Recombinant Mouse Epcam Protein, His-tagged, Alexa Fluor 488 conjugated
Cat.No. : | Epcam-283MAF488 |
Product Overview : | Alexa Fluor 488 conjugated recombinant Mouse Epcam (Gln24-Thr266) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 28.5 kDa. The protein migrates as 33-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Gln24-Thr266 |
N-terminal Sequence Analysis : | Gln 24 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 98 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | Epcam |
Official Symbol : | Epcam |
Synonyms : | EPCAM; epithelial cell adhesion molecule; mEGP314; protein 289A; Trop-1 protein; lymphocyte antigen 74; epithelial glycoprotein 314; panepithelial glycoprotein 314; tumor-associated calcium signal transducer 1; EGP; Ly74; gp40; CD326; EGP-2; TROP1; Egp314; Ep-CAM; Tacsd1; GA733-2; Tacstd1 |
Gene ID : | 17075 |
mRNA Refseq : | NM_008532 |
Protein Refseq : | NP_032558 |
UniProt ID : | Q99JW5 |
Products Types
◆ Recombinant Protein | ||
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EPCAM-7818H | Recombinant Human EPCAM Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
EPCAM-350H | Recombinant Human EPCAM Protein, His & Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
EPCAM-2525HCL | Recombinant Human EPCAM cell lysate | +Inquiry |
EPCAM-1434RCL | Recombinant Rat EPCAM cell lysate | +Inquiry |
EPCAM-2143MCL | Recombinant Mouse EPCAM cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionEpCAM is highly expressed in epithelial tissues and some cancer cells.
It has a controversial role in cell adhesion, possibly contributing to both cell-cell adhesion and anti-adhesive properties.
EpCAM primarily functions in cell signaling, proliferation, and migration.
It often has a pro-tumorigenic role, promoting cancer cell proliferation, migration, and invasion.
EpCAM is used as a biomarker to detect and isolate circulating tumor cells.
Strategies include developing EpCAM-targeted therapies for cancer treatment.
Genetic alterations in EpCAM are linked to some hereditary cancer syndromes.
Customer Reviews (3)
Write a reviewReliable for assays, satisfied customer.
High-quality product, consistent results.
Quick delivery, product as described.
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