Recombinant Human HDAC9 Protein, His-tagged

• Cat.No.: HDAC9-42H
• Product Overview: Recombinant human HDAC9 protein with a C-terminal His-tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
• Molecular Mass: 50.7 kDa
• Purity: ≥75% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris-HCl, pH 8.0, 137 mM sodium chloride, 2.7 mM potassium chloride, 1 mM magnesium chloride, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC class 2a substrate.
• Stability: ≥ 6 months
• Storage: Store it at -80 centigrade
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 200 mM imidazole

Gene Information

• Gene Name: HDAC9 histone deacetylase 9 [ Homo sapiens (human) ]
• Official Symbol: HDAC9
• Synonyms: HDAC9; histone deacetylase 9; HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL; histone deacetylase 9; MEF-2 interacting transcription repressor (MITR) protein; histone deacetylase 4/5-related protein; histone deacetylase 7B
• Gene ID: 9734
• mRNA Refseq: NM_001204144
• Protein Refseq: NP_001191073
• MIM: 606543
• UniProt ID: Q9UKV0