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IL12A

  • Official Full Name

    interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

  • Overview

    Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
  • Synonyms

    IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Feline
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Yeast
  • C
  • Fc
  • His
  • TwinStrep
  • Strep
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|Fc
  • His|S
  • His|T7
  • human|IgG1|Fc
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL12A-113H Active Recombinant Human IL12A HEK293 N/A
Human IL12A-27H Active Recombinant Human IL12A/IL12B protein Insect Cell N/A
Human IL12-21H Recombinant Human Interleukin-12 E.coli N/A
Human IL12A-26973TH Recombinant Human IL12A protein CHO N/A 525
Human IL12A-112H Recombinant Human IL12A HEK293 N/A
Human IL12A-309H Recombinant Human IL12A protein, Fc-tagged HEK293 human/IgG1/Fc Arg23-Ser219
Human IL12A-315H Recombinant Human IL12A, His tagged Human Cell His
Human IL12A-47H Recombinant Human IL12A Yeast N/A
Human IL12A-219H Recombinant Human IL12A Sf21 Insect Cell N/A
Human IL12A-29635TH Recombinant Human IL12A, His-tagged E.coli His
Human IL12A-42H Recombinant Human IL12A, His-tagged E.coli N/A
Human IL12A-165H Rcombinant Human IL12A, His-Fc-tagged Human Cell His/Fc
Human IL12A-132H Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged E.coli His
Human IL35-12H Recombinant Human IL12A/IL27B protein, Fc-tagged HEK293 Fc
Human IL12A-850H Recombinant Human IL12A protein, His & S-tagged E.coli His/S Arg23~Ser219 (Accession # P29459)
Human IL12A-587H Recombinant Human IL12A protein, His-tagged E.coli His The IL35 complex composed of IL27B subunit (Arg21~Lys229) and the mature form of human IL12A (Arg23~Ser219) linked by a polypeptide linker (GGGGS)3
Human IL12A-310H Recombinant Human IL12A Protein HEK293 N/A
Human IL12A & IL12B-357H Active Recombinant Human IL12A & IL12B protein HEK293 N/A Met1-Ser219 & Met1-Ser328
Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
Human IL12A-2435HCL Recombinant Human IL12A cell lysate Human Cell N/A
Human IL12A&IL27B-853HCL Recombinant Human IL12A&IL27B cell lysate Human Cell N/A
Human IL12A-062H Active Recombinant Human IL12 Protein E. coli
Human IL12A-139H Recombinant Active Human IL12A Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL12A-4327HG Active Recombinant Human IL12A protein CHO N/A
Human IL12A-129HG Active GMP Recombinant Human IL12A Protein Insect Cell N/A
Human IL12A-4300H Recombinant Human IL12A Protein (Met1-Ser219), C-His tagged Mammalian cells C-His Met1-Ser219
Human IL12A-75H Recombinant Human IL12A Protein Human Cell Arg23-Ser219&Ile23-Ser328
Human IL12A-25H Active Recombinant Human IL12 Protein, Animal Free Human cells
Human IL12A-0255H Recombinant Human IL12A protein, Fc-tagged HEK293 Fc Arg23-Ser219
Human IL12A-4301H Recombinant Human IL12A Protein (Met1-Lys229, Q14213 & Arg23-Ser219, P29459), C-Fc tagged Mammalian cells C-Fc Met1-Lys229 (Q14213) & Arg23-Ser219 (P29459)
Human IL12A-2577H Recombinant Human IL12A (Met1-Ser219) and IL12B (Met1-Ser328) Protein, C-Strep and C-His tagged Mammalian cells C-Strep and C-His Met1-Ser219
Human IL12A-176H Active Recombinant Human IL12A Protein (Arg23-Ser219), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg23-Ser219
Human IL12A-501H Recombinant Human IL12A Protein, Fc-tagged Fc 219
Human IL12A-4302H Recombinant Human IL12A Protein (Arg23-Ser219), C-Strep tagged Mammalian cells C-Strep Arg23-Ser219
Human IL12A-5833H Recombinant Human IL12A and EBI3 Protein (Arg23-Ser219, Arg21-Lys229), C-Fc tagged Mammalian cells C-Fc Arg23-Ser219, Arg21-Lys229
Mouse Il12a-01M Active Recombinant Mouse Il12a Protein, His-Tagged E.coli His
Mouse Il12a-226M Recombinant Mouse Interleukin 12a Sf21 Insect Cell N/A
Mouse Il12a-851M Recombinant Mouse Il12a protein, His & T7-tagged E.coli His/T7 Arg23~Ala215 (Accession # P43431)
Mouse Il12a-227M Recombinant Mouse Interleukin 12a, P40 Sf21 Insect Cell N/A
Mouse Il12a-209M Recombinant Murine Interleukin 12a CHO N/A
Mouse Il12a-228M Recombinant Mouse Interleukin 12a, P80 CHO N/A
Mouse Il12a-211M Recombinant Murine Interleukin 12a, P35-P40 CHO N/A
Mouse Il12a-210M Recombinant Murine Interleukin 12a, P35-P40 Sf9 Insect Cell N/A
Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
Mouse Il12a-6737M Recombinant Mouse Il12a Protein (Met23-Ser335, Arg23-Ala215) Mammalian cells Tag Free Met23-Ser335, Arg23-Ala215
Mouse Il12a-4053M Recombinant Mouse Il12a Protein (Arg23-Ala215), C-His tagged Mammalian cells C-His Arg23-Ala215
Mouse Il12a-140M Recombinant Active Mouse IL12A Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il12a-086M Active Recombinant Mouse Il12a Protein CHO
Mouse Il12a-6738M Recombinant Mouse Il12a Protein (Met1-Ala215), C-His and C-TwinStrep tagged Mammalian cells C-His and C-TwinStrep Met1-Ala215
Mouse Il12a-47M Active Recombinant Mouse Il12a Protein (Arg23-Ala215), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg23-Ala215
Mouse Il12a-6736M Recombinant Mouse Il12a Protein (Met1-Ala215, Met1-Ser335), C-His and C-TwinStrep tagged Mammalian cells C-His and C-TwinStrep Met1-Ala215, Met1-Ser335
Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
Rat IL12A-3025R Recombinant Rat IL12A Protein Mammalian Cell His
Rat Il12a-853R Recombinant Rat Il12a protein, His & T7-tagged E.coli His/T7 Arg23~Ser215 (Accession# Q9R103)
Rat IL12A-2680R Recombinant Rat IL12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL12A-2680R-B Recombinant Rat IL12A Protein Pre-coupled Magnetic Beads HEK293
Dog IL12A-1000D Recombinant Dog IL12A Protein, His-tagged E.coli N-His Leu41-Leu186
Cynomolgus Monkey IL12A-191C Recombinant Cynomolgus IL12A, Fc-tagged Human Cell Fc Met1-Ser219
Cynomolgus Monkey IL12A-190C Recombinant Cynomolgus IL12A Human Cell N/A Met1-Ser219 & Met1-Ser328
Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
Cynomolgus Monkey IL12A-001CCL Recombinant Cynomolgus IL12A cell lysate Human Cell N/A
Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A
Rhesus IL12A-9483R Recombinant Rhesus IL12A protein, hFc-tagged HEK293 hFc Met1-Ser219
Rhesus Macaque IL12A-2229R Recombinant Rhesus monkey IL12A Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL12A-2050R-B Recombinant Rhesus Macaque IL12A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL12A-2050R Recombinant Rhesus Macaque IL12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IL12A-1637Z Recombinant Zebrafish IL12A Mammalian Cell His
Pig IL12A-852P Recombinant Pig IL12A protein, His & T7-tagged E.coli His/T7 Leu26~Pro215 (Accession # NM_213993.1)
Chicken IL12A-7141C Recombinant Chicken IL12A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL12A Related Articles
  • IL12A Related Gene Family
  • IL12A Related Research Area
  • IL12A Related Signal Pathway

IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFRSF10B;GM13306;IL21;CCL11;BMP7B;BMPR2B;TNFSF13;AMH;TNFRSF9A
Toll-like receptor signaling pathwayMAPK12A;RAC1;STAT1A;PIK3R2;IFNA13;IRAK1;IRAK4;IL6;TMED7-TICAM2
RIG-I-like receptor signaling pathwayTMEM173;NFKBIA;NFKBIB;CASP8;OTUD5A;RNF207B;NLRX1;IFNA7;SIKE1
Jak-STAT signaling pathwayIL5RA;IL11RA2;CCND2A;IFNK;IL27RA;PTPN11A;MYCB;MCL1;JAK2A
Type I diabetes mellitusIL1A;CD80;HLA-DPA1;IL1B;INS1;GAD1;HLA-E;GZMB;H2-AA
PertussisIL1A;CALM4;NOS2;CXCL6;C1QA;ITGA5;CALML3;C4BPB;GNAI2
LegionellosisHSPA2;BNIP3;SAR1B;HSPD1;TLR4;NFKB2;CXCL2;HSPA1L;EEF1A1
LeishmaniasisFCGR3A;HLA-DRA;CR1;HLA-DQA1;HLA-DRB5;STAT1;NFKBIA;HLA-DMA;NCF1
Chagas disease (American trypanosomiasis)AKT1;TGFB3;IL10;CXCL8;IFNGR2;TICAM1;PIK3CD;PPP2CA;IKBKB
African trypanosomiasisIL12B;IL6;IDO2;FAS;PRKCB;GNAQ;APOA1;IFNG;HPR
MalariaTLR9;THBS2;TLR2;HBA1;TLR4;GYPB;GYPA;MYD88;SELE
ToxoplasmosisTGFB3;HLA-DRB1;BAD;PIK3CD;LAMB3;BIRC8;PIK3R5;HSPA6;PIK3CA
AmoebiasisTLR4;CTSG;ACTN1;IFNG;SERPINB13;VCL;COL4A3;NFKB1;GM-CSF
TuberculosisTNFRSF1A;CALM2;CASP9;ATP6V0A1;HLA-DQA1;BAD;NOS2;RELA;FCGR1A
MeaslesCCND1;MSN;IFNGR2;TNFRSF10C;IL12A;IFNA17;Fasl;IFNA10;IRAK4
Influenza AFAS;LOC100033925;PIK3CB;IFNA4;HSPA2;MAP2K3;RAF1;IFNA2;TLR3
Herpes simplex infectionHCFC2;PPP1CC;IFNG;GLTSCR2;SRSF9;CDC34A;IFNA16;HLA-DRB3;OAS1
Inflammatory bowel disease (IBD)FOXP3;IL13;SMAD3;IL1B;STAT3;IFNGR2;HLA-DQB1;IL18RAP;TNF
Allograft rejectionHLA-DRB1;Fasl;HLA-E;H2-AB1;HLA-B;HLA-DOA;HLA-A;MICA;IL5

IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.

Function Related Protein
contributes_to cytokine activityCLCF1;CRLF1;IL12B;IL12A
contributes_to growth factor activityIL12A;IL12B
interleukin-12 beta subunit binding
interleukin-12 receptor bindingIL12A;IL12BA;IL12B;JAK2
interleukin-27 binding
protein bindingGNAI2;SF3B4;CSE1L;RUNX1T1;STX1A;IL18R1;GFM1;PLD1;PHF21A
protein heterodimerization activityGTF2A2;TAF8;PPP3CB;DMBX1;SYT10;HIST1H2BH;HIST1H4A;MTTP;HIST1H2AL

IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.

IL12B; IL12RB1

Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).
IL
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How do mass spectrometry-based techniques reveal post-translational modifications on IL12A? 08/18/2022

Mass spectrometry identifies IL12A's post-translational modifications and their roles.

What strategies validate IL12A's role in immune response modulation using knockout models? 06/12/2022

Knockout models validate IL12A's roles in immune response modulation.

How do protein footprinting assays unveil IL12A's binding interfaces with receptor partners? 06/26/2021

Protein footprinting assays reveal IL12A's binding interfaces with receptors.

What experimental methods quantify IL12A's secretion kinetics and stability in cell culture? 12/17/2020

ELISA and stability assays quantify IL12A secretion and stability in culture.

Can you discuss the use of SPR in characterizing IL12A's interactions with antibodies and inhibitors? 10/25/2020

SPR characterizes IL12A's interactions with antibodies and inhibitors.

What cellular assays assess IL12A's ability to induce cytokine production in immune cells? 05/19/2019

Cellular assays gauge IL12A's cytokine induction in immune cells.

How does isothermal titration calorimetry provide insights into IL12A's binding affinity with receptors? 06/05/2018

Isothermal titration calorimetry measures IL12A's binding affinity with receptors.

What techniques evaluate the impact of IL12A genetic variants on protein structure and function? 03/08/2018

Structural biology techniques analyze IL12A genetic variant impacts.

Could you elaborate on the use of site-directed mutagenesis in probing IL12A's functional domains? 11/23/2017

Site-directed mutagenesis probes IL12A's functional domains and interactions.

How does in vivo bioluminescence imaging track IL12A expression dynamics in living organisms? 02/16/2017

Bioluminescence imaging tracks IL12A expression dynamics in vivo.

Customer Reviews (3)

Write a review
Reviews
01/14/2021

    Suitable for co-immunoprecipitation.

    12/21/2020

      Consistent in bioactivity.

      11/16/2020

        Good for receptor binding studies.

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