| Official Full Name | fms-related tyrosine kinase 1 |
| Background | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009] |
| Synonyms | FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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FLT1 involved in several pathways and played different roles in them. We selected most pathways FLT1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PLD1; STK4; LAT; ELK1; GAB1; FGF21; CALM1; PDGFA; FGF3; PRKCG |
| Rap signaling pathway | GNAQ; FGF22; RAPGEF1; ANGPT2; MAP2K1; VASP; NGF; ITGB1; Fgf15; TEK |
| Cytokine-cytokine receptor interaction | IL5; NGFR; CX3CR1; CXCL13; VEGFC; CXCL3; INHBE; CCL3L1; TNFRSF19; CCL4 |
| HIF- signaling pathway | RPS6; RPS6KB1; IL6R; TCEB1; VEGFA; RELA; HK2; PIK3R5; CAMK2D; NOX3 |
| Endocytosis | HSP70L; CAPZB; ARFGAP3; TGFBR1A; AP2M1B; HSP70; VPS36; ARF3A; EEA1; WAS |
| PIK-Akt signaling pathway | GNG11; PPP2R5D; FN1; GNGT2; DDIT4; LPAR5; FGF18; FGFR3; PPP2R5A; SOS1 |
| Focal adhesion | ACTN1; MYLPFB; PPP1CC; GRB2B; VAV1; AKT3A; RHOAC; LAMC1; PPP1R12A; ITGAV |
| Transcriptional misregulation in cancer | BCL6; PTK2; ETV5; TMPRSS2; ZBTB16; FLI1; RUNX2; SFPI1; PPARG; ZEB1 |
| Rheumatoid arthritis | ATP6V0A4; CXCL5; ATP6V0A1; HLA-DPB1; IL-8; CXCL12; Il23a; TLR4; Ccl12; IL23 |
FLT1 has several biochemical functions, for example, ATP binding, VEGF-A-activated receptor activity, VEGF-B-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT1 itself. We selected most functions FLT1 had, and list some proteins which have the same functions with FLT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MYH1B; EPHB1; PNKP; TLK1B; ATP1A1B; PRKCDA; IPMK; ATAD1B; CDC34; SMG1 |
| VEGF-A-activated receptor activity | FLT1 |
| VEGF-B-activated receptor activity | FLT1 |
| growth factor binding | NRP2; GHR; ERBB3; LTBP4; NRP1; A2M; SDCBP; IGFBP2A; NKD2; GHRHR |
| placental growth factor-activated receptor activity | FLT1 |
| protein binding | ADARB1; Apba1; CASP9; TFF3; CTTNBP2NL; PACS1; TECR; PARP9; TRPC2; APBA2 |
| transmembrane receptor protein tyrosine kinase activity | EPHB3A; AXL; EPHB4; EGFRA; CSF1RA; ERBB2; EGFR; DDR2; EPHA4A; ROS1 |
| vascular endothelial growth factor-activated receptor activity | NRP1; NRP2B; FLT3; NRP1A; KDR; PDGFRA; NRP1B; FLT4; NRP2; NRP2A |
FLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT1.
VEGFA; PTPRJ; PGF; PIK3R1; VEGFA; CRKL
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