kitlg
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  • Official Full Name
  • KIT ligand
  • Background
  • This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins.
  • Synonyms
  • KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; Clo; Con; Gb; SLF; Sl; contrasted; cloud gray; grizzle-belly; hematopoietic growth factor KL; stem cell factor Location: 10 51.4 cM
Cat.#:KITLG-2056HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG Protein, His-tagged
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Cat.#:KITLG-325HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG Protein, His & Avi-tagged, Biotinylated
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Cat.#:KITLG-829MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse KITLG Protein (Met1-Ala189), His-tagged, Biotinylated
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Cat.#:KITLG-4388CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine KITLG Protein
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Cat.#:KITLG-4321BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine KITLG Protein
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Cat.#:KITLG-38CTag:
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken KITLG Protein
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Cat.#:KITLG-4356RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit KITLG Protein
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Cat.#:KITLG-4355STag:
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine KITLG Protein
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Cat.#:KITLG-4379FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline KITLG Protein
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Cat.#:KITLG-4392ETag:
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine KITLG Protein
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Cat.#:KITLG-306HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIT Ligand
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Cat.#:Kitl-307MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Kit Ligand
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Cat.#:KITLG-055HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human KITLG Protein, His-tagged
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Cat.#:KITLG-19HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human KITLG protein
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Cat.#:KITLG-20HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human KITLG, HIgG1 Fc-tagged
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Cat.#:KITLG-21HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human KITLG, HIgG1 Fc-tagged, mutant
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Cat.#:KITLG-22HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human KITLG, MIgG2a Fc-tagged
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Cat.#:KITLG-262HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG, StrepII-tagged
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Cat.#:KITLG-33HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human KITLG, His-tagged
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Cat.#:KITLG-436HTag:N/A
Source (Host):S2 Insect cellsSpecies:Human
Product nameRecombinant Human KIT Ligand
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Cat.#:KITLG-483HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human KITLG, Fc-tagged
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Cat.#:KITLG-520HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG
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Cat.#:KITLG-521HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG, His tagged
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Cat.#:KITLG-522HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KITLG Protein, His-tagged, Biotinylated
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Cat.#:KITLG-558HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KITLG, His tagged
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Cat.#:KITLG-60HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KIT Ligand, His-tagged
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Cat.#:KITLG-9128HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human KITLG
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Cat.#:KITLG-961HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KITLG Protein
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Cat.#:Kitl-208MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Kitl
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Cat.#:Kitl-501MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin Kitl, MIgG2a Fc-tagged, mutant
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Cat.#:Kitl-502MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Kitl, MIgG2a Fc-tagged
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Cat.#:Kitl-575MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Kitl, His tagged
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Cat.#:Kitl-576MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kitl protein, His-tagged
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Cat.#:Kitl-577MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Kitl protein, His-tagged, Biotinylated.
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Cat.#:Kitl-61MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Kit Ligand
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Cat.#:KITL-8666MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KITL Protein
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Cat.#:Kitlg-34MTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Mouse
Product nameRecombinant Mouse Kitlg, His-tagged
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Cat.#:Kitlg-486MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Kitlg, Fc-tagged
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Cat.#:Kitlg-267RTag:Fc
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Kitlg, MIgG2a Fc-tagged
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Cat.#:KITLG-3265RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KITLG Protein
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Cat.#:Kitlg-584RTag:
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rat Kitlg protein
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Cat.#:Kitlg-62RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Kit Ligand
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Cat.#:Kitlg-63RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Kitlg
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Cat.#:Kitlg-793RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Kitlg protein, His-tagged
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Cat.#:KITLG-572DTag:
Source (Host):E.coliSpecies:Canine
Product nameRecombinant Canine KITLG protein
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Cat.#:KITLG-3748CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KITLG
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Cat.#:KITLG-450PTag:His
Source (Host):HEK293FSpecies:Pig
Product nameRecombinant Pig KITLG protein, His-tagged
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Cat.#:Kitlg-5252MTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Kit Ligand
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Cat.#:Kitlg-5267RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat KIT Ligand
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Cat.#:KITLG-036ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KITLG (26-189aa), Met tagged
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Cat.#:Kitl-042ETag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Kitl (26-189aa)
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Cat.#:KITLG-1245HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIT Ligand
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Cat.#:Kitl-1243MTag:His
Source (Host):Hordeum vulgare (barley grain)Species:Mouse
Product nameRecombinant Mouse Kit Ligand, His-tagged
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Cat.#:KITLG-571HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KITLG cell lysate
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Cat.#:KITLG-583MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse KITLG cell lysate
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Cat.#:KITLG-4339HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human KITLG protein
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Cat.#:SCF-116HTag:
Source (Host):Species:Human
Product nameHuman Stem Cell Factor (rDNA derived) Reference standard
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Involved Pathway

Kitlg involved in several pathways and played different roles in them. We selected most pathways Kitlg participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kitlg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
KSR1; PLCG2; FIGF; RASAL1; GNB1; PIK3CG; PRKACG; FGF6; FLT1; FGF7
Rap signaling pathway
KRIT1; GRIN1; FGFR2; RHOA; IGF1; PDGFB; LCP2; MLLT4; HRAS; INS
Cytokine-cytokine receptor interaction
CXCL10; IFNA10; TGFBR2; IL3RA; IFNA3; CXCR4A; PF4V1; GHR; CCL4L1; PRLRA
Phospholipase D signaling pathway
Adcy4; PDGFC; PLA2G4A; GRM4; PRKCA; AVPR1A; PLCB2; HRAS; PTK2B; FYN
PIK-Akt signaling pathway
RBL2; IFNA17; TNXB; RPS6KB2; TCL1A; YWHAB; Pdgfa&Pdgfb; IRS1; IL6R; MTOR
Hematopoietic cell lineage
CD1C; CR2; CD9; EPO; FLT3; Flt3l; GP5; IL1R2; Itgam&Itgb2; CD1A
Melanogenesis
GSK3B; FZD9; GNAI2; FZD8B; KIT; FZD3B; MAP2K2; PRKACG; MAP2K1; FZD8A
Pathways in cancer
Fgf15; WNT8A; FGF9; ITGAV; RARB; PDGFRA; FADD; HGF; MITF; GNAI1

Protein Function

Kitlg has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kitlg itself. We selected most functions Kitlg had, and list some proteins which have the same functions with Kitlg. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein EDN1; IFNA10; IL5; IL33; TNFSF12; IL31; Flt3l; TNFSF13B; SPP1; CSF1A
Function growth factor activity
Related Protein FGF8B; Pdgfa&Pdgfb; HDGF; FGF22; HBEGF; AMH; PRL2C2; LIF; HBEGFA; GDF11
Function protein binding
Related Protein SLC25A10; ADRM1; POU2F1; BRD9; SGOL2; CHRD; IL12B; COX4I2; PSMD7; AHI1
Function stem cell factor receptor binding
Related Protein Kitl; SPRED2; KITLGB; SPRED1; KITLGA; KITLG

Interacting Protein

Kitlg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kitlg here. Most of them are supplied by our site. Hope this information will be useful for your research of Kitlg.
KIT; FLT3LG