MMP2 Protein, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

MMP2

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MMP2

Official Full Name matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.coli Cells
    • HEK293
    • Human
    • Human Cell
    • Human Fibroblasts
    • Human Synovial Fibroblasts
    • Mammalian Cell
    • Mouse Fibroblast
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-0320C MMP2 Inhibitor Screening Assay Kit N/A
    Rat MMP2-657R Recombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged E.coli His/SUMO
    Human MMP2-8392HA Recombinant Human MMP2 protein, GST-tagged, APC labeled E.coli Cells GST
    Human MMP2-8392HP Recombinant Human MMP2 protein, GST-tagged, R-PE labeled E.coli Cells GST
    Human MMP2-150H Recombinant Human MMP2 protein Yeast N/A
    Human MMP2-151H Recombinant Human Matrix Metallopeptidase 2, Hemopexin-like Domain E.coli N/A
    Human MMP2-169H Recombinant Human MMP2 yeast N/A
    Human MMP2-1715H Recombinant Human Matrix Metallopeptidase 2 (Gelatinase A, 72 KDa Gelatinase, 72 KDa Type IV Collagenase) Human N/A
    Human MMP2-1716H Recombinant Human Matrix Metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Human N/A
    Human MMP2-182H Recombinant Human MMP2 Protein, His-tagged HEK293 His
    Human MMP2-201H Recombinant Human MMP2 protein E.coli N/A
    Human MMP2-2380HCL Recombinant Human MMP2 cell lysate Human Cell N/A
    Human MMP2-244H Recombinant Human MMP2 protein, His-tagged E.coli His
    Human MMP2-29435TH Recombinant Human MMP2, His-tagged E.coli His
    Human MMP2-29475TH Native Human MMP2 N/A
    Human MMP2-408H Recombinant Human MMP2 NSO N/A
    Human Mmp2-416M Recombinant Mouse Mmp2, His-tagged Human Cell His
    Human MMP2-450H Recombinant Human matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), His-tagged E.coli His
    Human MMP2-46H Native Human MMP-2 Human Synovial Fibroblasts N/A
    Human MMP2-47H Native Human MMP-2/TIMP-2 Complex Human Fibroblasts N/A
    Human MMP2-5051H Recombinant Human MMP2, His-tagged E.coli His
    Human MMP2-5425H Recombinant Human MMP2 Protein, GST-tagged Wheat Germ GST
    Human MMP2-562H Recombinant Human MMP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MMP2-808H Recombinant Human Matrix Metallopeptidase 2 Sf9 Insect Cell N/A
    Human MMP2-8392H Recombinant Human MMP2, GST-tagged E.coli GST
    Human MMP2-889H Recombinant Human MMP2, None tagged Human Cell N/A
    Human MMP2-890H Recombinant Human MMP2 protein, His-tagged HEK293 His
    Mouse Mmp2-1019M Recombinant Mouse Mmp2 Protein, His-tagged HEK293 His
    Mouse Mmp2-245M Recombinant Mouse Mmp2 protein, His-tagged E.coli His
    Mouse Mmp2-415M Recombinant Mouse Matrix Metallopeptidase 2 NSO N/A
    Mouse Mmp2-44M Recombinant Mouse MMP-2/TIMP-2 Complex Mouse Fibroblast N/A
    Mouse MMP2-8455M Native Mouse MMP2 Mouse Fibroblast N/A
    Rat Mmp2-246R Recombinant Rat Mmp2 protein, His-tagged E.coli His
    Rat MMP2-28059TR MMP2 protein(Rat) N/A
    Rat MMP2-3715R Recombinant Rat MMP2 Protein Mammalian Cell His
    Chicken MMP2-5990C Recombinant Chicken MMP2 Mammalian Cell His
    Zebrafish MMP2-9789Z Recombinant Zebrafish MMP2 Mammalian Cell His

    MMP2 involved in several pathways and played different roles in them. We selected most pathways MMP2 participated on our site, such as Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Leukocyte transendothelial migration PTK2B; NOX1; PIK3R5; PRKCB; CXCR4; MYL5; PIK3CD; MYL10; CLDN16; GNAI1
    GnRH signaling pathway CALML3; GNRHR2; PRKCB; PRKCDA; HRASB; RAF1; SOS1; CALM1B; PLCB2; MMP14A
    Estrogen signaling pathway GABBR2; FOS; GNAI1; PIK3R1; CREB3L2; PRKACB; FKBP5; CREB3L3; CREB3L1; PRKACG
    Pathways in cancer IL6; Fasl; FGF3; GNAI2; CBL; LAMB4; NTRK1; ERBB2; PIK3CD; NFKBIA
    Proteoglycans in cancer ITGB3; WNT9B; WNT6; WNT11; CBL; MAP2K1; WNT10B; DROSHA; PXN; WNT3A
    Bladder cancer MAP2K2; IL-8; E2F3; MMP1; DAPK1; TYMP; MMP9; MDM2; CDK4; RB1

    MMP2 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP2 itself. We selected most functions MMP2 had, and list some proteins which have the same functions with MMP2. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity MMP9; BMP1A; MMP23B; ADAM8A; THOP1; Adam6; ADAM1B; BMP1; PAPPA; ADAM12
    metallopeptidase activity ANPEPA; DPP3; ADAMTS4; XPNPEP2; ADAM21; AGBL4; MMP1A; ADAM1B; ADAM23; XPNPEP3
    protein binding PUM2; DEFB121; SPI1; HMOX1; STRADA; PPP2CA; CCP110; CUL9; MST1; SMARCC1
    serine-type endopeptidase activity FURINB; PCSK1; C1S; MCPT2; MST1; LOC100686744; TMPRSS4B; RHBDD1; PRSS52; TMPRSS13A
    zinc ion binding RNF4; UQCRC1; NR6A1; Car12; YAF2; ADH5; ADAMTS13; ZACN; KIAA0913; AFG3L2

    MMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP2.

    collagen_i_human; PCSK9; collagen_i_pig; TIMP2; Pcsk9; SCUBE3; USP12; A2M; LDLR; TGFB1; HSP90AA1; BACE1

    Ghosh, A; Pechota, A; et al. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. HUMAN PATHOLOGY 46:284-294(2015).
    Ding, XF; Yang, DR; et al. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals. MOLECULAR CANCER 14:-(2015).

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