Recombinant Human POLG protein

• Cat.No.: POLG-1525H
• Product Overview: Recombinant full length human DNA polymerase gamma catalytic subunit.

Specification

• Description: This is the POLG gene product, the catalytic subunit of DNA polymerase gamma. Pol gamma is the mitochondrial replication and repair DNA polymerase. Defects in the POLG gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Pol gamma is also a target of various nucleotide derivatives.
• Source: E. coli
• Species: Human
• Form: 20 mM
  Tris-HCl, (pH7.5), 200 mM NaCl, 1 mM β-
  mercaptoethanol, and 10% glycerol
• Molecular Mass: 140 kDa
• Storage: Stable for 2 years at -70 centigrade from date of
  shipment. Aliquot to avoid repeated
  freezing and thawing.

Gene Information

• Gene Name: POLG polymerase (DNA directed), gamma [ Homo sapiens ]
• Official Symbol: POLG
• Synonyms: POLG; polymerase (DNA directed), gamma; DNA polymerase subunit gamma-1; POLG1; POLGA; PolG-alpha; PolG, catalytic subunit; mitochondrial DNA polymerase catalytic subunit; PEO; MDP1; SCAE; MIRAS; SANDO; MTDPS4A; MTDPS4B; FLJ27114
• Gene ID: 5428
• mRNA Refseq: NM_001126131
• Protein Refseq: NP_001119603
• MIM: 174763
• UniProt ID: P54098