Recombinant Human PDCD1 Protein, His\Avi-tagged
Cat.No. : | PDCD1-187H |
Product Overview : | Biotinylated Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His, Avi tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
Source : | Human Cells |
Species : | Human |
Tag : | His\Avi |
Form : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
AA Sequence : | Pro21-Gln167 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Shipping : | Ambient |
Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens (human) ] |
Official Symbol : | PDCD1 |
Synonyms : | Programmed cell death protein 1; hPD-1; PDCD1; CD279; PD1; PD-1; CD279; SLEB2; hSLE1 |
Gene ID : | 5133 |
mRNA Refseq : | NM_005018.3 |
Protein Refseq : | NP_005009.2 |
MIM : | 600244 |
UniProt ID : | Q15116 |
Products Types
◆ Recombinant Protein | ||
PDCD1-1033R | Active Recombinant Rat PDCD1 protein(Met1-Gln167), hFc-tagged | +Inquiry |
PDCD1-370M | Active Recombinant Mouse PDCD1 Protein, Fc & Avi-tagged, Biotinylated | +Inquiry |
PDCD1-698M | Recombinant Mouse PDCD1 Protein | +Inquiry |
PDCD1-266H | Recombinant Human PDCD1 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
Pdcd1-4730M | Recombinant Mouse Pdcd1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
PDCD1-2628MCL | Recombinant Mouse PDCD1 cell lysate | +Inquiry |
PDCD1-001RCL | Recombinant Rat PDCD1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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