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Active Recombinant Mouse Fgf2 Protein

Cat.No. : Fgf2-7206M
Product Overview : Recombinant Mouse Fibroblast Growth Factor-2 without tag was expressed in E. coli.
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Description : Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
Source : E. coli
Species : Mouse
Form : Lyophilized freeze dried protein without additives.
Bio-activity : The activity was determined by the stimulation of HUVE cells. The ED50 for this effect is = 0.1 ng/mL corresponding to a specific activity of = 1 × 10^7 units/mg.
Molecular Mass : 16.34 kDa
AA Sequence : ALPEDGGAAFPPGHFKDPKRLYCKN GGFFLRIHPDGRVDGVREKSDPHVK LQLQAEERGVVSIKGVCANRYLAMK EDGRLLASKCVTEECFFFERLESNN YNTYRSRKYSSWYVALKRTGQYKLG SKGPGQKAILFLPMSAKSResultb yN-terminalsequencing:ALPEDGGAAF
Endotoxin : < 0.1 ng/μg of Mouse FGF-2
Purity : > 95 %
Storage : The lyophilized Mouse FGF-2, though stable at room temperature, is best stored in working aliquots at –20 to –70 centigrade.
Avoid repeated freeze-thaw cycles
Storage Buffer : PBS without stabilizers
Reconstitution : Restore with ddH2O or 50 mM Acetic Acid at 50 μg/mL. This solution can be diluted into other buffered solutions or stored frozen for future use.
Gene Name : Fgf2 fibroblast growth factor 2 [ Mus musculus (house mouse) ]
Official Symbol : Fgf2
Synonyms : Fgf2; fibroblast growth factor 2; Fgfb; bFGF; Fgf-2; Fgf2a; fibroblast growth factor 2; HBGF-2; basic fibroblast growth factor; fibroblast growth factor 2a; heparin-binding growth factor 2
Gene ID : 14173
mRNA Refseq : NM_008006
Protein Refseq : NP_032032
UniProt ID : P15655

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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Reviews
07/14/2022

    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

    02/04/2022

      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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