13-7170HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCL13 293 Cell Lysate
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Involved Pathway

CXCL13 involved in several pathways and played different roles in them. We selected most pathways CXCL13 participated on our site, such as CXCR3-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CXCR3-mediated signaling events
MAPKAP1; DNM1; CXCL13
Chemokine receptors bind chemokines
CCR9; AMCF-II; CXCL13; CXCL11.8; CCR1; CXCR6; CCL35.2; CX3CR1; CCRL2; CCBP2
Chemokine signaling pathway
GNAI3; PPBP; CCL2; CXCL16; JAK2; GNG12; CCL5; PXN; ITK; AMCF-II
Class A/1 (Rhodopsin-like receptors)
APLN; EDNRAB; OPN4.1; GPR68; NMB; EDNRB; MLN; NTS; CCR3; PPY
Cytokine-cytokine receptor interaction
CNTF; IL11; TGFB1A; CXCR4A; IFNA5; TP-1; PDGFB; CCL1; PRLR; PDGFAA
G alpha (i) signalling events
PENKB; OXER1; GPR55A; RGS20; SOUL3; FPR-RS6; ANXA1C; LPAR5A; PNOC; OXGR1
GPCR downstream signaling
ADRA2C; OR4D2; OPN1SW1; RHOL; PENKB; APLNR; TAS2R16; DRD5; OR7D2; NMBB
GPCR ligand binding
GPR31; TAS2R13; EDN1; TAS2R3; OPN4B; TAC3; GPR120; GPBAR1; S1PR1; RLN2

Protein Function

CXCL13 has several biochemical functions, for example, CCR10 chemokine receptor binding, CXCR3 chemokine receptor binding, CXCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL13 itself. We selected most functions CXCL13 had, and list some proteins which have the same functions with CXCL13. You can find most of the proteins on our site.
Function
Related Protein
Function CCR10 chemokine receptor binding
Related Protein CCL25; CXCL13; CCL19
Function CXCR3 chemokine receptor binding
Related Protein CXCL11; CXCL10; CXCL11.8; PF4; CXCL9; CXCL13
Function CXCR5 chemokine receptor binding
Related Protein CXCL13
Function chemokine activity
Related Protein CXCL2; CCL33.3; CKLF; PF4; CCL22; CCL3; CCL14; CXCL3; CCL19A.1; CCL6
Function fibroblast growth factor binding
Related Protein CXCL13; GPC1; S100A13; FGFRL1; SCN5A; HSPA9; FGFR2; TGFBR3; FGFBP1; FIBPB
Function heparin binding
Related Protein ECM2; SLIT1A; FGF2; PLA2G5; CTGF; ADAMTS1; PF4V1; FBLN7; POSTN; GREM2
Function protein heterodimerization activity
Related Protein ADIPOR2; UGT1A4; DDX1; SEPHS1; IRAK2; NFKB1; DMRT3A; BCL2A1A; HIST1H4J; DRD2
Function receptor agonist activity
Related Protein SFRP2; VEGFA; WNT5A; WNT3; GREM1; GAS6; WNT1; NODAL; CXCL13; WNT2

Interacting Protein

CXCL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL13.
EEF1G; ftsK

CXCL13 Related Articles

Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).

CXCL13 Related Gene Family

GPCRs Chemokines Cytokines