mmp9
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  • Official Full Name
  • matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); B/MMP9; AW743869; pro-MMP-9
Cat.#:MMP9-5438HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP9 Protein, GST-tagged
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Cat.#:MMP9-560HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9 Protein, MYC/DDK-tagged
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Cat.#:Mmp9-561MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mmp9 Protein, His-tagged
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Cat.#:MMP9-709HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 9
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Cat.#:MMP9-774HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9, Catalytic Domain, T7-tagged
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Cat.#:MMP9-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human matrix metallopeptidase 9, His-tagged
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Cat.#:MMP9-155HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9 protein
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Cat.#:MMP9-166HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9
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Cat.#:MMP9-29699THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9, His-tagged
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Cat.#:MMP9-3829HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9, GST-tagged
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Cat.#:MMP9-410HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human MMP9 protein
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Cat.#:MMP9-429HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MMP9 protein, His-tagged
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Cat.#:MMP9-44HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9, His-tagged
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Cat.#:MMP9-4893HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9 protein, His-tagged
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Cat.#:MMP9-661HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9, None tagged
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Cat.#:MMP9-77HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP9, His-tagged
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Cat.#:MMP9-811HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9, His tagged
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Cat.#:MMP9-812HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9, His-tagged
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Cat.#:Mmp9-1188MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mmp9, None tagged
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Cat.#:Mmp9-2793MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp9 protein, His-tagged
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Cat.#:Mmp9-417MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Matrix Metallopeptidase 9
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Cat.#:Mmp9-431MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Mmp9 protein, His-tagged
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Cat.#:Mmp9-1195RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Mmp9, His tagged
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Cat.#:Mmp9-2794RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp9 protein, His-tagged
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Cat.#:MMP9-3720RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP9 Protein
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Cat.#:Mmp9-436RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Mmp9 protein, His-tagged
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Cat.#:Mmp9-537RTag:His
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Mmp9, His-tagged
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Cat.#:MMP9-2795RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit MMP9 protein, His & T7-tagged
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Cat.#:MMP9-6233CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MMP9
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Cat.#:MMP9-12341ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MMP9
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Cat.#:MMP9-2792CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle MMP9 protein, His & T7-tagged
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Cat.#:Pro-MMP9-109HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pro-matrix metallopeptidase 9, His-tagged
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Cat.#:MMP9-29698THTag:
Source (Host):Species:Human
Product nameNative Human MMP9
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Cat.#:MMP9-30035THTag:
Source (Host):Species:Human
Product nameNative Human MMP9
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Cat.#:MMP9-38HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human MMP-9
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Cat.#:MMP9-39HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human MMP-9/Lipocalin Complex
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Cat.#:MMP9-40HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human MMP-9/Lipocalin/TIMP-1 Complex
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Cat.#:MMP9-41HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human MMP-9/TIMP-1 Complex
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Cat.#:MMP9-9810Tag:N/A
Source (Host):human bloodSpecies:Human
Product nameNative Human MMP9
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Cat.#:MMP9-2560HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP9 cell lysate
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Cat.#:MMP9-2026MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MMP9 cell lysate
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Cat.#:MMP9-1940RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MMP9 cell lysate
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Cat.#:Kit-3100Tag:
Source (Host):Species:
Product nameMMP-9 Fluorimetric Assay Kit
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Cat.#:Kit-2130Tag:
Source (Host):Species:
Product nameMMP-9 Inhibitor Screening Kit
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Cat.#:CSC-P0962Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP9 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0963Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP9 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0964Tag:
Source (Host):Species:Human
Product nameAnti-Human MMP9 scFv Stable Cell Line-CHO
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Involved Pathway

MMP9 involved in several pathways and played different roles in them. We selected most pathways MMP9 participated on our site, such as TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP9 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TNF signaling pathway
CREB5; NFKB1; LIF; RPS6KA4; MMP14; CASP10; IL1B; CXCL2; FAS; CCL2
Leukocyte transendothelial migration
CLDN8; MYL12A; MYL2; CLDN16; PTK2; MYL9; CLDN2; CYBB; PIK3R3; ITGB2L
Estrogen signaling pathway
ATF4; HSPA2; CREB5; PIK3R3; GNAQ; HSPA1L; PRKCD; GRM1; HSPA1A; PIK3R2
Hepatitis B
BAX; ATP6AP1; AKT1; IFN-a; MAP3K1; TLR3; FAS; IFNA16; IFNA12; IFNA14
Pathways in cancer
AGTR1B; PDGFRA; PRKACA; LEF1; FGF11; LAMB4; ITGA2; RAC1; MAPK3; TCF7L2
Transcriptional misregulation in cancer
NUPR1; CCNT2; EYA1; HOXA10; H3F3B; MEF2C; CD14; BCL6; TCF3; DOT1L
Proteoglycans in cancer
NANOG; THBS1; FZD7; WNT4; WNT5A; CBLB; PIK3R3; STAT3; WNT6; TGFB2
MicroRNAs in cancer
TNN; IGF2BP1; SLC7A1; BCL2L2; NRAS; ATM; PDGFB; MCL1; STMN1; STAT3
Bladder cancer
MDM2; THBS1; EGF; VEGFA; E2F3; RASSF1; TRP53; MYC; HBEGF; DAPK2

Protein Function

MMP9 has several biochemical functions, for example, collagen binding, endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP9 itself. We selected most functions MMP9 had, and list some proteins which have the same functions with MMP9. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein MMP9; SMAD3; ADAM9; ITGA9; ACHE; GP6; PDGFA; NID1; GP5; CTSL1
Function endopeptidase activity
Related Protein PSMB2; ECE1; PSMA8; APH1B; KLK1B26; ACE2; PSEN1; KLK1B3; CASP1; PSMA6
Function identical protein binding
Related Protein SH3GLB1; MYD88; USP15; TLE1; FNBP1; ATL2; SERPINA1A; BCAT1; IIGP1; TRIM55
Function metalloendopeptidase activity
Related Protein HE2; MMP28; ADAMTS10; ADAM8; ADAMTS5; PAPPA; ADAM33; ADAMTS13; PAPPAB; ADAM32
Function metallopeptidase activity
Related Protein ADAM2; ERAP2; ADAMTS13; MMP1A; ADAM5; ADAMTS15A; AGBL1; MMP13A; DPEP3; NPEPPS
Function protein binding
Related Protein RGS3; AKR1B10; SPG7; KLRD1; ATG4B; ATP6V1G1; TRIM32; STK38; TRIM72; CLOCKA
Function zinc ion binding
Related Protein PGLYRP4; BTR02; NR1H4; ZNF598; P2RX4; AICDA; MMP30; BTR06; BTR09; DTX3

Interacting Protein

MMP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP9.
VCAN; MEP1A; MEP1B; TIMP1; SRGN; ELN; SCUBE3; TGFB1; q7cje7_yerpe; ITGA5

MMP9 Related Articles

Liu, ZK; Dou, CW; et al. RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMY9. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1710-1720(2015).
Muradashvili, N; Benton, RL; et al. Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. METABOLIC BRAIN DISEASE 30:411-426(2015).