cd86
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  • Official Full Name
  • Cluster of Differentiation 86
  • Background
  • Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
  • Synonyms
  • Cluster of Differentiation 86; CD86; B7-2; B7.2; B70; CD28LG2; LAB72; MGC34413; T-lymphocyte activation antigen CD86; BU63; FUN-1; B7-2 antigen; OTTHUMP00000215511; OTTHUMP00000215512; OTTHUMP00000215513; OTTHUMP00000215514; OTTHUMP00000215515; CD28 antigen ligand 2; activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
Cat.#:CD86-1095HTag:HlgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein (Met1-His239), HlgG1 Fc-tagged
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Cat.#:CD86-322MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD86 Protein, Fc-tagged
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Cat.#:CD86-422HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein (Met1-His239), His-Fc-tagged, Biotinylated
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Cat.#:CD86-799MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD86 Protein (Met1-Glu245), His-tagged, Biotinylated
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Cat.#:CD86-0873HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD86 Protein, His-Flag-StrepII-Tagged
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Cat.#:CD86-0875HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD86 Protein, GST-Tagged
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Cat.#:CD86-019HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CD86 Protein, Fc-tagged
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Cat.#:CD86-10981HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD86, GST-tagged
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Cat.#:CD86-111HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, His-tagged
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Cat.#:CD86-112HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, DDK/His-tagged
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Cat.#:CD86-132HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD86, Fc-tagged
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Cat.#:CD86-133HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, Fc-tagged
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Cat.#:CD86-204HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CD86, Fc Chimera
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Cat.#:CD86-2228HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86, His tagged
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Cat.#:CD86-2229HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, His-tagged
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Cat.#:CD86-27891THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD86
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Cat.#:CD86-355HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD86, MIgG2a Fc-tagged
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Cat.#:CD86-356HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD86, HIgG1 Fc-tagged
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Cat.#:CD86-55HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86, Fc-His tagged
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Cat.#:CD86-575HTag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD86 Protein, Fc Chimera
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Cat.#:CD86-581HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, His & Avi-tagged, Biotinylated
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Cat.#:CD86-583HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD86, His-tagged, Biotinylated
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Cat.#:CD86-584HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD86, Fc-tagged, Biotinylated
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Cat.#:CD86-585HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:CD86-7780HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD86 protein, His & T7-tagged
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Cat.#:Cd86-1706MTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CD86 Antigen
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Cat.#:Cd86-2281MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd86, His tagged
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Cat.#:Cd86-2282MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd86, Fc-His tagged
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Cat.#:CD86-365MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CD86, MIgG2a Fc-tagged
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Cat.#:Cd86-7781MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd86 protein, His & T7-tagged
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Cat.#:Cd86-4087RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd86, His tagged
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Cat.#:Cd86-960RTag:Fc
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Cd86 Protein, Fc Chimera
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Cat.#:CD86-138CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD86, Fc tagged
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Cat.#:CD86-139CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD86, His tagged
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Cat.#:CD86-171CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD86, His-tagged
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Cat.#:CD86-172CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD86 Protein, His-tagged
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Cat.#:CD86-370CTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD86 protein, Fc-tagged
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Cat.#:CD86-752RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD86 Protein, His-tagged
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Cat.#:CD86-3308CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD86
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Cat.#:CD86-2619HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD86 cell lysate
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Cat.#:CD86-2598MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD86 cell lysate
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Cat.#:CD86-1971RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD86 cell lysate
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Cat.#:CD86-1013CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD86 cell lysate
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Involved Pathway

CD86 involved in several pathways and played different roles in them. We selected most pathways CD86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
BMA1; HLA-E; SPN; NRXN2A; F11R.1; OCLN; ESAM; ICOS; CD226; CTLA4
Toll-like receptor signaling pathway
TAB2; NFKBIAB; IFNA21; TLR4BA; IFNA8; IFNPHI3; MAP2K4B; IRF7; IFNA3; TNF
Intestinal i
H2-AB1; CXCL12A; MHC2DEB; ICOS; CCR10; HLA-DOA; CD40; CXCL12; CCL27B; HLA-DRB4
ne network for IgA production
HLA-DOA; CXCR4B; CCR9A; CXCR4A; IL15RA; TNFRSF17; TGFB1; HLA-DQB1; MHC2DCB; CD80
Type I diabetes mellitus
HLA-DQA2; HLA-DOB; H2-Q10; GZMB; HLA-DQB1; ICA1; HLA-C; FAS; PRF1; HLA-DRA
Transcriptional misregulation in cancer
MEN1; ETV7; HHEX; WT1; ELANE; DDX5; ETV1; SP1; CD86; CEBPE
Autoi
CD86; HLA-DQA1; H2-AB1; HLA-DPB1; IL5; HLA-DRB1; Fasl; IFNA7; HLA-E; IFNA6
ne thyroid disease
HLA-DMB; H2-AA; IFNA21; IL5; IFNA5; HLA-DRA; HLA-DQA1; FAS; IFNA8; CD28
Systemic lupus erythematosus
C1QA; HIST1H2BP; H2AFB3; IFNG; HIST1H2BJ; GRIN2A; HIST1H4H; FCGR3; HIST2H3C1; H2AFJ
Rheumatoid arthritis
TNF; HLA-DRA; IL-8; ATP6V1D; IL17A; TGFB1; ITGB2L; VEGFA; CTLA4; FOS
Allograft rejection
CD40LG; H2-AA; IL4; Fasl; HLA-E; HLA-DMB; FASLG; HLA-DRB4; HLA-B; HLA-DRB1
Graft-versus-host disease
HLA-DQB1; HLA-DMB; HLA-DOB; KIR2DL1; CD80; HLA-DPA1; HLA-DRB1; KIR3DL2; HLA-DQA1; IFNG
Viral myocarditis
H2-Q10; ITGB2L; CD28; HLA-DRB1; CD86; CD40LG; CCND1; ACTB; CASP8; HLA-DRB5

Protein Function

CD86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD86 itself. We selected most functions CD86 had, and list some proteins which have the same functions with CD86. You can find most of the proteins on our site.
Function
Related Protein
Function coreceptor activity
Related Protein CD4; PVRL1; HFE2; RGMD; CXCR7B; CD8A; PVRL2; RAMP2; CXCR6; CD28
Function protein binding
Related Protein GET4; SHANK3; CDYL2; HAUS1; PTGFRN; NDUFAF1; ZC3H8; SRSF5; LOC149950; LIN7A
Function receptor activity
Related Protein EXTL3; LILRA2; ITGB3B; MED4; VMN1R49; P2RY1; NPC1; NCR3; GPA33; UBXN6
Function receptor binding
Related Protein MYO1C; CD160; LAMA3; CD200; Ifnl2; Artn; GIPC1; DIAPH1; CCL15; UTS2
Function virus receptor activity
Related Protein MRC1; EFNB2; ITGA2; IDE; GPR172B; MOG; CXCR4; TNFRSF14; HSPA1B; CLEC5A

Interacting Protein

CD86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD86 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD86.
CTLA4; CD80; ECE2; PARP1

CD86 Related Articles

Huizinga, TWJ; et al. Personalized medicine in rheumatoid arthritis: is the glass half full or half empty?. JOURNAL OF INTERNAL MEDICINE 277:178-187(2015).
Wang, L; Sun, XG; et al. Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38(+) Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis. DIGESTIVE DISEASES AND SCIENCES 60:405-413(2015).

CD86 Related Gene Family

Immunoglobulins