il5
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  • Official Full Name
  • interleukin 5
  • Background
  • This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
  • Synonyms
  • EDF; TRF; IL-5; B Cell Differentiation Factor I; B-cell differentiation factor I; Colony stimulating factor; Colony Stimulating Factor Eosinophil; Eosinophil; Eosinophil Differentiation Factor; IL 5; IL5; IL5_HUMAN; Interleukin 5 (colony stimulating factor, eosinophil); Interleukin 5; Interleukin-5; Interleukin5; T Cell Replacing Factor; T-cell replacing factor;
Cat.#:IL5-456CTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Canine
Product nameRecombinant Canine IL5 Protein, His-tagged
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Cat.#:IL5-998CTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Cynomolgus
Product nameRecombinant Cynomolgus IL5 Protein (Met1-Ser134), His-tagged
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Cat.#:IL5-5178HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL5 Protein, GST-tagged
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Cat.#:Il5-2096MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il5 Protein
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Cat.#:Il5-2097MTag:
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Il5 Protein
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Cat.#:Il5-2095RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il5 Protein
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Cat.#:IL5-2177CTag:His
Source (Host):Insect cellSpecies:Canine
Product nameRecombinant Canine IL5 Protein, His-tagged
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Cat.#:IL5-4361RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit IL5 Protein
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Cat.#:IL5-4331FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline IL5 Protein
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Cat.#:IL5-125HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5
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Cat.#:IL5-126HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5 protein, His-tagged
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Cat.#:IL5-144HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5 protein
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Cat.#:IL5-185HTag:FC/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5, His tagged
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Cat.#:IL5-214HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IL5
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Cat.#:IL5-269HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL5, StrepII-tagged
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Cat.#:IL5-27607THTag:His
Source (Host):Species:Human
Product nameRecombinant Human IL5, His-tagged
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Cat.#:IL5-312HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5
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Cat.#:IL5-502HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL5 protein, His-tagged
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Cat.#:IL5-61HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5
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Cat.#:IL5-651HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL5 protein, His & T7-tagged
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Cat.#:IL5-8864HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human IL5,His-tagged
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Cat.#:IL5-99HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL5
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Cat.#:Il5-121MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il5
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Cat.#:Il5-206MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Interleukin 5
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Cat.#:Il5-224MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Interleukin 5
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Cat.#:Il5-755MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Il5, His tagged
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Cat.#:Il5-97RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 5
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Cat.#:IL5-2253RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL5 Protein, His-tagged
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Cat.#:IL5-653RTag:His/GST
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey IL5 protein, His & GST-tagged
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Cat.#:IL5-963RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL5 protein
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Cat.#:IL5-27CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-5
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Cat.#:IL5-650DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL5 protein, His & T7-tagged
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Cat.#:IL5-1735CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL5
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Cat.#:IL5-1048FTag:His
Source (Host):NSO CellsSpecies:Feline
Product nameRecombinant Feline IL5 Protein, His-tagged
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Cat.#:IL5-652PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL5 protein, His & T7-tagged
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Cat.#:IL5-901ETag:His
Source (Host):NSO CellsSpecies:Equine
Product nameRecombinant Equine IL5 Protein, His-tagged
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Cat.#:IL5-528HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 5 (Colony-Stimulating Factor, Eosinophil)
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Cat.#:IL5-412MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-5
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Cat.#:IL5-257ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 5 (Colony-Stimulating Factor, Eosinophil)
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Cat.#:IL5-1240HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 5
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Cat.#:IL5-496MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse IL5 cell lysate
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Cat.#:IL5-456CCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Canine
Product nameRecombinant Canine IL5 cell lysate
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Cat.#:IL5-4320HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL5 protein
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Cat.#:IL5-103HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-5(rDNA derived) Reference standard
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Involved Pathway

Il5 involved in several pathways and played different roles in them. We selected most pathways Il5 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
GHRA; NT5C3; VEGFA; IL-8; HGF; TGFBR1; PRL; GM-CSF; CCL7; LTA
Jak-STAT signaling pathway
RNF207B; PIAS4B; GH2; PIK3CB; GH1; IFNA8; IL5RA; IFNA7; IL12RB2; STAT1A
Hematopoietic cell lineage
ITGA2B; HLA-DRB4; IL9R; IL1A; TFRC; CD37; CD5; CD1E; CD1d1; KITLG
T cell receptor signaling pathway
IFNG; IL4; CD3D; MAPK11; PPP3CA; PIK3CA; AKT2; PAK1; KRAS; MAPK12
Fc epsilon RI signaling pathway
RAF1; MAP2K4; PIK3R1; MAP2K7; PLCG2; FCER1A; PIK3R2; SOS1; MS4A2; MAPK1
Intestinal i
HLA-DQB1; BLB2; TGFB1A; CCL28; HLA-DOA; HLA-DPB1; ICOSLG; MHC2DEB; TNFRSF13B; LTBR
ne network for IgA production
MHC2DAB; CCL25B; CXCL12; ITGB7; H2-AB1; HLA-DQB1; AICDA; ICOS; ITGA4; HLA-DPA1
Asthma
HLA-DQB1; HLA-DRB3; H2-AB1; IL10; HLA-DPA1; MS4A2; EPX; HLA-DMA; FCER1A; CD40
Autoi
HLA-DRB1; HLA-DQA2; IFNA7; IFNA4; HLA-DMB; HLA-DRB4; HLA-A; IFNA21; IL4; IFNA14
ne thyroid disease
HLA-DQB1; FASLG; HLA-DRB3; IFNA16; CD40LG; Fasl; IFNA7; HLA-DQA1; HLA-DRB5; IFNA2
Inflammatory bowel disease (IBD)
HLA-DRB5; HLA-DQB1; IL12RB2; SMAD2; HLA-DPB1; IL6; H2-AB1; IL1B; TNF; HLA-DQA2
Allograft rejection
IL10; HLA-DPA1; HLA-DQB1; IL4; HLA-E; HLA-DOB; HLA-DMA; HLA-C; HLA-DRB3; CD28

Protein Function

Il5 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-5 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il5 itself. We selected most functions Il5 had, and list some proteins which have the same functions with Il5. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Ccl12; CSF1; CMTM2B; BMP1; IL4; SLURP1; IFNA6; IFNG1-1; IFNG1-2; CCL20B
Function growth factor activity
Related Protein FGF20; FGF2; CSF1A; GFER; BMP7A; GDF6; NRG1; REG1A; BMP7B; FGF10B
Function interleukin-5 receptor binding
Related Protein IL5; SDCBP
Function protein binding
Related Protein RFC3; PDS5A; MGST1; YWHAG; NCK1; RNF126; HNF1B; AKAP5; HSF1; DSCC1

Interacting Protein

Il5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il5.
CSF2RB; IL5RA

Il5 Related Articles

Hemmerle, T; Zgraggen, S; et al. Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation. JOURNAL OF DERMATOLOGICAL SCIENCE 76:96-103(2014).
Hou, S; Landego, I; et al. Follicular dendritic cell secreted protein FDC-SP controls IgA production. MUCOSAL IMMUNOLOGY 7:948-957(2014).

Il5 Related Gene Family

IL