il12a
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  • Official Full Name
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
  • Background
  • Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
  • Synonyms
  • IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
Cat.#:IL12A-4327HGTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL12A protein
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Cat.#:IL12A-310HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A Protein
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Cat.#:IL12A & IL12B-357HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B protein
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Cat.#:IL12A-113HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A
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Cat.#:IL12A-165HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRcombinant Human IL12A, His-Fc-tagged
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Cat.#:IL12A-26973THTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL12A
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Cat.#:IL12A-27HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IL12A/IL12B protein
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Cat.#:IL12A-29635THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A, His-tagged
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Cat.#:IL12A-309HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A, Fc tagged
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Cat.#:IL12A-315HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A, His tagged
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Cat.#:IL12A-47HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL12A
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Cat.#:IL12A-587HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A protein, His-tagged
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Cat.#:IL12A-850HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A protein, His & S-tagged
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Cat.#:IL35-12HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A/IL27B protein, Fc-tagged
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Cat.#:Il12a-228MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a, P80
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Cat.#:Il12a-851MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12a protein, His & T7-tagged
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Cat.#:IL12A-3025RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL12A Protein
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Cat.#:Il12a-853RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il12a protein, His & T7-tagged
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Cat.#:Il12b&Il12a-748RTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Rat
Product nameRecombinant Rat Il12b&Il12a
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Cat.#:IL12A-190CTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A
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Cat.#:IL12A-191CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A, Fc-tagged
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Cat.#:IL12A-2229RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL12A Protein, His-tagged
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Cat.#:IL12A-7141CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL12A
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Cat.#:IL12A-1637ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL12A
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Cat.#:IL12A-852PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL12A protein, His & T7-tagged
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Cat.#:IL12B&IL12A-903FTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Feline
Product nameRecombinant Feline IL12B&IL12A
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Cat.#:IL12-21HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-12
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Cat.#:IL12A-112HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A
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Cat.#:IL12A-219HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IL12A
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Cat.#:IL12A-42HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A, His-tagged
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Cat.#:Il12a-209MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a
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Cat.#:Il12a-210MTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a, P35-P40
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Cat.#:Il12a-211MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a, P35-P40
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Cat.#:Il12a-226MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a
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Cat.#:Il12a-227MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a, P40
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Cat.#:IL12A & IL12B-1908HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B cell lysate
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Cat.#:IL12A&IL27B-853HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A&IL27B cell lysate
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Cat.#:IL12A-2435HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A cell lysate
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Cat.#:IL12A & IL12B-1779MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1780MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1781MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1782MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A & IL12B cell lysate
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Cat.#:IL12A-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A cell lysate
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Cat.#:IL12A-129HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human IL12A Protein
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Involved Pathway

IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR3.2; IL1RAP; CCL4; CCL14; IL-8; CNTF; TGFB1A; GH1; IL8L1; LEPA
Toll-like receptor signaling pathway
MAPK11; IFNPHI3; CCL3; IFNA21; TICAM2; IFNAR1; IL-8; TOLLIP; CCL3L1; TLR3
RIG-I-like receptor signaling pathway
MAPK11; MAPK14B; TANK; CASP10; ISG15; IL12BA; TRAF3; IFNA1; IL12B; RELA
Jak-STAT signaling pathway
SOCS3B; IL2RA; CISHB; IL19; PIK3CA; IL-15RA; STAT5A; MPL; JAK2A; IFNA13
Type I diabetes mellitus
IL12A; GAD2; PTPRN; FAS; ICA1; Il2; IL1A; H2-AA; INS; HLA-F
Pertussis
FOS; C5; CALM3; C2; CXCL5; CALML3; C1QB; IL1B; IRF8; IRAK1
Legionellosis
HSPA2; ITGB2; IL12A; IL-8; NAIP6; IL12B; NAIP7; RELA; CD14; TLR5
Leishmaniasis
NCF2; HLA-DOA; FCGR2C; NFKB1; FCGR1A; HLA-DMA; MAPK1; PTPN6; HLA-DRB3; ITGAM
Chagas disease (American trypanosomiasis)
TLR9; CASP8; NFKB1; TGFB3; GNAS; IL12B; SERPINE1; MYD88; PIK3R1; FASLG
African trypanosomiasis
PLCB4; PLCB3; IL12A; IL10; FAS; VCAM1; THOP1; F2RL1; APOL1; HBB-B2
Malaria
Ccl12; HBA1; HBB-B1; IL-8; THBS2; MYD88; SDC2; ICAM1; LRP1; ITGAL
Toxoplasmosis
GNAI2; MAPK3; LAMA5; TYK2; LDLR; LAMB3; STAT1; AKT1; HLA-DRB3; TNF
Amoebiasis
PIK3CA; SERPINB1C; PIK3R5; CTSG; SERPINB2; HSPB1; COL27A1; LAMA1; CD1D; ACTN2
Tuberculosis
ATP6V0A1; RAB7A; CLEC4E; BAD; IFNA21; RAB5B; IL1B; PPP3R2; NFYC; TGFB1
Measles
FAS; STAT1; IFNA4; IRAK4; MYD88; SH2D1A; MX1; HSPA2; Ifna15; HSPA1A
Influenza A
TNF; PIK3R5; IFNGR1; RNASEL; MAP2K4; IFNA1; VDAC1; CYCS; PRSS3; HLA-DOA
Herpes simplex infection
MHC2DEB; TLR3; SRSF7B; MAPK8B; MAVS; STAT2; EIF2AK1; HLA-B; C3A.1; HLA-C
Inflammatory bowel disease (IBD)
IL1B; TGFB1; IL12B; HLA-DRB4; HLA-DPB1; IL2RG; IL1A; IL13; NFATC1; IL4
Allograft rejection
IL10; HLA-DOA; HLA-DMA; TNF; H2-AB1; FASLG; HLA-DRB3; HLA-E; HLA-DRA; HLA-DRB5

Protein Function

IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cytokine activity
Related Protein IL12B; IL12A; CLCF1; CRLF1
Function contributes_to growth factor activity
Related Protein IL12A; IL12B
Function interleukin-12 beta subunit binding
Related Protein IL12A
Function interleukin-12 receptor binding
Related Protein JAK2; IL12BA; IL12B; IL12A
Function interleukin-27 binding
Related Protein IL12A
Function protein binding
Related Protein CDC26; UPF3B; SMARCD3; UBE2N; GATA1; ABCC2; RBM26; UACA; NTSR1; TBC1D2
Function protein heterodimerization activity
Related Protein IKZF1; HSPD1; EGFR; NOTCH4; BMP2B; HOMER2; GCA; NR4A1; UGT1A7; SMC2

Interacting Protein

IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.
IL12B; IL12RB1

IL12A Related Articles

Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).

IL12A Related Gene Family

IL