icos
Share
  • Official Full Name
  • inducible T-cell co-stimulator
  • Background
  • The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
  • Synonyms
  • ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850
Cat.#:ICOS-1015RTag:HlgG1 Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus ICOS Protein (Met1-Lys140), HlgG1 Fc-tagged
+Inquiry
Cat.#:ICOS-378HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS Protein, His-tagged
+Inquiry
Cat.#:ICOS-827MTag:RlgG Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged
+Inquiry
Cat.#:ICOS-1531HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICOS, MIgG2a Fc-tagged
+Inquiry
Cat.#:ICOS-1532HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICOS, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:ICOS-1533HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICOS, HIgG1 Fc-tagged
+Inquiry
Cat.#:ICOS-1628HTag:N/A
Source (Host):NSOSpecies:Human
Product nameRecombinant Human ICOS protein
+Inquiry
Cat.#:ICOS-175HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS Protein, Fc/His-tagged
+Inquiry
Cat.#:ICOS-185HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ICOS, Fc-tagged
+Inquiry
Cat.#:ICOS-3243HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS, Fc-His tagged
+Inquiry
Cat.#:ICOS-3244HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS Protein, Fc-tagged
+Inquiry
Cat.#:ICOS-390HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS protein
+Inquiry
Cat.#:ICOS-7659HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICOS protein, His & GST-tagged
+Inquiry
Cat.#:Icos-1747MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Inducible T-cell Co-stimulator
+Inquiry
Cat.#:Icos-1821MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Icos, MIgG2a Fc-tagged
+Inquiry
Cat.#:Icos-33MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Icos protein, His-tagged
+Inquiry
Cat.#:Icos-6951MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Icos, Fc tagged
+Inquiry
Cat.#:ICOS-2981RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ICOS Protein
+Inquiry
Cat.#:Icos-7660RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Icos protein, His-tagged
+Inquiry
Cat.#:Icos-8799RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Icos, Fc tagged
+Inquiry
Cat.#:ICOS-1661RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICOS Protein
+Inquiry
Cat.#:ICOS-1662RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICOS Protein, hIgG1-tagged
+Inquiry
Cat.#:ICOS-1663RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICOS Protein, hIgG4-tagged
+Inquiry
Cat.#:ICOS-2187RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ICOS Protein, His-tagged
+Inquiry
Cat.#:ICOS-3729CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ICOS
+Inquiry
Cat.#:ICOS-2444HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICOS cell lysate
+Inquiry
Cat.#:ICOS-1724MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ICOS cell lysate
+Inquiry
Cat.#:ICOS-1195RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ICOS cell lysate
+Inquiry

Involved Pathway

ICOS involved in several pathways and played different roles in them. We selected most pathways ICOS participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
OCLNA; CLDN5A; CLDN8; CLDNA; ITGA8; NRXN3; ITGA9; CDH3; CLDN20; CLDN18
T cell receptor signaling pathway
KRAS; PPP3CB; DBNLB; CD247; PAK1; TNF; DLG1; CD8B1; PAK7; IL5
Intestinal i
IL15RA; CXCL12B; CD28; H2-AA; PIGR; CD40; MADCAM1; H2-AB1; Il2; MHC2DAB
ne network for IgA production
ICOS; H2-AB1; LTBR; CCL28; HLA-DRB4; HLA-DMA; CD40LG; TGFB1; MADCAM1; TNFSF13
Primary i
RFX5; ICOS; IKBKG; ORAI1; AICDA; TAP2; CD8A; TAP1; CD79A; AIRE
nodeficiency
RFXANK; CD8A; RAG2; BLNK; AIRE; PTPRC; IKBKG; Cd79a, Cd79b; CD40; CD8B1

Interacting Protein

ICOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOS here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOS.
WIF1

ICOS Related Articles

Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).

ICOS Related Gene Family

Immunoglobulins