mapt
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  • Official Full Name
  • microtubule-associated protein tau
  • Background
  • This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimers disease, Picks disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1;
Cat.#:MAPT-646RTag:His|SUMO
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque MAPT Protein (2-459 aa), His-SUMO-tagged
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Cat.#:MAPT-647RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat MAPT Protein (2-752 aa), His-tagged
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Cat.#:MAPT-100HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-121HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (1-391)
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Cat.#:MAPT-122HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (1-421)
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Cat.#:MAPT-123HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (G272V)
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Cat.#:MAPT-124HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (K257T)
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Cat.#:MAPT-125HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (N279K)
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Cat.#:MAPT-127HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT Protein, His-tagged
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Cat.#:MAPT-133HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (dK280)
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Cat.#:MAPT-134HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (dN296)
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Cat.#:MAPT-135HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (L266V)
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Cat.#:MAPT-136HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (P301L)
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Cat.#:MAPT-137HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (P301S)
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Cat.#:MAPT-138HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (R406W)
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Cat.#:MAPT-139HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S198A)
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Cat.#:MAPT-140HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S198E)
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Cat.#:MAPT-141HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S199E)
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Cat.#:MAPT-142HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S214A)
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Cat.#:MAPT-143HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S305N)
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Cat.#:MAPT-144HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S352L)
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Cat.#:MAPT-145HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S404A)
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Cat.#:MAPT-146HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (S404E)
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Cat.#:MAPT-156HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (50-391)
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Cat.#:MAPT-157HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (50-421)
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Cat.#:MAPT-158HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (50-441)
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Cat.#:MAPT-159HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (V337M)
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Cat.#:MAPT-168HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (127-421)
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Cat.#:MAPT-169HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (151-391)
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Cat.#:MAPT-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (151-421)
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Cat.#:MAPT-171HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (151-441)
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Cat.#:MAPT-172HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (231-441)
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Cat.#:MAPT-173HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (99-441)
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Cat.#:MAPT-186HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (216-391)
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Cat.#:MAPT-187HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (231-391)
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Cat.#:MAPT-188HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (231-421)
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Cat.#:MAPT-189HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 (244-372)
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Cat.#:MAPT-204HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT(A152T) protein
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Cat.#:MAPT-20HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPT protein, MYC/DDK-tagged
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Cat.#:MAPT-218HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-21HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPT protein, MYC/DDK-tagged
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Cat.#:MAPT-2874HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT, His-tagged
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Cat.#:MAPT-30090THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-30091THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-30093THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-30138THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-38HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tau-441 protein, phosphorylated
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Cat.#:MAPT-49HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT (N352H)
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Cat.#:MAPT-5073HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Microtubule-Associated Protein Tau, His-tagged
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Cat.#:MAPT-5074HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Microtubule-Associated Protein Tau, His-tagged
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Cat.#:MAPT-528HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT, His tagged
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Cat.#:MAPT-94HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-95HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-96HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-97HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:MAPT-98HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPT
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Cat.#:Mapt-19MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mapt protein, His-tagged
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Cat.#:Mapt-20MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Mapt protein, His-tagged
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Cat.#:Mapt-2062RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mapt protein, His & T7-tagged
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Cat.#:MAPT-4246CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPT
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Cat.#:MAPT-1572HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Microtubule-Associated Protein Tau
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Cat.#:MAPT-4476HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPT 293 Cell Lysate
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Cat.#:MAPT-4477HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPT 293 Cell Lysate
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Cat.#:MAPT-4478HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPT 293 Cell Lysate
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Involved Pathway

MAPT involved in several pathways and played different roles in them. We selected most pathways MAPT participated on our site, such as MAPK signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NFATC3; MAPK3; CACNG4; MAP2K7; PRKACG; RAF1; PPP3CCB; MAP3K3; PAK1; PPP3R1
Alzheimers disease
NDUFA3; NDUFA12; COX7A2; COX4I2; ITPR3; MAPK1; LPL; APH1B; APAF1; IDE

Protein Function

MAPT has several biochemical functions, for example, SH3 domain binding, apolipoprotein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPT itself. We selected most functions MAPT had, and list some proteins which have the same functions with MAPT. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein ADAM17; MYPN; CABYR; ENKUR; SH2D2A; PTTG2; DRD4; ELMO2; LRP2; NOXA1
Function apolipoprotein binding
Related Protein PLG; LRP1; LIPC; VLDLR; ABCA1; SCARB1; LPA; CANX; PCSK9; MAPT
Function enzyme binding
Related Protein BTG1; USP22; TULP3; SCNM1; EGFR; PLSCR1; SLC27A2; PARP1; MST1R; PARP4
Function lipoprotein particle binding
Related Protein APOE; CDH13; MAPT; GPIHBP1
Function microtubule binding
Related Protein NEIL2; GOLSYN; GABARAPA; CETN2; SGIP1; MAPRE1B; PLK1; SKA2; CRIPT; KIF1C
Function protein binding
Related Protein RAP1GAP; VEGFA; AUP1; JPH2; APC; CENPI; TAF10; CTBP2; GNAI1; STAT5B
Function protein kinase binding
Related Protein PIWIL1; LIPE; RFFL; PDGFRB; TICAM1; PPME1; CCNB3; CCNY; RPS6KA3; CDK5RAP3
Function protein phosphatase 2A binding
Related Protein PPME1; SHC1; EIF4EBP1; TP53; SMG5; SPHK1; MASTL; ANKLE2; RPS6KB1; GRIN3A
Function structural constituent of cytoskeleton
Related Protein TUBAL3; TUBA8; TUBA3D; ARPC1B; YEATS4; DSP; KRT5; ARPC5; BKJ; CCDC6

Interacting Protein

MAPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPT here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPT.
YWHAZ; APP; MARK2; APOE

MAPT Related Articles

Xu, H; Rosler, TW; et al. Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40:833-843(2014).
Karageorgiou, E; Miller, BL; et al. Frontotemporal Lobar Degeneration: A Clinical Approach. SEMINARS IN NEUROLOGY 34:189-201(2014).