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Il1rn

  • Official Full Name

    interleukin 1 receptor antagonist

  • Overview

    The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
  • Synonyms

    IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Antibody
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Equine
  • Horse
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus monkey (Simian)
  • Bacillus subtilis
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Yeast
  • C
  • His
  • Flag
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Met
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Fc
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1RN-115H Active Recombinant Human Interleukin 1 Receptor Antagonist HEK293 N/A
Human IL1RN-188H Active Recombinant Human IL1RN protein(Arg26-Glu177) E. coli N/A Arg26-Glu177
Human IL1RN-05H Recombinant Human IL1RN protein E.coli N/A 152
Human IL1RN-314H Recombinant Human IL1RN protein, hFc-tagged HEK293 hFc Arg26-Glu177
Human IL1RN-495H Recombinant Human IL1RN protein, His-tagged HEK293F His Arg26~Glu177
Human IL1RN-28733TH Recombinant Human IL1RN, His-tagged E.coli His
Human IL1RN-51H Recombinant Human Interleukin 1 Receptor Antagonist, His-tagged E.coli His
Human IL1RN-2912HCL Recombinant Human IL1RN cell lysate Human Cell N/A
Human IL1RN-121H Human Interleukin-1 Receptor Antagonist(rDNA derived) Reference standard N/A
Human IL1RN-1819H Recombinant Human IL1RN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL1RN-1893HFL Recombinant Full Length Human IL1RN Protein, C-Flag-tagged Mammalian cells Flag
Human IL1RN-5230H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1RN-104H Active Recombinant Human IL1RN Protein E.coli Arg26-Glu177
Human DMABT-H18692 Mouse Anti-IL1RN Monoclonal Antibody Mouse N/A
Human IL1RN-1171H Recombinant Human IL1RN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL1RN-167H Recombinant Active Human IL1RN Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL1RN-3596H Recombinant Human IL1RN protein, His-tagged E.coli His 159aa
Human IL1RN-153H Active Recombinant Human IL1RN Protein E.coli
Human IL1RN-103I Active Recombinant Human IL1RN Protein (153 aa) E.coli 153
Human IL1RN-P038H Recombinant Human IL1RN therapeutic protein E.coli N/A 153 aa
Human IL1RN-104I Active Recombinant Human IL1RN Protein (153 aa) E.coli 153
Human IL1RN-183I Active Recombinant Human IL1RN Protein HEK293
Human IL1RN-3350H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1RN-055H Recombinant Human IL1RN Protein 177
Human IL1RN-3569H Recombinant Human IL1RN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1RN-0586H Recombinant Human IL1RN Protein (Arg26-Glu177), C-His-tagged Bacillus subtilis C-His Arg26-Glu177
Human IL1RN-164H Active Recombinant Human IL1RN Protein (Arg26-Glu177), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg26-Glu177
Human IL1RN-1171H-B Recombinant Human IL1RN Protein Pre-coupled Magnetic Beads HEK293
Human IL1RN-2468H Recombinant Human IL1RN Protein (Arg26-Glu177), His tagged E.coli His Arg26-Glu177
Human IL1RN-4269H Recombinant Human IL1RN Protein (Arg26-Glu177), N-Fc tagged Mammalian cells N-Fc Arg26-Glu177
Mouse Il1rn-01M Active Recombinant Mouse Il1rn Protein, His-Tagged E.coli His
Mouse Il1rn-5593M Recombinant Mouse Interleukin 1 Receptor Antagonist, His-tagged E.coli His
Mouse Il1rn-546M Recombinant Mouse Il1rn protein E.coli N/A 152
Mouse Il1rn-15856M Recombinant Mouse Il1rn, His-tagged E.coli His 27-178aa
Mouse Il1rn-231M Recombinant Mouse Interleukin-1 Receptor Antagonist E.coli N/A
Mouse Il1rn-56M Active Recombinant Mouse Il1rn Protein (Arg27-Gln178), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg27-Gln178
Mouse Il1rn-1244M Recombinant Mouse Il1rn Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il1rn-6741M Recombinant Mouse Il1rn Protein (Arg27-Gln178) E.coli Tag Free Arg27-Gln178
Mouse Il1rn-168M Recombinant Active Mouse IL1RN Protein, His-tagged(C-ter) E.coli His(C-ter)
Rat Il1rn-574R Recombinant Rat Il1rn protein E.coli N/A 152
Rat Il1rn-8709R Active Recombinant Rat Il1rn protein, hFc-tagged HEK293 hFc His27-Gln178
Rat Il1rn-107R Recombinant Rat Il1rn, His-tagged E.coli His
Rat IL1RN-3037R Recombinant Rat IL1RN Protein Mammalian Cell His
Rat IL1RN-1375RCL Recombinant Rat IL1RN cell lysate Human Cell N/A
Rat Il1rn-2299R Recombinant Rat Il1rn Protein, His-tagged E.coli N-His His27-Gln178
Rat IL1RN-2692R-B Recombinant Rat IL1RN Protein Pre-coupled Magnetic Beads HEK293
Rat IL1RN-103R Recombinant Rat IL1RN Protein, His-tagged HEK293 His
Rat IL1RN-2692R Recombinant Rat IL1RN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit IL1RN-254R Recombinant Rabbit IL1RN Protein, His-tagged E.coli His Arg26~Gln177
Rabbit IL1RN-4363R Recombinant Rabbit IL1RN Protein Yeast N/A 150aa
Dog IL1RN-249D Recombinant Dog IL1RN Protein, His-tagged E.coli His Arg26~Glu176
Cattle IL1RN-248C Recombinant Cattle IL1RN Protein, His-tagged E.coli His His24~Asp174
Cynomolgus IL1RN-094C Recombinant Cynomolgus IL1RN protein, His-tagged E.coli His His27-Gln178
Cynomolgus IL1RN-10C Recombinant Cynomolgus IL1RN Protein, His-tagged HEK293 His
Cynomolgus IL1RN-0278C Recombinant Cynomolgus IL1RN protein, His-tagged E.coli His Arg26-Glu177
Cynomolgus Monkey IL1RN-615C Recombinant Cynomolgus IL1RN Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IL1RN-362C-B Recombinant Cynomolgus Monkey IL1RN Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL1RN-362C Recombinant Cynomolgus Monkey IL1RN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Equine IL1RN-945E Active Recombinant Equine IL1RN E.coli Met His26-Gln177
Horse IL1RN-250H Recombinant Horse IL1RN Protein, His-tagged E.coli His His26~Gln177
Horse IL1RN-602H Recombinant Horse IL1RN protein E.coli N/A 152
Rhesus monkey (Simian) IL1RN-255R Recombinant Rhesus monkey IL1RN Protein, His-tagged E.coli His Arg26~Glu177
Pig IL1RN-253P Recombinant Pig IL1RN Protein, His-tagged E.coli His His26~Gln177
Pig IL1RN-89P Recombinant Pig IL1RN protein E.coli N/A 152
Chicken IL1RN-4645C Recombinant Chicken IL1RN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Il1rn Related Articles
  • Il1rn Related Gene Family

Il1rn involved in several pathways and played different roles in them. We selected most pathways Il1rn participated on our site, such as Cytokine Signaling in Immune system, IL-1 Signaling Pathway, IL1-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1rn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemOSTN;KLB;NUP35;ISG20;TRIM29;IFIT8;TRIM14;RASGRP4;IFIT3
IL-1 Signaling PathwayIL1RN;SIRPA;IKBKAP
IL1-mediated signaling eventsIL1RN;TMED7-TICAM2;IRAK3;TMEM189-UBE2V1
Immune SystemDZIP3;PAG1;IFIT14;DEFA5;SH3RF1;DEFB116;PANX1A;CLEC4A;BST2
Interleukin-1 signalingIRAK3;PELI1;PELI2;TNIP2;IL1RN;NOD1;PELI3
Leptin signaling pathwayKHDRBS1;CFL2;IL1RN
SIDS Susceptibility PathwaysKCNJ8;KCNQ1;TSPYL1;SST;FOXM1;MAZ;POU2F2;DEAF1;RUNX3
Signaling by InterleukinsCASPB;HAVCR2;SOCS3A;CASPBL;IL1RN;LGALS9

Il1rn has several biochemical functions, for example, cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1rn itself. We selected most functions Il1rn had, and list some proteins which have the same functions with Il1rn. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTGFB2;IFNA8;IL22;BMP5;BMP8A;TSLP;CMTM4;INHBAA;IL20
interleukin-1 Type I receptor antagonist activity
interleukin-1 Type II receptor antagonist activity
interleukin-1 receptor antagonist activityIl1f5;IL1RN;IL36RN
interleukin-1 receptor bindingIL1A;IL1RAP;IL1F10;IL1RN;IL36G;IL37;IL36A;Il1f6;IRAK4
interleukin-1, Type I receptor bindingTOLLIP;IL1RN
interleukin-1, Type II receptor bindingIL1RN;ERAP1
protein bindingFGFR1OP2;DTX2;STAT5A;RHOBTB3;PTPRN;DEF6;HER5;CRIPAK;CD80

Il1rn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1rn here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1rn.

TERF2IP; IL1R1; POT1

Levin, EC; Debbaneh, M; et al. Biologic Therapy in Erythrodermic and Pustular Psoriasis. JOURNAL OF DRUGS IN DERMATOLOGY 13:342-354(2014).
Zaaber, I; Mestiri, S; et al. Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto's thyroiditis. AUTOIMMUNITY 47:113-118(2014).
IL
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