saa1
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  • Official Full Name
  • serum amyloid A1
  • Background
  • This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
  • Synonyms
  • SAA1; serum amyloid A1; SAA; serum amyloid A protein; PIG4; TP53I4; tumor protein p53 inducible protein 4; SAA2; MGC111216
Cat.#:SAA1-1052HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SAA Protein
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Cat.#:SAA1-795HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse SAA1 Protein (1-110 aa), His-tagged
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Cat.#:SAA1-1364DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog SAA1 Protein, His-GST-tagged
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Cat.#:SAA1-1363CTag:His-B2M
Source (Host):E. coliSpecies:Cat
Product nameRecombinant Cat SAA1 Protein, His-B2M-tagged
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Cat.#:Apo-SAA1-3553HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Apo-SAA1
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Cat.#:Apo-SAA-3552HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Apo-SAA
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Cat.#:SAA1-1403HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Serum Amyloid A1
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Cat.#:SAA1-2497HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SAA1, GST-tagged
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Cat.#:SAA1-2668HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Serum Amyloid A1
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Cat.#:SAA1-31162THTag:
Source (Host):Species:Human
Product nameRecombinant Human SAA1
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Cat.#:SAA1-31166THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SAA1, His-tagged
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Cat.#:SAA1-14633MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SAA1 Protein
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Cat.#:Saa1-185MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Saa1 Protein
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Cat.#:Saa1-7876MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Saa1 protein, His-tagged
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Cat.#:SAA1-4941MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Serum Amyloid A1
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Cat.#:SAA1-5110HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Serum Amyloid A1, His-tagged
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Cat.#:SAA1-5197RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus macaque Serum Amyloid A1
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Cat.#:SAA1-2080HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SAA1 293 Cell Lysate
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Cat.#:SAA1-2081HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SAA1 293 Cell Lysate
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Cat.#:SAA1-23HTag:
Source (Host):Species:Human
Product nameHuman SAA Reference Standard
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Involved Pathway

SAA1 involved in several pathways and played different roles in them. We selected most pathways SAA1 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
RIPK3; S100B; TAB1; IRAK3; ATF2; DUSP3B; PELI1; MAP3K8; TANK; DHX9
Advanced glycosylation endproduct receptor signaling
ALCAMB; APPB; DDOST; LGALS3; SAA1; APPA; S100A12; AGER; S100B
Amyloid formation
SAA1; HIST3H2BB; NAT8B; CST3; CALCA; RHBDL1; TGFBI; ODAM; TTR; CEACAM21
Binding and Uptake of Ligands by Scavenger Receptors
AMBP; COL1A1; HPX; APOA1B; SPARC; HYOU1; Alb; SCGB3A2; IGLC2; IGKC
Class A/1 (Rhodopsin-like receptors)
CCR6; QRFP; INSL3; QRFPR; SSTR4; GPR132B; GPR4; FPR-RS6; LPAR2A; PPY
Cytosolic sensors of pathogen-associated DNA
DHX9; APPA; S100A12; S100B; ALCAMB; NLRP4C; AGER; TREX1; SAA1; LRRFIP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
APPA; S100B; AGER; SAA1; ALCAMB; CHST13; S100A12; APPB; DHX9
Folate Metabolism
SAA1; SAA2; SAA2-SAA4; AHCY; SAA4; ABCA1

Protein Function

SAA1 has several biochemical functions, for example, G-protein coupled receptor binding, chemoattractant activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAA1 itself. We selected most functions SAA1 had, and list some proteins which have the same functions with SAA1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor binding
Related Protein USP33; CORT; POMC; UCN2; GNAI2B; FYN; RSPO2; HSPA1A; PROK2; GNAT2
Function chemoattractant activity
Related Protein FIGF; HMGB1; FGF10; VEGFA; BMP4; CXCL12B; NTF3; CXCL12A; CCL15; CCL3
Function heparin binding
Related Protein CYR61L1; OVALX; WISP1; BMP7; PF4V1; CYR61; KAL1; NDNF; MPO; F11

Interacting Protein

SAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAA1.
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SAA1 Related Articles

Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).
Matsui, S; Yamane, T; et al. Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 77:2151-2153(2013).