stat3
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  • Official Full Name
  • Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
  • Background
  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
  • Synonyms
  • STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
Cat.#:STAT3-001HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-138HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-131HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-1496HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-2172HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-2174HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2175HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2176HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-281HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-282HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-29822THTag:His
Source (Host):Species:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-29823THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-316HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-335HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-336HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-337HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-39228HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-73HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Signal Transducer And Activator Of Transcription 3
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Cat.#:STAT3-16109MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAT3 Protein
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Cat.#:Stat3-8593MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat3 protein, His-tagged
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Cat.#:STAT3-5778RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STAT3 Protein
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Cat.#:STAT3-2620CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STAT3
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Cat.#:STAT3-9038ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT3
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Cat.#:STAT3-1735CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle STAT3 protein, His-tagged
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Cat.#:STAT3-1417HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Cat.#:STAT3-1418HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Involved Pathway

STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
GNGT2; GSK3A; GRK7; SHC3; CCL3; NFKBIB; CCL7; GRB2; PTK2B; CRK
HIF- signaling pathway
NOX1; IL6R; NOS3; EP300; IFNGR1; GAPDH; PIK3CB; TCEB1; SERPINE1; PDHB
FoxO signaling pathway
FOXO1B; PTENA; PLK1; BNIP3; GABARAP; RAG1; CDKN2D; CCND2A; INS1; HOMER1
Signaling pathways regulating pluripotency of stem cells
BMPR1B; ONECUT1; HOXB1; MAPK13; WNT9A; IGF1R; SMAD1; FZD5; REST; PCGF6
Jak-STAT signaling pathway
IRX1; CSH1; MTOR; PIAS4; IL22RA1; PRL2; IFNGR2; RNF207B; BCL2; SOCS1A
Prolactin signaling pathway
NEK3; MAPK12; ELF5; SHC4; STAT1; LHCGR; SOCS1; FOS; SOCS2; GRB2
Adipocytokine signaling pathway
PCK2; STK11; ACSL4; POMCA; ACSBG1; PTPN11; IRS4; JAK2B; PRKAA1; ACSL3
Insulin resistance
SLC2A1A; PTPN11A; SLC2A1; FOXO1; PRKCZ; FOXO1B; MAPK8; OGT.1; SLC27A1B; CREB3L1
Toxoplasmosis
HLA-DOA; MAP2K3; HLA-DPA1; LAMC1; LAMA5; IFNGR2; PIK3CA; HLA-DMB; TGFB2; LAMA3
Hepatitis C
IFNA17; HRAS; CLDN6; PPARA; STAT2; DDX58; EIF2AK3; MAPK13; TRP53; IRF3
Hepatitis B
NFKB1; IFNB1; IFNA5; VDAC3; BAD; APAF1; PRKCA; PIK3R5; IFNA16; TLR4
Measles
TNFRSF10D; IL12B; CD3E; CD28; IFNA21; HSPA8; CCND1; IRF7; IFNA2; PIK3R5
Epstein-Barr virus infection
HLA-DQA1; POLR3K; IL10RB; HSPA1B; NFKBIE; GTF2E2; H2-Q10; GSK3B; PIK3R5; VIM
Pathways in cancer
PLCB3; FGF12; Fasl; GNB4; TRP53; GNGT1; ITGA6; CCNA1; FGF10; WNT2B
Viral carcinogenesis
HPN; HIST2H2BE; GRB2; SP100; CCNA2; CCND1; HIST1H4N; ACTN1; NFKB2; GTF2B
Proteoglycans in cancer
NUDT16L1; RAF1; SMAD2; TFAP4; CD44; NRAS; MMP9; MAPK13; KRAS; ITPR1
MicroRNAs in cancer
ITGA5; PLAU; MAPK1; PDCD4; DNMT3B; MARCKS; DICER1; KRAS; PIK3R2; STAT3
Pancreatic cancer
MAP2K1; PIK3CA; STAT1; AKT1; ARAF; TGFB3; SMAD3; MAPK9; TGFA; BAD
Acute myeloid leukemia
NRAS; MAPK3; PIK3R2; PIK3CB; CCND1; PIK3R3; PIM1; RUNX1; PIK3CA; LEF1
Inflammatory bowel disease (IBD)
TGFB1; IL1B; TLR5; IL12A; IL12RB2; IL2RG; IL18; HLA-DOA; TGFB2; IFNGR1

Protein Function

STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.
Function
Related Protein
Function CCR5 chemokine receptor binding
Related Protein JAK1; STAT3; CCL5; CNIH4; CCL4; CCL3
Function DNA binding
Related Protein ZBTB17; NR1H2; BANF2; AHRR; HMGA1A; POLR2L; HOXB1A; NKX2-6; EBF3A; ZNF37A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein EGR2; ISL1; HHEX; HOXA10; RBPJB; PER1; MZF1; CEBPZ; TBX15; SREBF1
Function RNA polymerase II repressing transcription factor binding
Related Protein BBS10; MKKS; MTA2; TCF7L2; PPARA; HDAC1; STAT3; GTF2A2; GATA6; RBPJ
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein PPARAB; NR4A2B; NR2F6A; PPARD; NR5A5; NR1I3; NR5A2; NR1H2; HNF4G; ESR2
Function glucocorticoid receptor binding
Related Protein FKBP4; NRIP1; STAT5B; YWHAH; GRIP1; ETS2; NR4A2; EP300; STAT3; CEBPB
Function protein binding
Related Protein SHARPIN; TMF1; IFI35; SPHK1; ERAP1; PTCRA; ABCD1; KIAA1199; KLHL35; LGR6
Function protein dimerization activity
Related Protein HER1; PRDX5; FAP; DBI; HER4.3; ATOH1A; SRFA; EPAS1B; ASCL4; NCOA1
Function protein kinase binding
Related Protein SHC3; CDC25B; RHEB; MAVS; RNF138; ERRFI1; IKBKB; TRAF6; MSH2; MAG
Function protein phosphatase binding
Related Protein PPME1; JUPA; ROS1; PPP1R3C; VCP; DLG3; MAPK14; JUP; GNB2L1; FGF19
Function signal transducer activity
Related Protein TAAR12A; OPN1LW2; ACKR3B; GNG10; OLFR147; OLFR688; OLFR186; TICAM1; GNAIA; TAS2R136
Function transcription factor activity, sequence-specific DNA binding
Related Protein NR5A2; BCL3; MYOG; ELF3; ETS2; TGIF2; FOXA1; KDM5B; HES6; FOXJ1B
Function transcription factor binding
Related Protein NAB1; CSNK2B; MYBBP1A; PPID; DIP2C; KAT2A; HEY2; Trl; AGTR2; ETS1
Function transcription regulatory region DNA binding
Related Protein TFE3; SALL1A; NKX2; TAL1; AIRE; NKX3-1; ARID5B; TP53; WNT5A; SMAD3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein KLF5; ZSCAN21; KCNA3; ALS2CR8; MZF1; ETV2; MTF1; MITFB; TFAM; MEOX1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MYOG; DMRT1; NR1I3; OVOL2; PPARG; MYF6; BARHL1A; GRHL3; SOHLH2; MAFBB

Interacting Protein

STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.
EGFR; ERBB2

STAT3 Related Articles

Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).

STAT3 Related Gene Family

TGF Cytokines