il12a
Share
  • Official Full Name
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
  • Background
  • Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
  • Synonyms
  • IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
Cat.#:IL12A-4327HGTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL12A protein
+Inquiry
Cat.#:IL12A-310HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A Protein
+Inquiry
Cat.#:IL12A & IL12B-357HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B protein
+Inquiry
Cat.#:IL12A-113HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A
+Inquiry
Cat.#:IL12A-165HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRcombinant Human IL12A, His-Fc-tagged
+Inquiry
Cat.#:IL12A-26973THTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL12A
+Inquiry
Cat.#:IL12A-27HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IL12A/IL12B protein
+Inquiry
Cat.#:IL12A-29635THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A, His-tagged
+Inquiry
Cat.#:IL12A-309HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A, Fc tagged
+Inquiry
Cat.#:IL12A-315HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A, His tagged
+Inquiry
Cat.#:IL12A-47HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL12A
+Inquiry
Cat.#:IL12A-587HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A protein, His-tagged
+Inquiry
Cat.#:IL12A-850HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A protein, His & S-tagged
+Inquiry
Cat.#:IL35-12HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A/IL27B protein, Fc-tagged
+Inquiry
Cat.#:Il12a-228MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a, P80
+Inquiry
Cat.#:Il12a-851MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12a protein, His & T7-tagged
+Inquiry
Cat.#:IL12A-3025RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL12A Protein
+Inquiry
Cat.#:Il12a-853RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il12a protein, His & T7-tagged
+Inquiry
Cat.#:Il12b&Il12a-748RTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Rat
Product nameRecombinant Rat Il12b&Il12a
+Inquiry
Cat.#:IL12A-190CTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A
+Inquiry
Cat.#:IL12A-191CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A, Fc-tagged
+Inquiry
Cat.#:IL12A-2229RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL12A Protein, His-tagged
+Inquiry
Cat.#:IL12A-7141CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL12A
+Inquiry
Cat.#:IL12A-1637ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL12A
+Inquiry
Cat.#:IL12A-852PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL12A protein, His & T7-tagged
+Inquiry
Cat.#:IL12B&IL12A-903FTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Feline
Product nameRecombinant Feline IL12B&IL12A
+Inquiry
Cat.#:IL12-21HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-12
+Inquiry
Cat.#:IL12A-112HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A
+Inquiry
Cat.#:IL12A-219HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IL12A
+Inquiry
Cat.#:IL12A-42HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12A, His-tagged
+Inquiry
Cat.#:Il12a-209MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a
+Inquiry
Cat.#:Il12a-210MTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a, P35-P40
+Inquiry
Cat.#:Il12a-211MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Murine Interleukin 12a, P35-P40
+Inquiry
Cat.#:Il12a-226MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a
+Inquiry
Cat.#:Il12a-227MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12a, P40
+Inquiry
Cat.#:IL12A & IL12B-1908HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A&IL27B-853HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A&IL27B cell lysate
+Inquiry
Cat.#:IL12A-2435HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A cell lysate
+Inquiry
Cat.#:IL12A & IL12B-1779MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A & IL12B-1780MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A & IL12B-1781MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A & IL12B-1782MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A & IL12B-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A & IL12B cell lysate
+Inquiry
Cat.#:IL12A-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A cell lysate
+Inquiry
Cat.#:IL12A-129HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human IL12A Protein
+Inquiry

Involved Pathway

IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNA2; IFNAR1; BMP2; ACVR1; CCL15; CSF3; PRLR; EPO; TNFRSF11B; CNTF
Toll-like receptor signaling pathway
IRAK1; IFNPHI1; IFNA8; STAT1; IFNAR1; IFNA14; IFNA4; TLR4BB; NFKBIAB; TLR2
RIG-I-like receptor signaling pathway
FADD; TRAF2; IL8L2; IRF3; IFIH1; MAPK14B; RELA; TNF; SIKE1; NFKB1
Jak-STAT signaling pathway
CCND2; IFNGR2; PTPN11B; IFNA13; IL20RA; AOX3; MPL; STAT4; EP300; SOCS1
Type I diabetes mellitus
IL1A; IL1B; H2-Q10; HLA-DQA2; HLA-E; IFNG; HLA-DQA1; IL12B; HLA-DOB; Fasl
Pertussis
Hc; CALM3; MAPK13; ITGB2L; NLRP3; GNAI1; TRAF6; CALML3; CALML5; Casp3
Legionellosis
ITGAM; RELA; HSPA1A; ITGB2L; HSPA6; ITGB2; SAR1B; MYD88; RAB1B; BCL2L13
Leishmaniasis
MAPK1; H2-AB1; NCF1; MARCKSL1; IRAK1; FCGR1A; TAB2; TRAF6; HLA-DPB1; HLA-DMA
Chagas disease (American trypanosomiasis)
NFKB1; PIK3CB; NOS2; AKT1; CD3D; IKBKG; CXCL8; MAPK1; MAPK12; GNA15
African trypanosomiasis
IL1B2; SELE; HBA-A2; FAS; PLCB4; PLCB1; FASLG; VCAM1; IL6; THOP1
Malaria
SDC2; IL6; THBS4; HBB-B2; HBA1; CD40; IL-8; KLRB1; GYPA; GYPC
Toxoplasmosis
PIK3R5; LAMA2; HLA-DRB4; IFNGR2; MAPK12; MAPK3; MAPK10; CYCS; NOS2; STAT3
Amoebiasis
LAMA2; PLCB3; Casp3; CXCL1; COL4A5; HSPB1; IL1R1; C8B; PLCB1; COL24A1
Tuberculosis
CORO1A; CD74; MAPK9; PPP3CC; SYK; IL12B; IFNA8; MYD88; HLA-DQA1; MAPK1
Measles
SLAMF1; IFNA5; SH2D1A; DOK1; CBLB; OAS2; IFNA6; TAB2; IL13; IL2RA
Influenza A
DNAJB1; IFNA13; MAPK3; IFNA2; STAT1; HLA-DPA1; MAPK12; HLA-DRB1; Ifna15; CASP1
Herpes simplex infection
OAS3; Fasl; USP7; PVRL1; EIF2AK2; SRSF7A; SRSF9; HLA-DRB4; HLA-DPA1; IFNAR1
Inflammatory bowel disease (IBD)
IL13; IL1A; TNF; IFNG; HLA-DRB1; TLR2; STAT4; HLA-DMA; TGFB1; IL4
Allograft rejection
HLA-C; CD80; IL10; H2-AB1; HLA-DMB; HLA-DMA; HLA-F; CD40; HLA-E; HLA-B

Protein Function

IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cytokine activity
Related Protein CLCF1; IL12B; IL12A; CRLF1
Function contributes_to growth factor activity
Related Protein IL12A; IL12B
Function interleukin-12 beta subunit binding
Related Protein IL12A
Function interleukin-12 receptor binding
Related Protein IL12BA; IL12A; JAK2; IL12B
Function interleukin-27 binding
Related Protein IL12A
Function protein binding
Related Protein TFAP4; STK38L; PKD2L1; KIAA0101; ARHGEF15; C1D; HNRPLL; INTS9; EPHB1; PYGO2
Function protein heterodimerization activity
Related Protein HIST1H2AB; NAE1; GRIN1; TAF9B; ADIPOR2; SUPT4H1; MAFA; ADIPOR1; MYOG; SUPT3H

Interacting Protein

IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.
IL12B; IL12RB1

IL12A Related Articles

Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).

IL12A Related Gene Family

IL