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Active Recombinant Human CD55 protein(Met1-Ser353), hFc-tagged

Cat.No. : CD55-64H
Product Overview : Recombinant Human CD55 protein(NP_000565.1)(Met1-Ser353), fused with C-terminal hFc tag, was expressed in HEK293.
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similar : CD55
Alias : CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); DAF, decay accelerating factor for complement (CD55, Cromer blood group system); complement decay-accelerating factor; CR; CROM; TC; CD55 antigen; DAF;
Source : HEK293
Species : Human
Conjugate : C-hFc
Tag : C-hFc
Protein length : Met1-Ser353
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bioactivity : Measured by its ability to bind human CD97-His in a functional ELISA.
MolecularMass : The recombinant human CD55/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 557 amino acids and has a predicted molecular mass of 61.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD55/Fc monomer is approximately 95-105 kDa due to glycosylation.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
GeneName : CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [ Homo sapiens ]
GeneNameWeblink : 1604
OfficialSymbol : CD55
OfficialSymbolWeblink : 1604
GeneID : 1604
GeneIDWeblink : 1604
mRNARefseq : NM_000574
mRNARefseqWeblink : NM_000574.3
ProteinRefseqWeblink : NP_000565.1
MIMWeblink : 125240
UniProtID : P08174
UniProtIDWeblink : P08174
Synonyms : CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); DAF, decay accelerating factor for complement (CD55, Cromer blood group system); complement decay-accelerating factor; CR; CROM; TC; CD55 antigen; DAF;
MIM : 125240
Synonyms : CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); DAF, decay accelerating factor for complement (CD55, Cromer blood group system); complement decay-accelerating factor; CR; CROM; TC; CD55 antigen; DAF;
MIM : 125240

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How do genetic variations in CD55 influence susceptibility to complement-mediated disorders, and what are the molecular mechanisms involved? 03/28/2022

Genetic variations in CD55 may influence susceptibility to complement-mediated disorders by affecting the protein's ability to regulate complement activation. This can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH).

How does CD55 contribute to the modulation of immune responses beyond its role in complement regulation? 05/22/2021

CD55 has immunomodulatory functions beyond complement regulation, influencing T cell responses and contributing to the maintenance of immune tolerance.

What role does CD55 play in protecting cells from complement-mediated lysis, and how does it contribute to immune evasion? 08/09/2019

CD55 protects cells from complement-mediated lysis by preventing the formation of membrane attack complexes. This contributes to immune evasion by pathogens and self-cells alike.

Can you elaborate on the structural domains of CD55 and how they mediate its interactions with complement components? 03/14/2018

CD55 consists of extracellular domains responsible for interactions with complement proteins, particularly C3b and C4b. These interactions prevent the formation of membrane attack complexes on host cells.

Can you discuss the involvement of CD55 in various diseases, including autoimmune disorders and infectious diseases? 01/06/2018

CD55 dysregulation is associated with autoimmune disorders, where it may contribute to immune system overactivity. Additionally, some pathogens exploit CD55 to evade host immune responses.

Customer Reviews (3)

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02/23/2022

    Efficient shipping and exceptional product quality. This company knows how to serve its customers.

    09/20/2019

      Consistency is key in research, and this product delivers that every time.

      03/02/2018

        We've tried various proteins, but this one stands out for its purity and performance.

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