| Species : |
Human |
| Source : |
HeLa |
| Tag : |
Non |
| Description : |
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene. |
| Form : |
Cell-Tissue Lysis buffer |
| Molecular Mass : |
39 kDa |
| Notes : |
Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins. |
| Storage : |
Store at -20 centigrade for two years. |
| Concentration : |
Lot-specific |
| Shipping : |
Blue Ice |
| Components : |
1 vial of 100 μg WT HeLa cell lysate
1 vial of 100 μg SSTR5 KD HeLa cell lysate |
| Protein Families : |
Druggable Genome, GPCR, Transmembrane |
| Protein Pathways : |
Neuroactive ligand-receptor interaction |
| Lysate QC : |
RT-qPCR; Western Blotting (WB) |
