Recombinant Human HDAC9 Protein, His-tagged


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Recombinant Human HDAC9 Protein, His-tagged

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Cat.No. : HDAC9-42H
Product Overview : Recombinant human HDAC9 protein with a C-terminal His-tag was expressed in insect cells.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Source : Insect cells
Species : Human
Tag : His
Molecular Mass : 50.7 kDa
Purity : ≥75% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris-HCl, pH 8.0, 137 mM sodium chloride, 2.7 mM potassium chloride, 1 mM magnesium chloride, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC class 2a substrate.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 200 mM imidazole
SDS-PAGE Analysis of HDAC9 :

Lane 1: MW Markers; Lane 2: HDAC9 (3.15 μg). Representative gel image shown; actual purity may vary between each batch.

HDAC9 Deacetylase Activity :

Gene Name : HDAC9 histone deacetylase 9 [ Homo sapiens (human) ]
Official Symbol : HDAC9
Synonyms : HDAC9; histone deacetylase 9; HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL; histone deacetylase 9; MEF-2 interacting transcription repressor (MITR) protein; histone deacetylase 4/5-related protein; histone deacetylase 7B
Gene ID : 9734
mRNA Refseq : NM_001204144
Protein Refseq : NP_001191073
MIM : 606543
UniProt ID : Q9UKV0
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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