thpo
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  • Official Full Name
  • thrombopoietin
  • Background
  • Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5 UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
  • Synonyms
  • THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand;
Cat.#:Thpo-895MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Thpo Protein
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Cat.#:Thpo-891RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thpo Protein
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Cat.#:THPO-4327BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine THPO Protein
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Cat.#:THPO-1533HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:Thpo-1531MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thrombopoietin
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Cat.#:THPO-269HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-175HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-176HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-216HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human THPO Protein, His-tagged
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Cat.#:THPO-26HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-27HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-29520THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THPO
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Cat.#:THPO-573HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THPO protein, His & GST-tagged
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Cat.#:THPO-80HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human THPO, His-tagged
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Cat.#:THPO-81HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human THPO, Fc-tagged
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Cat.#:THPO-82HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Thrombopoietin
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Cat.#:THPO-861HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human THPO, His tagged
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Cat.#:THPO-98HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Thrombopoietin, His-tagged
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Cat.#:THPO-99HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human THPO protein, His-tagged
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Cat.#:Thpo-177MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Thrombopoietin
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Cat.#:Thpo-1782MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Thrombopoietin, Fc Chimera
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Cat.#:Thpo-97MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Thpo, His tagged
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Cat.#:Thpo-575RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thpo protein, His & T7-tagged
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Cat.#:THPO-6057RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat THPO Protein
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Cat.#:THPO-1163CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus THPO Protein, His-tagged
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Cat.#:THPO-1175CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken THPO
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Cat.#:THPO-7258ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish THPO
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Cat.#:THPO-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human THPO cell lysate
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Cat.#:THPO-2832HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human THPO cell lysate
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Cat.#:THPO-2831MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse THPO cell lysate
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Cat.#:THPO-2273CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus THPO cell lysate
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Cat.#:THPO-13HTag:
Source (Host):Species:Human
Product nameRecombinant Human Thrombopoietin Reference standard
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Cat.#:THPO-P02HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THPO, Fc-tagged therapeutic protein
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Involved Pathway

THPO involved in several pathways and played different roles in them. We selected most pathways THPO participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with THPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL7R; XCL2; Kitl; CCR7; IL12BA; PLEKHO2; CRFB4; CCR6; Cxcl15; TNFRSF4
Jak-STAT signaling pathway
IL12RB1; PRLRA; PTPN2B; PIAS4A; SOCS5; IL24; IFNA3; PTPN11; EP300; LEPB
Hematopoietic cell lineage
CD22; CD37; ITGA6; CD24; CD9; MME; ITGB3; IL2RA; ITGAM; IL5RA

Protein Function

THPO has several biochemical functions, for example, cytokine activity, growth factor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THPO itself. We selected most functions THPO had, and list some proteins which have the same functions with THPO. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IFNA8; CSF1; IL31; LFT2; Flt3l; GRN; IL37; TNFSF13; IFNA21; IL12BA
Function growth factor activity
Related Protein IGF2; VHL; IL3; BTC; IGF2A; MSTNB; FGF6A; GDF7; AMH; PDGFB
Function hormone activity
Related Protein CGA; NMB; PTHLH; CSH2; SMTLB; PRL3B1; SST2; LEPA; CSH1; CRHB

Interacting Protein

THPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THPO here. Most of them are supplied by our site. Hope this information will be useful for your research of THPO.
EP300; APH1A; NUMBL

THPO Related Articles

Kuter, DJ; et al. Milestones in understanding platelet production: a historical overview. BRITISH JOURNAL OF HAEMATOLOGY 165:248-258(2014).
Arai, F; Yoshihara, H; et al. Niche Regulation of Hematopoietic Stem Cells in the Endosteum The Role of Thrombopoietin/Mp1 Signaling in the Maintenance of Quiescent Hematopoietic Stem Cells. HEMATOPOIETIC STEM CELLS VII 1176:36-46(2009).