Active Recombinant Mouse Fgf2 Protein

• Cat.No.: Fgf2-7206M
• Product Overview: Recombinant Mouse Fibroblast Growth Factor-2 without tag was expressed in E. coli.

Specification

• Description: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
• Source: E. coli
• Species: Mouse
• Form: Lyophilized freeze dried protein without additives.
• Bio-activity: The activity was determined by the stimulation of HUVE cells. The ED50 for this effect is = 0.1 ng/mL corresponding to a specific activity of = 1 × 10^7 units/mg.
• Molecular Mass: 16.34 kDa
• AA Sequence: ALPEDGGAAFPPGHFKDPKRLYCKN GGFFLRIHPDGRVDGVREKSDPHVK LQLQAEERGVVSIKGVCANRYLAMK EDGRLLASKCVTEECFFFERLESNN YNTYRSRKYSSWYVALKRTGQYKLG SKGPGQKAILFLPMSAKSResultb yN-terminalsequencing:ALPEDGGAAF
• Endotoxin: < 0.1 ng/μg of Mouse FGF-2
• Purity: > 95 %
• Storage: The lyophilized Mouse FGF-2, though stable at room temperature, is best stored in working aliquots at –20 to –70 centigrade.
  Avoid repeated freeze-thaw cycles
• Storage Buffer: PBS without stabilizers
• Reconstitution: Restore with ddH2O or 50 mM Acetic Acid at 50 μg/mL. This solution can be diluted into other buffered solutions or stored frozen for future use.

Gene Information

• Gene Name: Fgf2 fibroblast growth factor 2 [ Mus musculus (house mouse) ]
• Official Symbol: Fgf2
• Synonyms: Fgf2; fibroblast growth factor 2; Fgfb; bFGF; Fgf-2; Fgf2a; fibroblast growth factor 2; HBGF-2; basic fibroblast growth factor; fibroblast growth factor 2a; heparin-binding growth factor 2
• Gene ID: 14173
• mRNA Refseq: NM_008006
• Protein Refseq: NP_032032
• UniProt ID: P15655

Reviews

07/14/2022

The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

02/04/2022

The purchased protein is suitable for WB experiments and I am satisfied with the results.

Q&As

What is the biological function of FGF2?

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed?

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed?

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with?

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in?

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis?

FGF2 negatively regulates bone homeostasis.