stat3
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  • Official Full Name
  • Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
  • Background
  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
  • Synonyms
  • STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
Cat.#:STAT3-001HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-138HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-31HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-131HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-1496HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-2172HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-2174HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2175HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2176HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-281HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-282HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-29822THTag:His
Source (Host):Species:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-29823THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-316HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-335HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-336HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-337HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-39228HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-73HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Signal Transducer And Activator Of Transcription 3
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Cat.#:STAT3-16109MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAT3 Protein
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Cat.#:Stat3-8593MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat3 protein, His-tagged
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Cat.#:STAT3-5778RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STAT3 Protein
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Cat.#:STAT3-2620CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STAT3
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Cat.#:STAT3-9038ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT3
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Cat.#:STAT3-1735CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle STAT3 protein, His-tagged
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Cat.#:STAT3-1417HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Cat.#:STAT3-1418HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Involved Pathway

STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
CCL25; AKT2; CCL11; NFKB1; STAT5B; NCF1; GNB3; RAF1; CCL3; CCL4L1
HIF- signaling pathway
PLCG2; PIK3CG; IGF1R; PIK3R1; PDHB; PDK1; RELA; SLC2A1; HKDC1; Il6ra
FoxO signaling pathway
GRB2B; HOMER2; FOXO3B; MAPK12B; INS2; IRS2; CDKN1BB; IGF1; GADD45AA; PDPK1
Signaling pathways regulating pluripotency of stem cells
FZD3; INHBE; NRAS; WNT3; FGFR1; ONECUT1; FGFR2; MYF5; IGF1; ACVR1C
Jak-STAT signaling pathway
IFNA7; IFNG; IL12A; IL5; IFNK; CSH2; SOCS7; IL22RA2; PRL; SOCS6
Prolactin signaling pathway
NRAS; SOCS1; SIRPA; PIK3R1; ESR2; SLC2A2; SHC4; SOCS5; PIK3CG; PRP2
Adipocytokine signaling pathway
LEPR; ACSL5; MAPK8; PRKAA2; LEP; PRKAG3B; IRS2; ACSBG1; TRADD; ACSBG2
Insulin resistance
PIK3R3A; PPP1R3D; RPS6KA3A; PTPN11; RPS6KA1; G6PCA.1; SLC27A5; INSR; SOCS3; AKT1
Toxoplasmosis
IFNGR1; IL10RA; Toxoplasma Gondii Major Surface Antigen P30; NOS2; HLA-DQB1; XIAP; NFKB1; TGFB3; TLR4; GNAO1
Hepatitis C
MAPK10; IL-8; CLDN17; KRAS; MAPK13; PIK3CA; RIPK1; EIF2AK1; TP53; TRAF2
Hepatitis B
EP300; MAP2K2; TLR3; HBXIP; NFKBIA; BAX; BIRC5; MMP9; MAP2K4; CASP12
Measles
PIK3R3; IKBKE; CD209A; IFNA14; IRF7; CD209B; TNFRSF10A; RAB9A; CCNE2; TP53
Epstein-Barr virus infection
PSMC2; IRAK1; HLA-DRB4; GTF2E1; HDAC1; SYK; MAP2K3; SPN; PSMC3; HLA-F
Pathways in cancer
TFG; GNG11; FGFR2; AKT1; STK4; TGFA; FGF16; MECOM; EGLN1; PTK2
Viral carcinogenesis
HIST2H4A; HIST1H4E; HIST1H4L; YWHAZ; VDAC3; GTF2A1; BAK1; STAT3; GTF2E1; CREB5
Proteoglycans in cancer
ROCK2; ITPR3; WNT2B; PIK3R5; PIK3R3; PPP1CB; AKT1; Ctsl; PTCH1; TFAP4
MicroRNAs in cancer
PRKCA; SPRY2; PTEN; HNRNPK; CCNG1; NRAS; PDGFRB; MAP2K1; NOTCH3; CCNE2
Pancreatic cancer
RAC2; TGFBR2; TGFBR1; ARAF; ERBB2; SMAD3; MAP2K1; TGFB1; STAT1; MAPK3
Acute myeloid leukemia
GRB2; TCF7; CHUK; STAT5A; KRAS; TCF7L2; PML; AKT1; RUNX1T1; AKT2
Inflammatory bowel disease (IBD)
HLA-DRA; FOXP3; TLR2; IL22; TLR5; IFNGR2; IL21R; IL4R; TGFB3; NFKB1

Protein Function

STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.
Function
Related Protein
Function CCR5 chemokine receptor binding
Related Protein STAT3; JAK1; CCL3; CCL5; CCL4; CNIH4
Function DNA binding
Related Protein MAFBB; ZNF652; HIVEP2; KDM5B; PPARD; RREB1; ZFP39; TOX3; INSM1A; CMYB
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RFX3; NR1D1; CC2D1A; RELA; FLI1; RFX5; IFI16; NEUROD1; NFAT5; CDX4
Function RNA polymerase II repressing transcription factor binding
Related Protein CHD4; SP1; BBS1; RBBP8; RBPJ; GATA6; STAT3; TBX5A; SIN3A; PROL1
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RORC; NR2F6B; NR2F1B; RORAB; NR2F1A; PPARDB; PPARG; RORCA; NR4A2B; NR1H3
Function glucocorticoid receptor binding
Related Protein GRIP1; YWHAH; FKBP4; NRIP1; STAT3; ETS2; EP300; STAT5B; NR4A2; CEBPB
Function protein binding
Related Protein KRT17; POU4F1; EP300; BAG5; CCNK; RSPH1; MRPL1; NUFIP2; CAPG; TANK
Function protein dimerization activity
Related Protein HES3; PRDX5; HER12; HEY1; MXD3; MESPBA; NCOA1; MXD1; HPS1; HER4.3
Function protein kinase binding
Related Protein TP53; CCNL1B; RNF138; YWHAZ; VDAC1; MEF2A; MAPKAP1; ADRA2A; CDKN2A; SOCS1
Function protein phosphatase binding
Related Protein PPP1R3G; ANAPC5; DLG3; VCAN; PPP6R1; TRAF2; VRK3; SKAP1; DRD1A; RPA3
Function signal transducer activity
Related Protein LPAR2B; TAS2R118; OLFR508; NDFIP2; OLFR78; OLFR486; OLFR151; OMPB; VMN1R44; CBLC
Function transcription factor activity, sequence-specific DNA binding
Related Protein NR2F6B; HOXB4; TBX5; TCF3A; ZNF287; ATF5; HMGA1; SMAD3; MAFG; FOXD1L
Function transcription factor binding
Related Protein PPP1R13BA; DOT1L; LCOR; HES2; SOX17; KLF5; NKX2-5; APBB2; ARRB1; TAF7L
Function transcription regulatory region DNA binding
Related Protein SMAD3; ZNF174; ZNF821; MTERFD1; CTCF; TBL1X; FOXI1; JUN; HDAC1; TBL1XR1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MAFA; KLF4; FOXL2; STAT3; NDN; PAX5; SP1; MYOG; JUN; HMGA2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MYF5; GRHL2; NHLH1; MAFBA; LEF1; NR1I3; GABPA; SRF; PAX9; MAFBB

Interacting Protein

STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.
EGFR; ERBB2

STAT3 Related Articles

Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).

STAT3 Related Gene Family

TGF Cytokines