MMP9

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MMP9

Official Full Name matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Synonyms MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); B/MMP9; AW743869; pro-MMP-9
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Blood
    • Human Cell
    • Human Neutrophil
    • Mammalian Cell
    • NS0
    • NSO
    • Wheat Germ
    • Yeast
    • Yeast(Pichia pastor)
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-3100 MMP-9 Fluorimetric Assay Kit N/A
    Human MMP9-105H Recombinant Human matrix metallopeptidase 9, His-tagged E.coli His
    Human MMP9-1443H Recombinant Human Matrix Metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), His-tagged Human His
    Human MMP9-155H Recombinant Human MMP9 protein E.coli N/A
    Human MMP9-166H Recombinant Human MMP9 E.coli N/A
    Human MMP9-2560HCL Recombinant Human MMP9 cell lysate Human Cell N/A
    Human MMP9-29698TH Native Human MMP9 N/A
    Human MMP9-29699TH Recombinant Human MMP9, His-tagged E.coli His
    Human MMP9-30035TH Native Human MMP9 N/A
    Human MMP9-3829H Recombinant Human MMP9, GST-tagged E.coli GST
    Human MMP9-38H Native Human MMP-9 Human Neutrophil N/A
    Human MMP9-39H Native Human MMP-9/Lipocalin Complex Human Neutrophil N/A
    Human MMP9-40H Native Human MMP-9/Lipocalin/TIMP-1 Complex Human Neutrophil N/A
    Human MMP9-410H Recombinant Human MMP9 protein CHO N/A
    Human MMP9-41H Native Human MMP-9/TIMP-1 Complex Human Neutrophil N/A
    Human MMP9-429H Recombinant Human MMP9 protein, His-tagged Yeast(Pichia pastor) His
    Human MMP9-44H Recombinant Human MMP9, His-tagged E.coli His
    Human MMP9-4893H Recombinant Human MMP9 protein, His-tagged HEK293 His
    Human MMP9-5438H Recombinant Human MMP9 Protein, GST-tagged Wheat Germ GST
    Human MMP9-560H Recombinant Human MMP9 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MMP9-661H Recombinant Human MMP9, None tagged Human Cell N/A
    Human MMP9-709H Recombinant Human Matrix Metallopeptidase 9 NS0 N/A
    Human MMP9-774H Recombinant Human MMP9, Catalytic Domain, T7-tagged E.coli T7
    Human MMP9-77H Recombinant Human MMP9, His-tagged E.coli His
    Human MMP9-811H Recombinant Human MMP9, His tagged Human Cell His
    Human MMP9-812H Recombinant Human MMP9 protein, His-tagged HEK293 His
    Human MMP9-9810 Native Human MMP9 Human Blood N/A
    Human Pro-MMP9-109H Recombinant Human Pro-matrix metallopeptidase 9, His-tagged E.coli His
    Mouse Mmp9-1188M Recombinant Mouse Mmp9, None tagged Human Cell N/A
    Mouse MMP9-2026MCL Recombinant Mouse MMP9 cell lysate Human Cell N/A
    Mouse Mmp9-2793M Recombinant Mouse Mmp9 protein, His-tagged E.coli His
    Mouse Mmp9-417M Recombinant Mouse Matrix Metallopeptidase 9 NSO N/A
    Mouse Mmp9-431M Recombinant Mouse Mmp9 protein, His-tagged Yeast His
    Mouse Mmp9-561M Recombinant Mouse Mmp9 Protein, His-tagged HEK293 His
    Rat Mmp9-1195R Recombinant Rat Mmp9, His tagged Human Cell His
    Rat MMP9-1940RCL Recombinant Rat MMP9 cell lysate Human Cell N/A
    Rat Mmp9-2794R Recombinant Rat Mmp9 protein, His-tagged E.coli His
    Rat MMP9-3720R Recombinant Rat MMP9 Protein Mammalian Cell His
    Rat Mmp9-436R Recombinant Rat Mmp9 protein, His-tagged Yeast His
    Rat Mmp9-537R Recombinant Rat Mmp9, His-tagged NS0 His
    Rabbit MMP9-2795R Recombinant Rabbit MMP9 protein, His & T7-tagged E.coli His/T7
    Chicken MMP9-6233C Recombinant Chicken MMP9 Mammalian Cell His
    Zebrafish MMP9-12341Z Recombinant Zebrafish MMP9 Mammalian Cell His
    Cattle MMP9-2792C Recombinant Cattle MMP9 protein, His & T7-tagged E.coli His/T7
    Kit-2130 MMP-9 Inhibitor Screening Kit N/A

    MMP9 involved in several pathways and played different roles in them. We selected most pathways MMP9 participated on our site, such as TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF signaling pathway MAP3K5; RELA; CXCL5; MMP3; MAPK3; TAB2; SOCS3; BAG4; PTGS2; ITCH
    Leukocyte transendothelial migration ROCK2; ITGB2; PTK2; CXCR4; CLDN15; PLCG2; CLDN22; NIPAL1; CLDN16; RAP1B
    Estrogen signaling pathway AKT1; HSPA6; HSPA8; PRKACG; PIK3CA; PIK3R1; PIK3R2; PRKACA; SHC3; PIK3R3
    Hepatitis B MAVS; MAPK3; FAS; IFNA16; MAP3K1; PIK3R2; CCND1; ATP6AP1; PIK3R5; TGFBR1
    Pathways in cancer FGFR1; STAT5B; SOS1; TGFBR1; PTEN; FGF19; PDGFRB; PTCH2; RAC2; ABL1
    Transcriptional misregulation in cancer ID2; MEIS1; FCGR1A; IL6; CCNA1; TRAF1; HIST2H3C2; NCOR1; HOXA11; PBX1
    Proteoglycans in cancer ACTG1; WNT2B; RAC1; RRAS2; ERBB2; ERBB3; WNT7A; TIMP3; CAV3; ANK1
    MicroRNAs in cancer BCL2L2; TTC6; STAT3; MTOR; TNN; RDX; KRAS; PDCD4; CDC25B; TRIM71
    Bladder cancer DAPK1; CCND1; MMP1; MMP9; RASSF1; HBEGF; MAP2K1; RAF1; NRAS; CDH1

    MMP9 has several biochemical functions, for example, collagen binding, endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP9 itself. We selected most functions MMP9 had, and list some proteins which have the same functions with MMP9. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding GP5; SMAD4; RELL2; GPR56; SERPINH1B; CHADL; Pdgfa&Pdgfb; PCOLCE2; GP6; CCBE1
    endopeptidase activity PSMB9B; KLK1B26; PSMA2; MMP12; KLK1B11; KLK1B5; PSMB8; PSMB5; PSMA4; Ren1
    identical protein binding KCNRG; COL2A1; ECI1; MUL1A; PKD2L1; GNPNAT1; RASSF3; EPS15; YWHAZ; MRFAP1L1
    metalloendopeptidase activity C6AST1; GM12824; PAPPAB; MMP13; MMP1; OMA1; MMP23BB; AFG3L2; MMP30; MEP1A.1
    metallopeptidase activity ADAM20; ADAM17; XPNPEP3; ANPEPA; PAPPAB; MMP13A; CNDP1; AQPEP; MEP1A.1; ANPEPB
    protein binding FOS; WLS; CCDC64; MAPK7; GSK3B; AHNAK; XPO5; RCC1; EMP1; FLI1
    zinc ion binding NANOS2; KDM4C; RASSF1; ZDHHC16; PHC2; CSRP2; PARP1; TADA2B; TRIM30A; MORC4

    MMP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP9.

    VCAN; MEP1A; MEP1B; TIMP1; SRGN; ELN; SCUBE3; TGFB1; q7cje7_yerpe; ITGA5

    Liu, ZK; Dou, CW; et al. RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMY9. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1710-1720(2015).
    Muradashvili, N; Benton, RL; et al. Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. METABOLIC BRAIN DISEASE 30:411-426(2015).

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