IL12A Protein, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

IL12A

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IL12A

Official Full Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Background Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
Synonyms IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Feline
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • His
    • S
    • T7
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL12A-4327HG Recombinant Human IL12A protein CHO N/A
    Mouse Il12a-086M Recombinant Mouse Il12a Protein CHO
    Human IL12-21H Recombinant Human Interleukin-12 E.coli N/A
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A
    Human IL12A&IL27B-853HCL Recombinant Human IL12A&IL27B cell lysate Human Cell N/A
    Human IL12A-112H Recombinant Human IL12A HEK293 N/A
    Human IL12A-113H Recombinant Human IL12A HEK293 N/A
    Human IL12A-129HG GMP Recombinant Human IL12A Protein Insect Cell N/A
    Human IL12A-132H Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged E.coli His
    Human IL12A-165H Rcombinant Human IL12A, His-Fc-tagged Human Cell His/Fc
    Human IL12A-219H Recombinant Human IL12A Sf21 Insect Cell N/A
    Human IL12A-2435HCL Recombinant Human IL12A cell lysate Human Cell N/A
    Human IL12A-26973TH Recombinant Human IL12A protein CHO N/A
    Human IL12A-27H Recombinant Human IL12A/IL12B protein Insect Cell N/A
    Human IL12A-29635TH Recombinant Human IL12A, His-tagged E.coli His
    Human IL12A-309H Recombinant Human IL12A protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL12A-310H Recombinant Human IL12A Protein HEK293 N/A
    Human IL12A-315H Recombinant Human IL12A, His tagged Human Cell His
    Human IL12A-42H Recombinant Human IL12A, His-tagged E.coli N/A
    Human IL12A-47H Recombinant Human IL12A Yeast N/A
    Human IL12A-587H Recombinant Human IL12A protein, His-tagged E.coli His
    Human IL12A-850H Recombinant Human IL12A protein, His & S-tagged E.coli His/S
    Human IL35-12H Recombinant Human IL12A/IL27B protein, Fc-tagged HEK293 Fc
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse Il12a-209M Recombinant Murine Interleukin 12a CHO N/A
    Mouse Il12a-210M Recombinant Murine Interleukin 12a, P35-P40 Sf9 Insect Cell N/A
    Mouse Il12a-211M Recombinant Murine Interleukin 12a, P35-P40 CHO N/A
    Mouse Il12a-226M Recombinant Mouse Interleukin 12a Sf21 Insect Cell N/A
    Mouse Il12a-227M Recombinant Mouse Interleukin 12a, P40 Sf21 Insect Cell N/A
    Mouse Il12a-228M Recombinant Mouse Interleukin 12a, P80 CHO N/A
    Mouse Il12a-851M Recombinant Mouse Il12a protein, His & T7-tagged E.coli His/T7
    Rat IL12A-3025R Recombinant Rat IL12A Protein Mammalian Cell His
    Rat Il12a-853R Recombinant Rat Il12a protein, His & T7-tagged E.coli His/T7
    Rat Il12b&Il12a-748R Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
    Cynomolgus Monkey IL12A-001CCL Recombinant Cynomolgus IL12A cell lysate Human Cell N/A
    Cynomolgus Monkey IL12A-190C Recombinant Cynomolgus IL12A Human Cell N/A
    Cynomolgus Monkey IL12A-191C Recombinant Cynomolgus IL12A, Fc-tagged Human Cell Fc
    Rhesus Macaque IL12A-2229R Recombinant Rhesus monkey IL12A Protein, His-tagged Mammalian Cell His
    Chicken IL12A-7141C Recombinant Chicken IL12A Mammalian Cell His
    Zebrafish IL12A-1637Z Recombinant Zebrafish IL12A Mammalian Cell His
    Pig IL12A-852P Recombinant Pig IL12A protein, His & T7-tagged E.coli His/T7
    Feline IL12B&IL12A-903F Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A

    IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TGFB2; CCL25B; BMPR1AB; CCR1; CSH; GM13304; Il4ra; CRFB4; TNFRSF19; IFNL3
    Toll-like receptor signaling pathway MAP2K6; TLR3; TLR5B; IFNAR2; TLR4BA; MAPK1; CXCL8B.3; MAPK14B; CCL4L2; RIPK1
    RIG-I-like receptor signaling pathway IRF3; IFNB1; MAPK8B; IFNK; MAPK12A; NFKBIB; RNF207B; IFNA1; IFNA7; ISG15
    Jak-STAT signaling pathway GM-CSF; IFNG; STAT4; SOCS1; STAT1A; IL21R.1; IL2RGA; FHL1; AOX2P; IFNA8
    Type I diabetes mellitus HLA-DOA; H2-AA; CD86; HLA-DOB; HLA-F; GZMB; HLA-DPB1; FASLG; INS; IL1B
    Pertussis NFKB1; ITGB2L; IL12A; C1QB; Il23a; Il12b; Casp3; IL6; ITGB2; C4BPB; GM5077
    Legionellosis RAB1A; HSPA8; ITGB2L; NLRC4; EEF1A2; EEF1A1; NFKB2; Itgam&Itgb2; TLR4; NAIP6
    Leishmaniasis HLA-DPB1; FCGR4; ITGB2; MAPK12; PTGS2; ITGB2L; MAPK13; STAT1; CYBA; H2-AA
    Chagas disease (American trypanosomiasis) GNAS; TLR2; CCL2; CXCL8; TRAF6; BDKRB2; MAPK9; IKBKG; PPP2R2C; PIK3CA
    African trypanosomiasis PLCB4; IDO2; HBB-B2; PLCB3; HBA1; HBA-A2; TNF; PRKCG; FAS; VCAM1
    Malaria TGFB3; CD40LG; DARC; LRP1; ITGAL; CD36; CD40; ICAM1; TGFB1; HGF
    Toxoplasmosis HSPA1L; NFKBIB; IRGM; HLA-DOB; PIK3R2; HLA-DPB1; LAMB2; CD40; CASP8; PIK3CD
    Amoebiasis CD1d1; IL1R1; AASS; PLCB3; SERPINB3C; SERPINB9; COL4A1; NOS2; LAMB4; LAMA4
    Tuberculosis TLR9; RFX5; TNF; CORO1A; HLA-DRB4; BAD; FCGR2B; RAF1; FCGR4; FCGR1A
    Measles PIK3CD; TP73; EIF2AK1; IL4; IL2RA; IFNA1; STAT5B; HSPA8; STAT1; PIK3CG
    Influenza A IL-8; IRF7; IL8L1; IFNA14; PABPN1L; CYCS; OAS1B; IVNS1ABP; NUP98; MAPK1
    Herpes simplex infection TAF4B; SRSF5B; ABCB3L1; SP100; PTPN11; IFN-a; TAP1; C3A.3; HLA-DQA2; TBPL1
    Inflammatory bowel disease (IBD) RELA; Il23a; TGFB3; IL12RB2; HLA-DOB; HLA-DRA; IFNG; Il4ra; H2-AB1; TGFB2
    Allograft rejection TNF; HLA-DQB1; HLA-DPA1; HLA-DRB3; HLA-G; Il2; CD40LG; IL5; HLA-DRB1; HLA-DQA1

    IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activity CRLF1; CLCF1; IL12A; IL12B
    contributes_to growth factor activity IL12A; IL12B
    interleukin-12 beta subunit binding IL12A
    interleukin-12 receptor binding JAK2; IL12A; IL12B; IL12BA
    interleukin-27 binding IL12A
    protein binding INADL; PDLIM7; TRAPPC6A; RHOG; DPYSL5; ALG13; GM5506; BAIAP2L1; FKBP5; FAM64A
    protein heterodimerization activity CENPW; PDSS1; XBP1; P4HB; TOP2A; UBA2; HEXB; Pdgfa&Pdgfb; HIST4H4; IKBKG

    IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.

    IL12B; IL12RB1

    Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
    Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).

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