flt1
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  • Official Full Name
  • fms-related tyrosine kinase 1
  • Background
  • This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • Synonyms
  • FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);
Cat.#:FLT1-379RTag:MIgG2a Fc
Source (Host):HEK293Species:Rhesus Monkey
Product nameRecombinant Rhesus Monkey FLT1 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:FLT1-3810HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1 Protein, His-Avi-tagged, Biotinylated
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Cat.#:FLT1-2341HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1 Protein, MYC/DDK-tagged
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Cat.#:FLT1-4366HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT1 Protein
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Cat.#:FLT1-4367HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FLT1 Protein, GST-tagged
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Cat.#:FLT1-4369HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FLT1 Protein, GST-tagged
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Cat.#:FLT1-79HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, 4 Domains
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Cat.#:FLT1-80HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, 5 Domains
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Cat.#:FLT1-81HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, 5 Domains, Fc-tagged
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Cat.#:FLT1-82HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, 6 Domains
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Cat.#:FLT1-12HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FLT1 protein
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Cat.#:FLT1-190HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1 Protein, Fc-tagged
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Cat.#:FLT1-241HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FLT1, Fc Chimera
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Cat.#:FLT1-31708THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-31709THTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT1
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Cat.#:FLT1-31710THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-31711THTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT1
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Cat.#:FLT1-31713THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-31714THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-318HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FLT1, GST-tagged, Active
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Cat.#:FLT1-32HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-3809HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1, His tagged
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Cat.#:FLT1-530HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human FLT1 protein, His-tagged
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Cat.#:FLT1-544HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FLT1, His-tagged
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Cat.#:FLT1-615HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FLT1, Fc-tagged, Biotinylated
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Cat.#:FLT1-616HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FLT1, Fc-tagged
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Cat.#:FLT1-7650HTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT1
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Cat.#:FLT1-78HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, 3 Domains
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Cat.#:FLT1-938HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human FLT1 Protein, DDK-tagged
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Cat.#:FLT1-979HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 1, Fc Chimera
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Cat.#:Flt1-1785MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Flt1 Protein, His-tagged
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Cat.#:Flt1-1786MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Flt1 Protein, Fc-tagged
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Cat.#:Flt1-1838MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Flt1 protein, His-tagged
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Cat.#:FLT1-5927MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FLT1 Protein
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Cat.#:Flt1-8114MTag:mFc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Flt1 protein, mFc-tagged
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Cat.#:Flt1-1840RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Flt1 protein, His-tagged
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Cat.#:Flt1-1841RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Flt1 protein, His & T7-tagged
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Cat.#:FLT1-2364RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FLT1 Protein
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Cat.#:Flt1-8712RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Flt1, His tagged
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Cat.#:FLT1-5825CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FLT1
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Cat.#:FLT1-2299ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FLT1
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Cat.#:FLT1-1839PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig FLT1 protein, His & GST-tagged
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Cat.#:FLT1-1015HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), GST-tagged
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Cat.#:FLT1-1221HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
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Cat.#:FLT1-1222HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), His-tagged
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Cat.#:FLT1-1407HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FLT1 (Active), GST-tagged
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Cat.#:FLT1-899HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), His-tagged
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Cat.#:FLT1-1909HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT1 cell lysate
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Cat.#:FLT1-1207RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FLT1 cell lysate
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Cat.#:FLT1 & KDR-P1006HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FLT1/KDR, Fc-tagged therapeutic protein
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Cat.#:VEGFR1&VEGFR2-P019HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FLT1/VEGFR2, Fc-tagged therapeutic protein
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Cat.#:VEGFR1&VEGFR2-P09HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FLT1/VEGFR2, Fc-tagged therapeutic protein
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Involved Pathway

FLT1 involved in several pathways and played different roles in them. We selected most pathways FLT1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
CALM3; PLD2; REL; PIK3CA; Kitl; KLK1B4; GNB4; PIK3R5; CALM4; INS1
Rap signaling pathway
GRIN1; RHOA; FGFR1; RASGRP3; GNAO1; CALML5; FGF11; FGFR4; PLCE1; PLCB1
Cytokine-cytokine receptor interaction
EPOR; CCL20A.3; BMPR2; IL-8; IL7; IL12BA; PLEKHO2; IFN-a; CCL3L3; IFNA13
HIF- signaling pathway
ANGPT2; PFKFB3; CAMK2A; IL6R; IGF1; EPO; MAPK1; NPPA; INSR; VHL
Endocytosis
EPN1; ADRB3; IL2RB; WIPF1A; FAM125B; IGF1R; EHD2B; D6WSU116E; CAV3; ARRB2A
PIK-Akt signaling pathway
NR4A1; LAMC2; IL3RA; TSC1; FGF8; PHLPP2; YWHAZ; ITGA4; GH1; PRLR
Focal adhesion
COL24A1; ITGB6; GRB2A; HGF; VAV1; PRKCB; COL4A2; THBS3A; HRASB; ACTN1
Transcriptional misregulation in cancer
IL-8; KLF3; HIST1H3G; TSPAN7; IL2RB; LRP2BP; ETV5; RXRA; FCGR1A; PAX3
Rheumatoid arthritis
ATP6V1D; CXCL12; ATP6V0E2; IL-8; ANGPT1; ITGB2; IL23; Ccl12; HLA-DQA2; CXCL1

Protein Function

FLT1 has several biochemical functions, for example, ATP binding, VEGF-A-activated receptor activity, VEGF-B-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT1 itself. We selected most functions FLT1 had, and list some proteins which have the same functions with FLT1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PFKMA; DDX41; PAK2B; C10orf2; PRKCDA; NADSYN1; PSMC1; RECQL5; FAM20C; DAPK2
Function VEGF-A-activated receptor activity
Related Protein FLT1
Function VEGF-B-activated receptor activity
Related Protein FLT1
Function growth factor binding
Related Protein IL6ST; TEK; ACVR1C; IGFBP2B; FGFBP2; OSMR; GHRHR; LIFR; FLT4; KDR
Function placental growth factor-activated receptor activity
Related Protein FLT1
Function protein binding
Related Protein SCARB2; UFC1; F10; KIF20A; HSPA13; DOCK4; NISCH; EYA3; NDUFS7; C1orf182
Function transmembrane receptor protein tyrosine kinase activity
Related Protein MUSK; EPHB2B; EPHB3A; EPHA2; KITA; EGFR; IGF1RB; RET; EGFRA; ERBB2
Function vascular endothelial growth factor-activated receptor activity
Related Protein FLT4; PDGFRA; NRP2; NRP2A; FLT1; FLT3; NRP2B; KDR; NRP1B; NRP1

Interacting Protein

FLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT1.
VEGFA; PTPRJ; PGF; PIK3R1; VEGFA; CRKL

FLT1 Related Articles

Ahmadova, Z; Yagublu, V; et al. Fluorescent Resonance Energy Transfer Imaging of VEGFR Dimerization. ANTICANCER RESEARCH 34:2123-2133(2014).
Suspitsin, EN; Kashyap, A; et al. Evidence for angiogenesis-independent contribution of VEGFR1 (FLT1) in gastric cancer recurrence. MEDICAL ONCOLOGY 30:-(2013).