GDNF

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GDNF

Official Full Name glial cell derived neurotrophic factor
Background This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
Synonyms GDNF; glial cell derived neurotrophic factor; ATF1; ATF2; HSCR3; HFB1-GDNF; glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor;
    • Species :
    • Canine
    • Human
    • Mouse
    • Rat
    • Source :
    • Barley Grain
    • CHO
    • E.coli
    • HEK293
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDNF-133HG GMP Recombinant Human GDNF Protein NS0 N/A
    Human GDNF-1549HCL Recombinant Human GDNF cell lysate Human Cell N/A
    Human GDNF-15H Recombinant Human GDNF Protein, His/S-tagged E.coli His/S
    Human GDNF-22H Recombinant Human GDNF, His-tagged Barley Grain His
    Human GDNF-26274TH Recombinant Human GDNF E.coli N/A
    Human GDNF-338H Recombinant Human Glial Cell Derived Neurotrophic Factor NSO N/A
    Human GDNF-34H Human Glial cell line-derived neurotrophic factor Reference standard N/A
    Human GDNF-4835H Recombinant Human GDNF Protein, GST-tagged Wheat Germ GST
    Human GDNF-637H Recombinant Human GDNF protein E.coli N/A
    Human GDNF-708H Recombinant Human GDNF Protein CHO N/A
    Human GDNF-7292H Recombinant Human GDNF, None tagged Human Cell N/A
    Human GDNF-7293H Recombinant Human GDNF protein, Fc/His-tagged HEK293 Fc/His
    Human GDNF-778H Recombinant Human GDNF protein, His-tagged E.coli His
    Human GDNF-8858H Recombinant Human GDNF,His-tagged Hordeum Vulgare N/A
    Human GDNF-985H Recombinant Human GDNF CHO N/A
    Mouse Gdnf-16M Recombinant Mouse GDNF Protein, His/S-tagged E.coli His/S
    Mouse Gdnf-249M Recombinant Mouse Gdnf protein E.coli N/A
    Mouse GDNF-6293M Recombinant Mouse GDNF Protein Mammalian Cell His
    Mouse Gdnf-779M Recombinant Mouse Gdnf protein, His-tagged E.coli His
    Rat Gdnf-250R Recombinant Rat Glial Cell Derived Neurotrophic Factor E.coli N/A
    Rat Gdnf-359R Recombinant Rat Glial Cell Derived Neurotrophic Factor Sf21 Insect Cell N/A
    Rat GDNF-400RCL Recombinant Rat GDNF cell lysate Insect Cell N/A
    Rat Gdnf-595R Recombinant Rat Gdnf protein E.coli N/A
    Rat Gdnf-7431R Recombinant Rat Gdnf, His tagged Insect Cell His
    Rat Gdnf-780R Recombinant Rat Gdnf protein, His-tagged E.coli His
    Canine GDNF-1066C Recombinant Canine GDNF Protein, Fc-tagged HEK293 Fc

    GDNF involved in several pathways and played different roles in them. We selected most pathways GDNF participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance DPYSL5; CSF2RA; SPRED3; EZRA; RHOC; GPC1B; ROCK1; PLXNC1; NFATC3; EPHB1
    Developmental Biology MYL12B; FRS3; HIF3A; CDK8; SMAD3B; ADAM22; PCSK6; DOCK1; MYF6; COL6A2
    NCAM signaling for neurite out-growth GFRA1; COL9A1B; GFRA4; COL9A1A; NRTN; GDNF; GFRA2; ST8SIA2; PSPN
    NCAM1 interactions GFRA1; PSPN; COL9A1A; COL9A1B; NRTN; GFRA4; GDNF; GFRA2
    Signaling events regulated by Ret tyrosine kinase GFRA1; DOK6; PDLIM7; DOK5; GDNF; DOK4
    Spinal Cord Injury RGMA; KLK8; RTN4; AIF1; NOX4; GDNF; MBP; PTPRZ1; GAP43; OMG

    GDNF has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by GDNF itself. We selected most functions GDNF had, and list some proteins which have the same functions with GDNF. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity GDF6; GH1; FGF20; PDGFC; OSGIN1; JAG1; BMP2B; FGF22; NDR1; NRG2
    protein binding TRIM42; RAI1; SPIN1; PSMD4; RWDD3; DLA; CTNNA1; MRPL40; PDCD2; TBX5A
    protein homodimerization activity P2RX4; DMRTA1; UGT1A1; S100A16; UNC13A; APOE; CCBL2; USH1G; DMRTB1; STK10
    receptor binding A2M; TNFSF12; DECR2; NRG2A; BAAT; MSN; SSFA2; RIPK2; PSPN; LPL

    GDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of GDNF.

    AGTRAP; NDUFS6

    Battaglia, G; Riozzi, B; et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 74:126-136(2015).
    Lajoie, JM; Shusta, EV; et al. Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 55:613-631(2015).

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