bmp2
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  • Official Full Name
  • bone morphogenetic protein 2
  • Background
  • The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
  • Synonyms
  • BMP2; bone morphogenetic protein 2; BDA2; BMP2A; BMP-2A; bone morphogenetic protein 2A
Cat.#:BMP2-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 2
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Cat.#:BMP2-22HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein-2
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Cat.#:BMP2-23HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP2
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Cat.#:BMP2&BMP7-709HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2&BMP7
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Cat.#:BMP2-10249HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2, GST-tagged
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Cat.#:BMP2-1119HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BMP2 protein
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Cat.#:BMP2-124HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP2, Fc-tagged
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Cat.#:BMP2-16HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMP2, Fc tagged
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Cat.#:BMP2-17HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human BMP2
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Cat.#:BMP2-210HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2 protein, His/S-tagged
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Cat.#:BMP2-259HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2 protein, His-tagged
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Cat.#:BMP2-260HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMP2 Protein, GST-tagged
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Cat.#:BMP2-261HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMP2 Protein, GST-tagged
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Cat.#:BMP2-31084THTag:
Source (Host):Species:Human
Product nameRecombinant Human BMP2
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Cat.#:BMP2-560HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2 protein, His & GST-tagged
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Cat.#:BMP2-561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2 protein, His-tagged
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Cat.#:BMP2-56HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP2, HIgG1 Fc-tagged, mutant
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Cat.#:Bmp2-211MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp2 protein, His/S-tagged
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Cat.#:BMP2-2430MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BMP2 Protein
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Cat.#:Bmp2-562MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp2 protein, His-tagged
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Cat.#:Bmp2-212RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp2 protein, His/S-tagged
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Cat.#:Bmp2-565RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp2 protein, His-tagged
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Cat.#:BMP2-996RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BMP2 Protein
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Cat.#:BMP2-558DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog BMP2 protein, His-tagged
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Cat.#:BMP2-559DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog BMP2 protein, His-tagged
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Cat.#:BMP2-566RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit BMP2 protein, His-tagged
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Cat.#:BMP2-5929CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BMP2
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Cat.#:BMP2-557CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle BMP2 protein, His & T7-tagged
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Cat.#:BMP2-563PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig BMP2 protein, His-tagged
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Cat.#:BMP2-564PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig BMP2 protein, His-tagged
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Cat.#:BMP2-567CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle BMP2 protein, His-tagged
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Cat.#:BMP2-30HTag:N/A
Source (Host):NativeSpecies:Human
Product nameHuman BMP2
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Cat.#:BMP2-867HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 2, His-tagged
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Cat.#:BMP2-3075HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMP2 cell lysate
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Cat.#:BMP2-119HGTag:
Source (Host):CHO cellSpecies:Human
Product nameGMP Recombinant Human BMP2 Protein
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Cat.#:BMP2-132HTag:
Source (Host):Species:Human
Product nameHuman Bone morphogenetic Protein-2 (rDNA derived) Reference standard
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Involved Pathway

Bmp2 involved in several pathways and played different roles in them. We selected most pathways Bmp2 participated on our site, such as Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bmp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PDGFC; EDA; PRP2; GM13304; TGFBR1; TGFB2; TNFRSF1B; AMHR2; IFNA6; CXCR6
Hedgehog signaling pathway
SKI; BMP4; CSNK1G1; PRKACAA; CSNK1DA; PTCH2; IHHA; Shh; WNT6; WNT8B
TGF-beta signaling pathway
LTBP1; ACVR1; RHOAA; RHOAC; RBX1; CUL1; TGFBR1; SMAD6; IFNG; ACVR1C
Hippo signaling pathway
CCND2; APC; FZD8; TGFBR2; ACTB; WNT6; BMP8A; WNT9B; SMAD3; SAV1
Signaling pathways regulating pluripotency of stem cells
AKT2; PIK3R1; ID2; RAF1; IGF1R; SMAD3; OTX1; AXIN1; WNT9B; IL6ST
Pathways in cancer
RXRG; TGFB3; GNG3; IL6; FGFR1; BRAF; TPM3; WNT11; ZBTB16; TRAF1
Basal cell carcinoma
BMP4; WNT11; WNT10B; PTCH1; BMP2; STK36; DVL1; DVL3; WNT9B; FZD1

Protein Function

Bmp2 has several biochemical functions, for example, BMP receptor binding, SMAD binding, co-receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bmp2 itself. We selected most functions Bmp2 had, and list some proteins which have the same functions with Bmp2. You can find most of the proteins on our site.
Function
Related Protein
Function BMP receptor binding
Related Protein BMP8A; BMP3; BMP7B; BMP2; BMP2B; BMP6; PYCARD; BMP7A; BMP5; BMP8B
Function SMAD binding
Related Protein PURA; HIPK2; ACVR1; ACVR1B; SKILB; SKOR1; TOB1; TGFBR3; ACVRL1; HMGA2
Function co-receptor binding
Related Protein NEO1; BMP2; HFE; TFR2; BMP4; DKK1
Function cytokine activity
Related Protein IL17A; IL17A/F2; BMP4; Ifnl2; GDF10; SCG2; NDR1; IL4; IL17B; GPR19
Function growth factor activity
Related Protein GDF5; F2; FGF2; LEFTY1; FGF6B; GDF7; LFT2; IGF3; VEGFB; CSF3
Function phosphatase activator activity
Related Protein BMP2; FRS2; GTF2F1
Function protein binding
Related Protein NEUROG3; CCDC88A; RPA2; GSG1L; HAND2; CCT2; IFITM1; COG4; IL24; SLC48A1
Function protein heterodimerization activity
Related Protein SOX17; PKNOX1; RELA; RBP4; BMP7A; ABCG8; HIST1H2B7; MCL1; HNF1B; TLX1
Function receptor binding
Related Protein HSPA1B; GFRA3; SMARCD1; SRI; PVRL1B; HLA-A; TENC1; NPY; MTSS1; FGF18A
Function retinol dehydrogenase activity
Related Protein ADH1; RDH12; RDH5; SDR9C7; DHRS3; DHRS7C; BMP2; ADH4; DHRS9; HSD17B6
Function transforming growth factor beta receptor binding
Related Protein LFT1; TGFB2; GDF9; GDF10B; BMP7B; INHBA; FKBP1A; GDF6; GDF15; NODAL

Interacting Protein

Bmp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bmp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Bmp2.
BMPR1A; FSTL1; BMPR1B; NOG; WFIKKN2

Bmp2 Related Articles

Olivares-Navarrete, R; Hyzy, SL; et al. Coordinated regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by endogenous bone morphogenetic proteins. BONE 73:208-216(2015).
Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).

Bmp2 Related Gene Family

TGF