STAT3
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Official Full Name
Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
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Overview
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. -
Synonyms
STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Human, Mouse, Rat, Bos taurus; Cattle
- Mouse
- Rat
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- Human cells
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Insect cells
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- DYKDDDDK
- Flag
- GST
- His (Fc)
- Avi
- His|MBP
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- STAT3 Related Articles
- STAT3 Related Gene Family
- STAT3 Related Research Area
- STAT3 Related Signal Pathway
STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chemokine signaling pathway | Ccl9;PRKCZ;IL-8;CCR10;PAK1;CRK;VAV1;GNG13;Ccl12 |
HIF- signaling pathway | RPS6KB1;IGF1;INS;CAMK2A;TF;IFNGR1;VEGFA;RBX1;ARNT |
FoxO signaling pathway | BCL6;IRS2;BNIP3;PRKAB1;CCNB2;MAPK13;SLC2A4;FBXO32;ARAF |
Signaling pathways regulating pluripotency of stem cells | ZFHX3;SKIL;NANOG;WNT5B;ID3;PCGF2;NEUROG1;ESX1;REST |
Jak-STAT signaling pathway | IFNA4;IL6ST;IL22RA1;IFNG1-2;CCND2;PIK3R3;M17;Gh;Il6ra |
Prolactin signaling pathway | SOCS6;MAPK13;INS;FOS;SOCS5;GRB2;STAT1;SOCS3;CCND1 |
Adipocytokine signaling pathway | TNFRSF1B;CAMKK1;SOCS3;PRKAB1;RXRB;NFKBIA;RXRGB;MAPK8;IRS2 |
Insulin resistance | RPS6KAL;IRS2;PYGM;PRKAG3B;G6PC3;GFPT2;PRKAG2;MAPK8;PRKCBB |
Toxoplasmosis | GNAI1;CASP8;TLR2;HLA-DQA1;HLA-DMB;GNAI2;HLA-DRA;MAPK10;IL12B |
Hepatitis C | NFKBIA;CLDN5;PPP2R1A;IFNA7;CLDN22;IFN-a;EIF2AK4;BAD;IL-8 |
Hepatitis B | KRAS;PTEN;CCNA1;PIK3CB;IKBKE;YWHAB;CCNA2;STAT3;Fasl |
Measles | DOK1;PIK3CB;TACR1;IFNG;EIF3H;PIK3R5;IFNA16;TNFSF10;TLR4 |
Epstein-Barr virus infection | POLR2A;PSMD6;PSMD13;TRAF3;AKT1;GTF2E1;PSMC1;RAN;PRKACG |
Pathways in cancer | LAMC2;RB1;FZD2;GNG12;NKX3;WNT5A;MMP1;KITLG;CCNE1 |
Viral carcinogenesis | UBR4;MAPK3;HIST1H2BA;BAD;RBL1;HIST1H4C;PIK3R5;GTF2A2;SKP2 |
Proteoglycans in cancer | SMAD2;FLNA;MMP2;PIK3CG;CAMK2D;NUDT16L1;BRAF;PRKCB;PLCE1 |
MicroRNAs in cancer | MAP2K2;GLS2;ABCB1;CYP24A1;CDCA5;PRKCG;TP53;SLC7A1;VEGFA |
Pancreatic cancer | IKBKG;PIK3CA;PLD1;RB1;ERBB2;PIK3CB;KRAS;RAD51;ARHGEF6 |
Acute myeloid leukemia | MTOR;CHUK;AKT2;CCND1;STAT5B;PIK3R2;NRAS;RARA;PIK3CA |
Inflammatory bowel disease (IBD) | IL17F;TLR5;IL23;IL4R;HLA-DRB4;HLA-DMB;TLR2;RORC;RORA |
STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.
Function | Related Protein |
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CCR5 chemokine receptor binding | CCL3;CNIH4;CCL5;STAT3;JAK1;CCL4 |
DNA binding | OLIG2;CREBZF;PPARAA;ZNF485;HIST2H3C;RC3H2;DDX41;SYCP3;PAX6A |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF502;TP73;MYBL2;PRDM5;HIST2H3A;RUNX2;ZNF695;ATF3;OTX1 |
RNA polymerase II repressing transcription factor binding | GSC;BBS7;TCF7L2;MTA2;HDAC2;PPARA;RBBP8;RBPJ;TBX5A |
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR6A1;NR1I2;PTGER3;NR5A1B;NR2E3;PPARAA;RORCB;NR5A1A;NR4A2A |
glucocorticoid receptor binding | EP300;STAT3;STAT5B;YWHAH;FKBP4;GRIP1;NR4A2;ETS2;CEBPB |
protein binding | MICALL2;APOBEC3C;TNFRSF11A;PITPNM3;HOXB6;RRS1;CALML3;SMC4;ORM1 |
protein dimerization activity | AHRRB;BETA3;STAT3;ANO7;SREBF2;HPSE;POLR2C;HER7;ATOH1 |
protein kinase binding | PKD1;FBXO7;HDAC7;IFNAR2;ACTA2;GYS1;Fert2;SNAP91;RACGAP1 |
protein phosphatase binding | CDC27;JUPA;PPP6R3;HSF4;KCNN4;VCP;Itga10&Itgb1;AP3B1;MAP2K7 |
signal transducer activity | OPN1LW2;CELSR1;GNAZ;YARS;TAAR7B;OLFR508;STAT3;GNA15;APLNRB |
transcription factor activity, sequence-specific DNA binding | FOXC1B;SIN3A;ATF1;RORB;ATF5;HOXC5;RERE;NR2F1B;SP1 |
transcription factor binding | TFAP2A;Ar;PBX1;NLK;NR0B1;NFKBIA;E2F4;PIAS2;SOST |
transcription regulatory region DNA binding | NCOR1;POU5F1;FOXH1;ATF4;TAF9;MZF1;XRCC6;GFI1;SIX1 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | EHF;CEBPB;SOX11;GCM1;BCL11B;FOS;EBF4;CARF;ETV6 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFGB;MYF6;ALX4;PPARG;MAFK;ELF5;BARX1;PKNOX1;MAF |
STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.
EGFR; ERBB2
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
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