Ngf
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Official Full Name
nerve growth factor (beta polypeptide) -
Overview
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this genes expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] -
Synonyms
NGF;nerve growth factor (beta polypeptide);NGFB;HSAN5;Beta-NGF;beta-nerve growth factor;nerve growth factor, beta subunit
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Dog
- Rat
- Pig
- Rhesus macaque
- Horse
- Cattle
- Guinea pig
- Vulpes vulpes (Red fox)
- CHO
- E.coli
- HEK293
- Mammalian Cells
- Human
- Submaxillary gland
- Mouse Submaxillary Gland
- Yeast
- Mouse
- Bacillus subtilis
- Human Cells
- Fc
- Non
- GST
- His
- Avi
- SUMO
- DDK
- Myc
- Flag
Involved Pathway
Ngf involved in several pathways and played different roles in them. We selected most pathways Ngf participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ngf were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | BAX,PRKACB,PIK3R2,LMNB1,CASP8,BADB,DERL3,IRF4,AKT1,CRADD |
| Ras signaling pathway | FGF19,FGF8,VEGFB,ABL2,ANGPT4,PRKACA,FGF6,VEGFC,LAT,MET |
| PIK-Akt signaling pathway | ITGA10,ITGA2,Itga10&Itgb1,PKN2,GNB1,EIF4E2,INS2,Ifna15,GH2,PGF |
| MAPK signaling pathway | PPM1A,ECSIT,GADD45AA,SRFA,PRKACAB,IKBKB,PRKCA,NFKB2,HSPA8,TGFB3 |
| Neurotrophin signaling pathway | NFKBIB,ZFP110,RPS6KA1,RHOA,TP53,TRP53,PIK3CA,KRAS,NRAS,MAPK13 |
| Inflammatory mediator regulation of TRP channels | CALML5,PLA2G6,PLCB4,MAP2K3,CYP2C50,PRKACB,PIK3CG,PLA2G4A,Adcy4,PPP1CB |
| Rap signaling pathway | PGF,BCAR1,KRAS,PRKCG,F2RL3,FGFR4,VEGFA,MAP2K3,MET,RRAS |
Protein Function
Ngf has several biochemical functions, for example, growth factor activity,metalloendopeptidase inhibitor activity,nerve growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ngf itself. We selected most functions Ngf had, and list some proteins which have the same functions with Ngf. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor signaling protein activity | Siglece,ADCYAP1,TGFBR1,BAG4,RAF1B,FLRT3,DCLK1,DAXX,DOK2,KLK1B3 |
| growth factor activity | FGF18B,Fgf15,IL10,GDNFA,CECR1,FGF3,PDGFC,AMH,BMP10,EFEMP1 |
| metalloendopeptidase inhibitor activity | WFIKKN2,RECK,BST2,TIMP2,SPOCK1,COL4A3,TIMP2A,TIMP1,TIMP3,FETUB |
| nerve growth factor receptor binding | NTF7 |
| protein binding | RAB7A,TRAF2,DPM2,ZNF266,PTPN7,SMIM3,TANK,LGI1,PPP6C,GABARAPL1 |
Interacting Protein
Ngf has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ngf here. Most of them are supplied by our site. Hope this information will be useful for your research of Ngf.
NTRK1;Ngfr;NGFR;SORT1;SORCS3
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References
- Gezginci-Oktayoglu, S; Karatug, A; et al. Nerve Growth Factor Neutralization Suppresses beta-Cell Proliferation Through Activin A and Betacellulin. PANCREAS 44:243-249(2015).
- Paoletti, F; Malerba, F; et al. A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1854:187-197(2015).
