| Official Full Name | bone morphogenetic protein 2 |
| Background | The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008] |
| Synonyms | BMP2; bone morphogenetic protein 2; BDA2; BMP2A; BMP-2A; bone morphogenetic protein 2A |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Bmp2 involved in several pathways and played different roles in them. We selected most pathways Bmp2 participated on our site, such as Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bmp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL4; GM1987; TNFRSF9; IL20RA; TNFB; M17; CCL26; TNFRSF18; IL1R2; CXCR3 |
| Hedgehog signaling pathway | WNT4; WNT7A; WNT8A; CSNK1DB; CSNK1G1; IHHB; GLI1; WNT1; WNT11R; SMO |
| TGF-beta signaling pathway | LEFTY2; ACVR1B; SMAD6; BMPR2B; TFDP1A; THBS1; TGFB1; SMAD3A; RBX1; MAPK3 |
| Hippo signaling pathway | APC2; ITGB2L; ACTB; BMP2; WNT5A; SMAD2; FZD5; YWHAE; SNAI2; DLG1 |
| Signaling pathways regulating pluripotency of stem cells | ESRRB; SOX2; NEUROG1; MAPK1; WNT6; WNT9B; HESX1; MAPK13; DLX5; SMAD5 |
| Pathways in cancer | SMAD2; GNGT2; GLI2; RALBP1; BMP2; MMP9; HRAS; GNG5; PIK3CD; LAMA2 |
| Basal cell carcinoma | APC2; WNT7B; WNT3A; GSK3B; FZD7; GLI2; TRP53; WNT2B; WNT8B; WNT2 |
Bmp2 has several biochemical functions, for example, BMP receptor binding, SMAD binding, co-receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bmp2 itself. We selected most functions Bmp2 had, and list some proteins which have the same functions with Bmp2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BMP receptor binding | BMP7B; BMP8B; BMP2B; BMP2; BMP6; BMP7A; BMP3; BMP5; PYCARD; BMP8A |
| SMAD binding | SKIB; TGFBRAP1; ACVR1B; SMAD2; COL3A1; SMURF2; RNF111; TCF12; CREBBP; DAB2 |
| co-receptor binding | BMP4; NEO1; BMP2; DKK1; TFR2; HFE |
| cytokine activity | IFNPHI4; IFNA3; IL36G; WNT5A; IL17F; INHBA; Ccl12; CCL19A.1; HMGB1B; IL3 |
| growth factor activity | INHA; INHBAB; GRN; BMP2B; FGF10; FGF16; NDR1; CD320; MSTN; GPI1 |
| phosphatase activator activity | GTF2F1; BMP2; FRS2 |
| protein binding | ITGA2; ZNF580; GIMAP7; TMEM106C; MALL; MCM2; YTHDC1; KPNB1; KCNA5; PRKCD |
| protein heterodimerization activity | BIRC5; HIST1H2AL; GTF2A1; BCL2L10; CLCF1; VEGFA; H2AFB3; CABYR; PDSS2; ATF4 |
| receptor binding | GUSB; Artn; HAO2; LAMA2; CXCL1; TNFSF15; CRAT; NOS2; LBP; CSK |
| retinol dehydrogenase activity | RDH8; ADH7; DHRS3; SDR9C7; ADH4; RDH5; AKR1C3; BMP2; RDH10; ADH1 |
| transforming growth factor beta receptor binding | LEFTY2; AMH; MSTN; GDF9; INHBAB; GDF15; INHBB; TGFBRAP1; INHBC; SPAW |
Bmp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bmp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Bmp2.
BMPR1A; FSTL1; BMPR1B; NOG; WFIKKN2
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