cxcl12
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 12
  • Background
  • SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.
  • Synonyms
  • CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B
Cat.#:CXCL12-1566HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12 (isoform alpha) Protein
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Cat.#:CXCL12-2160HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL12 Protein, GST-tagged
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Cat.#:CXCL12-3387HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12 Protein, MYC/DDK-tagged
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Cat.#:CXCL12-3920CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CXCL12 Protein
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Cat.#:CXCL12-4351RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CXCL12 Protein
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Cat.#:CXCL12-306HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12
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Cat.#:Cxcl12-371MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 12
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Cat.#:CXCL12-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stromal Cell-Dreived Factor 1α
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Cat.#:CXCL12-105HTag:Biotin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12
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Cat.#:CXCL12-133HTag:Biotin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, biotinylated
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Cat.#:CXCL12-20HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12, Fc tagged
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Cat.#:CXCL12-21HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, His-tagged
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Cat.#:CXCL12-31388THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12
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Cat.#:CXCL12-519HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12 protein, His & GST-tagged
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Cat.#:CXCL12-550HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant
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Cat.#:CXCL12-551HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, MIgG2a Fc-tagged
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Cat.#:CXCL12-552HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged
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Cat.#:CXCL12-629HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, None tagged
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Cat.#:CXCL12-64HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stromal Cell-Dreived Factor 1, His-tagged
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Cat.#:Cxcl12-11719MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant mouse Cxcl12, GST-tagged
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Cat.#:CXCL12-21MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Chemokine (C-X-C Motif) Ligand 12(SDF1b)
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Cat.#:CXCL12-391MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a)
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Cat.#:Cxcl12-42MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl12 protein, His-tagged
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Cat.#:Cxcl12-8661MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl12
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Cat.#:Cxcl12-111RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl12(SDF-1b)
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Cat.#:Cxcl12-521RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl12 protein, His & GST-tagged
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Cat.#:Cxcl12-65RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat SDF-1 alpha
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Cat.#:CXCL12-1107RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCL12 Protein, His-tagged
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Cat.#:CXCL12-1166RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus CXCL12 Protein, Fc-tagged
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Cat.#:CXCL12-383CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CXCL12
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Cat.#:CXCL12-6079CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCL12
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Cat.#:CXCL12-110FTag:N/A
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b)
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Cat.#:CXCL12-442HTag:
Source (Host):E. coliSpecies:Human/Feline
Product nameRecombinant Human/Feline CXCL12
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Cat.#:CXCL12-3016HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12 cell lysate
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Cat.#:CXCL12-1863CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CXCL12 cell lysate
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Involved Pathway

CXCL12 involved in several pathways and played different roles in them. We selected most pathways CXCL12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL11; IL22RA1; FLT3LG; CCL6; IL15; LTA; IL4; IL13; PDGFB; IL10
Chemokine signaling pathway
IL-8; PIK3R1; CCL26; NRAS; CCL5; ADRBK2; AKT2; NFKB1; PIK3CB; GRK7
NF-kappa B signaling pathway
TNFAIP3; PTGS2; SYK; PLAU; RELA; VCAM1; GM10591; CD40LG; PIDD1; BCL2L1
Axon guidance
PPP3R1; DPYSL5; SEMA6B; CNKSR1; KIF4; RAC1; PHB; DUSP5; DAB2IPB; DUSP2
Leukocyte transendothelial migration
CLDN7; VAV1; ICAM1; MYL5; PTK2B; JAM3; MYL2; ITGB1; PIK3R1; CD99
Intestinal i
MHC2DEB; HLA-DMB; HLA-DRB3; MHC2DAB; BMA1; IL-15RA; MADCAM1; HLA-DQA1; CD40LG; TNFRSF13B
ne network for IgA production
TNFRSF13B; HLA-DRB1; IL-15RA; H2-AB1; CD28; IL15; CXCL12B; CCR9A; HLA-DRA; Icosl
Pathways in cancer
FGF4; FLT3; Fasl; MSH2; FGF18; PRKACG; PDGFB; CXCL12; WNT16; TRAF3
Rheumatoid arthritis
ATP6V1G2; HLA-DOB; TNF; ACP5; HLA-DRB1; FLT1; GM-CSF; ATP6V0D2; Il23a; Il12b; TGFB1

Protein Function

CXCL12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL12 itself. We selected most functions CXCL12 had, and list some proteins which have the same functions with CXCL12. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein PPBP; CXCL5; CXCL12A; CXCL6; PF4V1; AMCF-II; IL8L2; CXCL12B; CXCL18B; CXCL3
Function chemoattractant activity
Related Protein SCG2; FIGF; VEGFA; VEGFB; FGF8; CCL5; MIF; HGF; VHL; FGF7
Function chemokine activity
Related Protein CCL14; CXCL11; CCL28; CCL38A.5; CXCL12B; CCL19A.1; AMCF-II; CCL38A.4; Ccl12; CCL18
Function chemokine receptor binding
Related Protein CCL19; Ccl21a; CCL21; CCL25; CCL5; CCL21B; CXCL12; Ccl21c; CCRL2; S100A14
Function growth factor activity
Related Protein TIMP1; RABEP1; IL7; GRN; FGF22; LEFTY1; KITLG; FGF12; CSF1; BMP15
Function receptor binding
Related Protein TNFSF12; WNT7A; GLA; HLA-E; NPY; CRTAM; CXCL12; PTK6B; NPPB; MBL2

Interacting Protein

CXCL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL12.
DPP4; DAZAP2

CXCL12 Related Articles

Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).

CXCL12 Related Gene Family

Chemokines Cytokines