Human HAT1 Knockdown Cell Lysate

• Cat.No.: HAT1-194HKCL
• Product Overview: WB-validated HAT1 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 50 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg HAT1 KD HeLa cell lysate
• Protein Families: Druggable Genome
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: HAT1 histone acetyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: HAT1
• Synonyms: HAT1; histone acetyltransferase 1; histone acetyltransferase type B catalytic subunit; KAT1
• Gene ID: 8520
• mRNA Refseq: NM_003642
• Protein Refseq: NP_003633
• MIM: 603053
• UniProt ID: O14929