|Official Full Name||glial cell derived neurotrophic factor|
|Background||This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]|
|Synonyms||GDNF; glial cell derived neurotrophic factor; ATF1; ATF2; HSCR3; HFB1-GDNF; glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GDNF involved in several pathways and played different roles in them. We selected most pathways GDNF participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||DPYSL5; CSF2RA; SPRED3; EZRA; RHOC; GPC1B; ROCK1; PLXNC1; NFATC3; EPHB1|
|Developmental Biology||MYL12B; FRS3; HIF3A; CDK8; SMAD3B; ADAM22; PCSK6; DOCK1; MYF6; COL6A2|
|NCAM signaling for neurite out-growth||GFRA1; COL9A1B; GFRA4; COL9A1A; NRTN; GDNF; GFRA2; ST8SIA2; PSPN|
|NCAM1 interactions||GFRA1; PSPN; COL9A1A; COL9A1B; NRTN; GFRA4; GDNF; GFRA2|
|Signaling events regulated by Ret tyrosine kinase||GFRA1; DOK6; PDLIM7; DOK5; GDNF; DOK4|
|Spinal Cord Injury||RGMA; KLK8; RTN4; AIF1; NOX4; GDNF; MBP; PTPRZ1; GAP43; OMG|
GDNF has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by GDNF itself. We selected most functions GDNF had, and list some proteins which have the same functions with GDNF. You can find most of the proteins on our site.
|growth factor activity||GDF6; GH1; FGF20; PDGFC; OSGIN1; JAG1; BMP2B; FGF22; NDR1; NRG2|
|protein binding||TRIM42; RAI1; SPIN1; PSMD4; RWDD3; DLA; CTNNA1; MRPL40; PDCD2; TBX5A|
|protein homodimerization activity||P2RX4; DMRTA1; UGT1A1; S100A16; UNC13A; APOE; CCBL2; USH1G; DMRTB1; STK10|
|receptor binding||A2M; TNFSF12; DECR2; NRG2A; BAAT; MSN; SSFA2; RIPK2; PSPN; LPL|
GDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of GDNF.