gdnf
Share
  • Official Full Name
  • glial cell derived neurotrophic factor
  • Background
  • This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
  • Synonyms
  • GDNF; glial cell derived neurotrophic factor; ATF1; ATF2; HSCR3; HFB1-GDNF; glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor;
Cat.#:GDNF-4835HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDNF Protein, GST-tagged
+Inquiry
Cat.#:GDNF-637HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDNF Protein
+Inquiry
Cat.#:GDNF-708HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GDNF Protein
+Inquiry
Cat.#:Gdnf-359RTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Rat
Product nameRecombinant Rat Glial Cell Derived Neurotrophic Factor
+Inquiry
Cat.#:GDNF-15HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDNF Protein, His/S-tagged
+Inquiry
Cat.#:GDNF-22HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human GDNF, His-tagged
+Inquiry
Cat.#:GDNF-26274THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDNF
+Inquiry
Cat.#:GDNF-338HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Glial Cell Derived Neurotrophic Factor
+Inquiry
Cat.#:GDNF-7292HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDNF, None tagged
+Inquiry
Cat.#:GDNF-7293HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDNF protein, Fc/His-tagged
+Inquiry
Cat.#:GDNF-778HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDNF protein, His-tagged
+Inquiry
Cat.#:GDNF-8858HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human GDNF,His-tagged
+Inquiry
Cat.#:GDNF-985HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GDNF
+Inquiry
Cat.#:Gdnf-16MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse GDNF Protein, His/S-tagged
+Inquiry
Cat.#:Gdnf-249MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdnf
+Inquiry
Cat.#:GDNF-6293MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GDNF Protein
+Inquiry
Cat.#:Gdnf-779MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdnf protein, His-tagged
+Inquiry
Cat.#:Gdnf-250RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Glial Cell Derived Neurotrophic Factor
+Inquiry
Cat.#:Gdnf-595RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gdnf
+Inquiry
Cat.#:Gdnf-7431RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Gdnf, His tagged
+Inquiry
Cat.#:Gdnf-780RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gdnf protein, His-tagged
+Inquiry
Cat.#:GDNF-1066CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine GDNF Protein, Fc-tagged
+Inquiry
Cat.#:GDNF-1549HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDNF cell lysate
+Inquiry
Cat.#:GDNF-400RCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat GDNF cell lysate
+Inquiry
Cat.#:GDNF-133HGTag:
Source (Host):NS0Species:Human
Product nameGMP Recombinant Human GDNF Protein
+Inquiry
Cat.#:GDNF-34HTag:
Source (Host):Species:Human
Product nameHuman Glial cell line-derived neurotrophic factor Reference standard
+Inquiry

Involved Pathway

GDNF involved in several pathways and played different roles in them. We selected most pathways GDNF participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDNF were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
KDR; ROBO2; SEMA3AA; AP2B1; SEMA3D; COL9A1A; DUSP5; SCN3B; KRAS; UNC5D
Developmental Biology
ITGB1B.1; EZRA; GFRA4; PRDM14; ARPC5; NR5A1; SCN3B; SPTBN2; MED22; CLTB
NCAM signaling for neurite out-growth
GFRA1; GDNF; NRTN; PSPN; COL9A1B; GFRA4; ST8SIA2; GFRA2; COL9A1A
NCAM1 interactions
COL9A1B; COL9A1A; GFRA1; PSPN; GDNF; NRTN; GFRA2; GFRA4
Signaling events regulated by Ret tyrosine kinase
DOK6; PDLIM7; GFRA1; DOK4; GDNF; DOK5
Spinal Cord Injury
PTPRZ1; RGMA; RTN4; NOX4; GAP43; TNFSF13B; LGALS3; GDNF; KLK8; AIF1

Protein Function

GDNF has several biochemical functions, for example, growth factor activity, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDNF itself. We selected most functions GDNF had, and list some proteins which have the same functions with GDNF. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein VHL; FGF12; GDNFA; FGF8B; NENF; PDGFC; TDGF1; KLK1B4; AREG; NRG2
Function protein binding
Related Protein SNX31; JUB; RASL10B; ERGIC2; TCF7L1A; ULK2; NAPB; KHDRBS3; LSM10; IFITM3
Function protein homodimerization activity
Related Protein TDG; GRIK2; ABCD1; RAB11FIP4A; IL12B; GSTA4; G6PD; ATP2A1; ZHX3; MTHFD1L
Function receptor binding
Related Protein FGF8A; ANKRD13C; PKD2; FGF6A; FGF20A; GCG; CLCF1; NTF7; AKAP9; LAMA1

Interacting Protein

GDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of GDNF.
AGTRAP; NDUFS6

GDNF Related Articles

Battaglia, G; Riozzi, B; et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 74:126-136(2015).
Lajoie, JM; Shusta, EV; et al. Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 55:613-631(2015).