Recombinant Human CXCL14, His-tagged

• Cat.No.: CXCL14-25H
• Product Overview: Recombinant Human CXCL14 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.6 kDa. The Human BRAK contains fusion His tag at N-Terminus. The BRAK is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CXCL14 is involved in immunoregulatory and inflammatory processes. BRAK protein is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. CXCL14 displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. CXCL14 is involved in the homeostasis of monocyte-derived macrophages.
• Amino Acid Sequence: MKHHHHHHAS SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: The protein was lyophilized from a concentrated (0.5mg/ml) solution containing 20mM Tris buffer & 20mM NaCl pH-7.5.
• Solubility: It is recommended to reconstitute the lyophilized CXCL14 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Storage: Lyophilized BRAK although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BRAK should be stored at 4°Cbetween 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: CXCL14 chemokine (C-X-C motif) ligand 14 [ Homo sapiens ]
• Synonyms: CXCL14; chemokine (C-X-C motif) ligand 14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; SCYB14; MGC10687; bolekine; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK);Small-inducible cytokine B14;C-X-C motif chemokine 14; UNQ240/PRO273; bolekine; CXC chemokine in breast and kidney; Chemokine BRAK; Chemokine BRAK; chemokine (C-X-C motif) ligand 14; small inducible cytokine subfamily B (Cys-X-Cys), member 14(BRAK)
• Gene ID: 9547
• mRNA Refseq: NM_004887
• Protein Refseq: NP_004878
• UniProt ID: O95715
• Chromosome Location: 5q31
• MIM: 604186
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity