KITLG

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KITLG

Official Full Name KIT ligand
Background This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins.
Synonyms KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; Clo; Con; Gb; SLF; Sl; contrasted; cloud gray; grizzle-belly; hematopoietic growth factor KL; stem cell factor Location: 10 51.4 cM
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Equine
    • Feline
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Swine
    • Source :
    • Barley Grain
    • CHO
    • Drosophila S2 Cell
    • E.coli
    • HEK293
    • HEK293F
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • P.pastoris
    • Yeast
    • Tag :
    • Fc
    • His
    • Avi
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken KITLG-39C Recombinant Chicken KITLG Protein Yeast
    Human KITLG-2056H Recombinant Human KITLG Protein, His-tagged HEK293 His
    Human KITLG-325H Recombinant Human KITLG Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human KITLG-435HG GMP Recombinant Human KITLG protein, His-tagged HEK293 His
    Mouse KITLG-829M Recombinant Mouse KITLG Protein (Met1-Ala189), His-tagged, Biotinylated Insect Cell His
    Human KITLG-036E Recombinant Human KITLG (26-189aa), Met tagged E.coli N/A
    Human KITLG-055H Recombinant Human KITLG Protein, His-tagged HEK293 His
    Human KITLG-1245H Recombinant Human KIT Ligand HEK293 N/A
    Human KITLG-19H Recombinant Human KITLG protein E.coli N/A
    Human KITLG-20H Recombinant Human KITLG, HIgG1 Fc-tagged CHO Fc
    Human KITLG-21H Recombinant Human KITLG, HIgG1 Fc-tagged, mutant CHO Fc
    Human KITLG-22H Recombinant Human KITLG, MIgG2a Fc-tagged CHO Fc
    Human KITLG-262H Recombinant Human KITLG, StrepII-tagged Human Cell Strep II
    Human KITLG-306H Recombinant Human KIT Ligand E.coli N/A
    Human KITLG-33H Recombinant Human KITLG, His-tagged Barley Grain His
    Human KITLG-4339HG GMP Recombinant Human KITLG protein E.coli N/A
    Human KITLG-436H Recombinant Human KIT Ligand Drosophila S2 Cell N/A
    Human KITLG-483H Recombinant Human KITLG, Fc-tagged CHO Fc
    Human KITLG-520H Recombinant Human KITLG protein HEK293
    Human KITLG-521H Recombinant Human KITLG, His tagged Human Cell N/A
    Human KITLG-522H Recombinant Human KITLG Protein, His-tagged, Biotinylated HEK293 His
    Human KITLG-558H Recombinant Human KITLG, His tagged Insect Cell His
    Human KITLG-571HCL Recombinant Human KITLG cell lysate Insect Cell N/A
    Human KITLG-60H Recombinant Human KIT Ligand, His-tagged Insect Cell His
    Human KITLG-9128H Recombinant Human KITLG P.pastoris N/A
    Human KITLG-961H Recombinant Human KITLG Protein E.coli N/A
    Human SCF-116H Human Stem Cell Factor (rDNA derived) Reference standard N/A
    Mouse Kitl-042E Recombinant Mouse Kitl (26-189aa) E.coli N/A
    Mouse Kitl-1243M Recombinant Mouse Kit Ligand, His-tagged Hordeum Vulgare His
    Mouse Kitl-208M Recombinant Mouse Kitl P.pastoris N/A
    Mouse Kitl-307M Recombinant Mouse Kit Ligand E.coli N/A
    Mouse Kitl-501M Recombinant Mouse Interleukin Kitl, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Kitl-502M Recombinant Mouse Kitl, MIgG2a Fc-tagged CHO Fc
    Mouse Kitl-575M Recombinant Mouse Kitl, His tagged Insect Cell His
    Mouse Kitl-577M Recombinant Mouse Kitl protein, His-tagged, Biotinylated. HEK293 His
    Mouse Kitl-61M Recombinant Mouse Kit Ligand E.coli N/A
    Mouse KITL-8666M Recombinant Mouse KITL Protein Mammalian Cell His
    Mouse Kitlg-34M Recombinant Mouse Kitlg, His-tagged Barley Grain His
    Mouse Kitlg-486M Recombinant Mouse Kitlg, Fc-tagged CHO Fc
    Mouse Kitlg-5252M Recombinant Mouse Kit Ligand Mouse N/A
    Mouse KITLG-583MCL Recombinant Mouse KITLG cell lysate Insect Cell N/A
    Rat Kitlg-267R Recombinant Rat Kitlg, MIgG2a Fc-tagged CHO Fc
    Rat KITLG-3265R Recombinant Rat KITLG Protein Mammalian Cell His
    Rat Kitlg-5267R Recombinant Rat KIT Ligand E.coli N/A
    Rat Kitlg-584R Recombinant Rat Kitlg protein E.coli N/A
    Rat Kitlg-62R Recombinant Rat Kit Ligand E.coli N/A
    Rat Kitlg-63R Recombinant Rat Kitlg E.coli N/A
    Rat Kitlg-793R Recombinant Rat Kitlg protein, His-tagged E.coli His
    Canine KITLG-4388C Recombinant Canine KITLG Protein Yeast N/A
    Canine KITLG-572D Recombinant Canine KITLG protein E.coli N/A
    Bovine KITLG-4321B Recombinant Bovine KITLG Protein Yeast N/A
    Chicken KITLG-3748C Recombinant Chicken KITLG Mammalian Cell His
    Chicken KITLG-38C Recombinant Chicken KITLG Protein E.coli N/A
    Rabbit KITLG-4356R Recombinant Rabbit KITLG Protein Yeast N/A
    Swine KITLG-4355S Recombinant Swine KITLG Protein Yeast N/A
    Feline KITLG-4379F Recombinant Feline KITLG Protein Yeast N/A
    Equine KITLG-4392E Recombinant Equine KITLG Protein Yeast N/A
    Pig KITLG-450P Recombinant Pig KITLG protein, His-tagged HEK293F His

    KITLG involved in several pathways and played different roles in them. We selected most pathways KITLG participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KITLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PIK3R5; RALBP1; MET; KSR1; PDGFRA; Fgf15; PGF; RRAS2; RAC2; RAP1A
    Rap signaling pathway FGF21; PDGFC; FARP2; ANGPT1; PIK3R2; RAC1; AKT1; LAT; PLCB2; PLCB3
    Cytokine-cytokine receptor interaction KITB; TNFRSF4; CXCR4A; IL23; CLCF1; IL1RAP; MET; CXCL1; IL5; CXCL9
    Phospholipase D signaling pathway HRAS; SHC4; PIP5K1C; INS2; CYTH4; PIP5K1A; AGTR1B; PIK3CD; AVPR1B; LPAR5
    PIK-Akt signaling pathway PIK3CD; LAMA2; ITGA2B; PPP2CB; NRAS; FN1; G6PC3; PPP2R2C; ITGB8; CCND1
    Hematopoietic cell lineage CSF1R; CD9; MS4A1; TFRC; THPO; GM2002; KITLG; CD8A; CSF3R; CD59A
    Melanogenesis ADCY1B; FZD5; HRASA; RAF1B; CAMK2G; WNT2BA; PRKACA; FZD7; MITFB; EDNRB2
    Pathways in cancer RAC2; BRAF; STAT5B; PDGFB; FGF13; LPAR5; LAMA4; TGFB2; RBX1; LPAR6

    KITLG has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KITLG itself. We selected most functions KITLG had, and list some proteins which have the same functions with KITLG. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CCL4; IFNPHI1; PRL7D1; BMP7; Ccl27a; IL17A/F1; IFNG1-1; GREM1A; OSTN; NODAL
    growth factor activity VHL; Artn; ENDOU; FGF8B; GDF1; FBRS; WISP3; FGF1A; RABEP2; CSF3
    protein binding FBXO2; LATS1; MAP2K5; MAGEA8; SGCA; MAPRE3; VDAC2; PRR3; NR5A1; EDNRA
    stem cell factor receptor binding Kitl; SPRED2; SPRED1; KITLGA; KITLGB; KITLG

    KITLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KITLG here. Most of them are supplied by our site. Hope this information will be useful for your research of KITLG.

    KIT; FLT3LG

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